Tac-positive, HTLV-negative, T helper phenotype chronic lymphocytic leukemia cells. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Tac-positive, HTLV-negative, T helper phenotype chronic lymphocytic leukemia cells.

Blood. 1985 Jun;65(6):1531-7. Unique Identifier : AIDSLINE MED/85200313
Pandolfi F; De Rossi G; Ranucci A; Bonomo G; Pasqualetti D; Napolitano M; Manzari V

Abstract: In this report we describe an Italian patient with chronic T cell leukemia whose proliferating cells were mature T lymphocytes with a helper phenotype (T helper phenotype chronic lymphocytic leukemia, or Thp-CLL). Unlike other reported cases of Thp-CLL, fresh leukemic cells from this patient were positive with the anti-Tac monoclonal antibody, which recognizes the receptor for interleukin-2 (IL-2). Thus, the phenotype of these cells was similar to that expressed by Japanese patients with adult T cell leukemia (ATL) (OKT3+, OKT4+, OKT8-, Tac+). However, the Italian patient had Thp-CLL, not ATL, since his cells, unlike ATL cells, lacked human T cell leukemia virus (HTLV-I)-related DNA sequences. The Tac receptor, which appears to be modulated in vitro by the anti-Tac antibody, was biologically inactive, since the patient's cells did not respond in vitro to IL-2. In addition, they also failed to demonstrate in vitro functional activities. The clinical course was aggressive, as usual, for both Thp-CLL and ATL. Taking advantage of the description of this case, some similarities and differences between Thp-CLL and ATL are discussed, focusing on the importance of screening of HTLV-I in the differential diagnosis.
Keywords: Aged Antigens, Surface/*ANALYSIS Case Report DNA, Viral/ANALYSIS Human *HTLV-BLV Viruses/GENETICS Interleukin-2/BIOSYNTHESIS Leukemia, Lymphocytic/*IMMUNOLOGY/MICROBIOLOGY Lymphocyte Transformation Male Phenotype Phytohemagglutinins/PHARMACOLOGY Support, Non-U.S. Gov't T-Lymphocytes, Helper-Inducer/*IMMUNOLOGY JOURNAL ARTICLE

KWDagedantigens,surface/KWDanalysiscasereportdna,viral/analysishumanKWDhtlv-blvviruses/geneticsinterleukin-2/biosynthesisleukemia,lymphocytic/KWDimmunology/microbiologylymphocytetransformationmalephenotypephytohemagglutinins/pharmacologysupport,non-uKWDsKWDgov'tt-lymphocytes,helper-inducer/KWDimmunologyjournalarticle
850930
M8590073

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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