AIDS. The Epidemic of Kaposi's Sarcoma and Opportunistic Infections. Friedman-Kien AE, Laubenstein LJ, eds. New York, Masson, p. 279-86, 1984.. Unique Identifier : AIDSLINE ICDB/85610704
Drotman DP; Curran JW; Centers for Disease Control, Atlanta, GA 30333
For the purpose of epidemiologic studies, only patients (pts) with biopsy-proven Kaposi s sarcoma (KS) or biopsy-proven life-threatening opportunistic infection are defined by the Center for Disease Control (CDC) as having the Acquired Immune Deficiency Syndrome (AIDS). This excludes many pts who fall within the spect
Cancer Chemotherapy/6. The EORTC Cancer Chemotherapy Annual. Pinedo HM, Chabner BA, eds. New York, Elsevier Science Publishers, p. 272-84, 1984.. Unique Identifier : AIDSLINE ICDB/85611196
Muggia FM; Div. of Oncology, Dept. of Medicine, N.Y.U. Medical Center, 530; First Ave., New York, NY 10016
An update of the problem of AIDS in relation to antineoplastic chemotherapy covers the following subjects: delineation of AIDS and related syndromes, immunologic findings and pathogenesis, differential diagnosis of specific clinical presentations, therapy of Kaposi s sarcoma (KS), and therapy of other AIDS-related neo
A variety of viruses as etiologic agents in naturally occurring tumors are discussed under the following headings: feline retroviruses; bovine leukemia virus: a new mode of leukemogenesis; simian acquired immunodeficiency syndrome; the natural history of bovine papillomavirus infections; Marek s disease virus in the c
Hardy WD Jr; Lab. of Veterinary Oncology, Memorial Sloan-Kettering Cancer; Center, Sloan-Kettering Div., Graduate Sch. of Medical Sciences,; Cornell Univ., 1275 York Ave., New York, NY 10021
Feline retroviruses occur commonly in their natural species, the pet cat. It has been estimated that there are 40 million cats in the United States , and approx 2% or approx 1 million are infected with feline leukemia virus (FeLV). More pet cats die from FeLV infections than from any ot
Gardner MB; Marx PA; Dept. of Pathology, Sch. of Medicine, Univ. of California, Davis,; CA 95616
The main features of simian acquired immunodeficiency syndrome (SAIDS) are reviewed under the following headings: clinical features, immunologic features, pathology, epidemiology, and virology (initial transmission studies, isolation of type D retroviruses, characterization of virus isolates). The monkey model is comp
Hunsmann G; Hinuma Y; German Primate Center, D-3400 Gottingen, Federal Republic of; Germany
A historical overview of human adult T-cell leukemia virus (ATLV) and its association with disease is presented. ATLV and human T-cell leukemia virus (HTLV) belong to a novel group of retroviruses, tentatively named primate lymphotropic retroviruses. In certain geographic regions, primates, including humans, are often
Henle W; Henle G; Joseph Stokes, Jr., Res. Inst., The Children's Hosp. of; Philadelphia, Philadelphia, PA 19104
The available evidence for an association of Epstein-Barr virus (EBV) with various human malignancies is discussed. Methods used to link EBV with malignancies include demonstration of viral antigens and nucleic acids in tumors and EBV-specific serology. EBV-associated lymphomas include Burkitt s lymphoma (BL) and B-ce
Ziegler JL; Levy JA; Veterans Admin. Medical Center, San Francisco, CA 94121
The acquired immunodeficiency syndrome (AIDS) became clinically apparent as an epidemic in the United States in 1981. AIDS outbreak, starting with homosexual men, but spreading to involve many diverse risk groups, has caught the attention of clinicians, basic scientists, social scienti
Ebbesen P; Olsson L; Vestergaard BF; Ting R; Haahr S
Fibroblast cultures established from the skin of 16 untreated stage 1 and stage 2 Hodgkin s patients (HD) and 60 healthy controls were studied in their 3rd, 4th and 5th in vitro passage. HD cultures were similar to control cultures with respect to transformation with Simian sarcoma virus (SSV) and SV40 and with respec
Trans Am Ophthalmol Soc. 1984;82:447-91. Unique Identifier : AIDSLINE MED/85220174
Friedman AH
AIDS is a reliably diagnosed disease that is indicative of an underlying cellular immunodeficiency with no other cause for the disorder. To date over 2000 cases have been reported in North America and Europe and the number is rising. Patients fulfilling the definition for AIDS have included male homosexuals, IV drug a
The Vancouver Lymphadenopathy-AIDS (acquired immune deficiency syndrome) Study is an ongoing prospective study of over 700 homosexual men attending six primary care practices in central Vancouver. A case-control study of risk factors for persistent generalized lymphadenopathy in homosexual men was conducted in five of
Rene E; Marche C; Regnier B; Saimot AG; Vittecoq B; Matheron S; Le Port C; Bricaire F; Bure A; Brun-Vezinet C; et al
We studied the gastrointestinal manifestations in 26 cases of AIDS. The patients belonged to two different epidemiological groups: the first group included thirteen french homosexual men, the second group included 6 Haitians, 6 Africans and a Pakistanian, none of them admit homosexual activity. The clinical manifestat
A 33-year-old male homosexual AIDS patient was initially admitted to a psychiatric hospital for treatment of a manic episode. Over a 2-month hospitalization, the patient developed progressively severe memory and cognitive impairments which were documented by neuropsychologic testing and were consistent with abnormal E
Two intravenous amphetamine abusers had fatal, rapidly progressive cerebral mucormycosis with abscess formation in the presence of absolute lymphopenia. Postmortem examination confirmed the primary nature of the fungal cerebritis, documented by postmortem culture and histology. The clinical and pathologic features of
Two homosexual men with Kaposi s sarcoma and acquired immune deficiency received radiation therapy to the oral mucosa while treatment with recombinant leukocyte A interferon was being given systemically at a dose of 36 million units. Symptoms of radiation mucositis developed after the administration of 900 rad in the
Am J Hematol. 1985 Jun;19(2):145-50. Unique Identifier : AIDSLINE MED/85222365
Toy PT; Reid ME; Burns M
This study determined the prevalence and clinical significance of a positive direct antiglobulin test (DAT) observed in pretransfusion tests on red cells from patients with acquired immunodeficiency syndrome (AIDS). Transfusion service records showed that prevalence of a positive DAT on red cells was 18% (10/55) in AI
Lymphocytic interstitial pneumonitis (LIP) is characterized by interstitial accumulation of mature lymphocytes, plasma cells, and reticuloendothelial cells and is often an unremitting process unresponsive to immunosuppressive therapy. The patient described in this report had severe candidal esophagitis and immunologic
Pervez NK; Kleinerman J; Kattan M; Freed JA; Harris MB; Rosen MJ; Schwartz IS
A 15-yr-old male hemophiliac developed the acquired immune deficiency syndrome (AIDS). His terminal illness was characterized by rapidly progressive respiratory failure with intermittent wheezing, nonresponsive to bronchodilator and steroid therapy. Postmortem examination revealed a pseudomembrane covering the mucosa
Between April 1982 and March 1984 7 pathologically confirmed cases of progressive multifocal leukoencephalopathy (PML) were diagnosed at our institution. Only 1 case had been seen in the preceding twenty years. Four patients had acquired immunodeficiency syndrome (AIDS). The others had chronic lymphocytic leukemia, Ho
This study compared student attitudes before and after the change from a four- to a five-year D.M.D. program at the Harvard School of Dental Medicine. Three instruments were used to collect data from eight successive classes, the last four enrolled in the original program (classes of 1979-1982) and the first four enro
Annu Rev Public Health. 1985;6:85-106. Unique Identifier : AIDSLINE MED/85199389
Perine PL; Handsfield HH; Holmes KK; Blount JH
We stand on the threshold of a new era for the STDs. The traditional STDs remain serious public health problems, particularly in the developing world, but they pale by comparison with AIDS. We can expect that the number of most STDs will decrease as the baby boom generation ages. We may also witness a change in sexual
Papadopoulos NM; Lane HC; Costello R; Moutsopoulos HM; Masur H; Gelmann EP; Fauci AS
Analysis of serum samples from patients with the acquired immunodeficiency syndrome (AIDS) was performed by high-resolution zone electrophoresis. A high incidence of monoclonal and oligoclonal immunoglobulins was detected in the sera of 24/27 patients with Kaposi s sarcoma and in 2/15 patients with opportunistic infec
Science. 1985 Jun 7;228(4704):1199-201. Unique Identifier : AIDSLINE MED/85218784
Kanki PJ; McLane MF; King NW Jr; Letvin NL; Hunt RD; Sehgal P; Daniel MD; Desrosiers RC; Essex M
Human T-lymphotropic virus type III (HTLV-III) is thought to play an etiologic role in the development of the acquired immune deficiency syndrome (AIDS). In this study the serologic characterization of a new simian retrovirus that is related to HTLV-III is described. This new virus, here referred to as STLV-III, was i
Science. 1985 Jun 7;228(4704):1211-5. Unique Identifier : AIDSLINE MED/85218789
Rodman TC; Laurence J; Pruslin FH; Chiorazzi N; Winston R
A set of naturally occurring immunoglobulin M (IgM) antibodies that are reactive with a defined subset of proteins in the acrosomal cap region of human sperm has been identified. These antibodies are present in a broad spectrum of human sera from males and females, 1 day to 40 years of age, and are absent or markedly
The purine metabolic enzymes adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) are important in lymphocyte differentiation, and genetic deficiencies of either enzyme have been associated with hereditary immunodeficiency states. Both ADA and PNP activity were measured in null cell-enriched and T cell-
Nearly one-third of all young homosexual men diagnosed as having acquired immune-deficiency syndrome (AIDS) develop a disseminated form of dermal Kaposi s sarcoma (KS). Although the histogenesis of KS cells is unclear, certain evidence suggests that the aberrant cells are of endothelial derivation. We have examined th
Public Health Rep. 1985 May-Jun;100(3):261-9. Unique Identifier : AIDSLINE MED/85217102
Parra WC; Cates W Jr
The problem of sexually transmitted diseases (STDs) in the United States has been growing, in both scope and complexity, at an alarming rate. As evidence of the emergence of these diseases as a primary national concern, the Surgeon General has designated them as 1 of 15 priority areas
Ter Arkh. 1985;57(2):68-71. Unique Identifier : AIDSLINE MED/85219463
Farber NA
The author reviews virus associations on combination (1) of virus hepatitides A and B, (2) virus hepatitides A and non-A, non-B, (3) virus hepatitides B and non-A, non-B, (4) virus hepatitis B during superinfection with a delta-agent; (5) virus hepatitis B and the acquired immunodeficiency syndrome. Describes clinical
Levy N; Boone D; Hechinger M; Levine AM; Meyer P; Louie J; Parker JW
Significant progress has been made in defining the clinical features, immunologic defects, and etiologic agent(s) of the acquired immune deficiency syndrome (AIDS) and its related disorders, but much remains to be learned about the natural history and pathogenesis of these diseases. Most immunologic studies to date ha
Vaith P; Maas D; Feigl D; Hauke G; Lang B; Oepke G; Stierle HE; Bross KJ; Andreesen R; Gross G; et al
We report on a lethal course of an acquired immunodeficiency syndrome (AIDS) in a young female patient. She had spent her vacancies six years before diagnosis in Haiti , where a sexual intercourse with a Haitian man had occurred. Leading clinical symptoms consisted of recurrent Herpe
The CDC estimates that about 200,000 Americans become infected with HBV each year. About 200 die of fulminant hepatitis. Most importantly, 12,000 to 20,000 persons become chronically infected, placing themselves at increased risk of developing chronic sequelae such as cirrhosis and primary hepatocellular carcinoma and
Med Hypotheses. 1985 Mar;16(3):189-206. Unique Identifier : AIDSLINE MED/85213165
McCarty MF
Allogeneic lymphocytes can exert very potent non-specific immunomodulatory effects both in vitro and in vivo. Repeated infusions of allogeneic suppressor or helper populations may find use in the treatment of diseases characterized by impaired suppressor function (such as many autoimmune diseases) or impaired helper f
Histocompatibility antigens represent the biological basis of individuality. They make men different from one another and represent the essence of self which is continuously protected from non self by the immune system. Both fecundation and the evolution of pregnancy are favoured by a marked difference in histocompati
Presse Med. 1985 May 25;14(21):1177-80. Unique Identifier : AIDSLINE MED/85216339
Devars du Mayne JF; Marche C; Penalba C; Vittecoq D; Saimot G; Cerf M
Liver biopsies were systematically performed in 20 patients with evidence of an acquired immunodeficiency syndrome (18 with opportunistic infections, 9 with Kaposi s sarcoma). Hepatitis, related to hepatitis-B virus in 3 cases and to cytomegalovirus in 3 cases, was present in 6 of
Pichler WJ; Emmendorffer A; Peter HH; Deicher HR; Fontana A; de Weck AL
Two T-lymphocyte subsets develop in the thymus which differ in the expression of glycoproteins on their cell surface. About 60% of the circulating T cells express the glycoprotein T4, while about 30% have the glycoprotein T8. T4 and T8 cells can be determined in the peripheral blood or various organs with monoclonal a
Science. 1985 Jun 7;228(4704):1201-4. Unique Identifier : AIDSLINE MED/85218785
Daniel MD; Letvin NL; King NW; Kannagi M; Sehgal PK; Hunt RD; Kanki PJ; Essex M; Desrosiers RC
The isolation of a T-cell tropic retrovirus from three immunodeficient macaques and one macaque with lymphoma is described. The morphology, growth characteristics, and antigenic properties of this virus indicate that it is related to the causative agent of acquired immune deficiency syndrome in humans (HTLV-III or LAV
Kuriyama M; Nomura K; Tara M; Matsubara H; Igata A
We analyzed lipids from leukemic cells of two patients with adult T-cell leukemia and compared them with those from T-cell lymphocytes of normal subjects. The neutral glycosphingolipids and gangliosides which were isolated were characterized by thin-layer chromatography and neuraminidase treatment. Both leukemic cells
The virus-associated hemophagocytic syndrome (VAHS) is a disorder characterized by a benign, generalized histiocytic proliferation, with marked hemophagocytosis associated with systemic viral infections. We have studied the virological and immunopathological events occurring in two children experiencing Epstein-Barr V
Pandolfi F; De Rossi G; Ranucci A; Bonomo G; Pasqualetti D; Napolitano M; Manzari V
In this report we describe an Italian patient with chronic T cell leukemia whose proliferating cells were mature T lymphocytes with a helper phenotype (T helper phenotype chronic lymphocytic leukemia, or Thp-CLL). Unlike other reported cases of Thp-CLL, fresh leukemic cells from this patient were positive with the ant
Recent studies indicate a high prevalence of seropositivity to the lymphadenopathy-associated virus/human T-lymphotropic virus (type III) among individuals with hemophilia exposed to clotting factor concentrates prepared from large donor pools. The peripheral blood lymphocytes of 19 young seropositive patients with in
Can Med Assoc J. 1985 Jun 1;132(11):1261-7. Unique Identifier : AIDSLINE MED/85201280
Wainberg MA; Mills EL
The recent demonstration that the acquired immune deficiency syndrome (AIDS) is caused by a retrovirus that affects humans has given rise to widespread concern about the immunosuppressive properties of viruses in general. A wide variety of viruses have been shown to be able to compromise immune function. Sometimes imm
Hemler ME; Jacobson JG; Brenner MB; Mann D; Strominger JL
The VLA-1 protein complex defines a previously undescribed very late stage of activated T cell differentiation, following either alloantigen or mitogen activation. This protein appears after 2-3 weeks of activation, considerably later than the early T cell activation antigens such as the interleukin 2 (IL 2) receptor,
Int J Cancer. 1985 May 15;35(5):629-35. Unique Identifier : AIDSLINE MED/85206412
Kitamura T; Takano M; Hoshino H; Shimotohno K; Shimoyama M; Miwa M; Takaku F; Sugimura T
The methylation patterns of the gag, pol, env, pX and LTR regions of proviral DNA of human T-cell leukemia/lymphoma virus type I (HTLV) in fresh leukemic cells and established cell lines were examined using HpaII/MspI endonuclease. Peripheral blood lymphocytes (PBL) isolated from patients with adult T-cell leukemia/ly
The in vitro effects of isoprinosine (ISO) on interleukin-2 ( IL-2 ) production, the expression of Tac antigen (IL-2 receptor) on lymphocytes, and the ability of Leu 3(+) cells to absorb interleukin-1 (IL-1) were investigated in 10 patients with acquired immune deficienc
Palker TJ; Scearce RM; Ho W; Copeland TD; Oroszlan S; Popovic M; Haynes BF
Three monoclonal antibodies to human T cell lymphotropic virus type I (HTLVI) p19 internal core protein, designated as alpha HTLV-2, 3, and 4, have been developed. In indirect immunofluorescence (IF) assays, these antibodies reacted with acetone-fixed cytocentrifuge preparations of culture HTLVI-infected peripheral bl
A variant of human T-cell leukemia virus subgroup I (HTLV-I), designated HTLV-Ib, has been isolated from a transformed T-lymphocytic cell line established from a Zairian patient with adult T-cell lymphoma. A recombinant phage clone of the variant provirus, denoted lambda MC-1, hybridizes under high stringency to HTLV-
JAMA. 1985 Jun 7;253(21):3116-8. Unique Identifier : AIDSLINE MED/85211213
Ammann AJ; Kaminsky L; Cowan M; Levy JA
Antibody to acquired immunodeficiency syndrome (AIDS)-associated retroviruses (ARVs) was investigated in 68 pediatric patients with abnormalities of T-cell and/or B-cell immunity. All except seven patients conformed to a specific World Health Organization classification for immunodefic
JAMA. 1985 Jun 21;253(23):3405-8. Unique Identifier : AIDSLINE MED/85211257
Carlson JR; Bryant ML; Hinrichs SH; Yamamoto JK; Levy NB; Yee J; Higgins J; Levine AM; Holland P; Gardner MB; et al
The performance characteristics of the acquired immunodeficiency syndrome (AIDS)-retrovirus serological tests including enzyme-linked immunosorbent assay (ELISA), Western blot, and immunofluorescence assay were defined in a clinical laboratory setting by testing 1,257 serum specimens from low- and high-risk groups for
JAMA. 1985 Jun 21;253(23):3409-15. Unique Identifier : AIDSLINE MED/85211258
Jason J; McDougal JS; Holman RC; Stein SF; Lawrence DN; Nicholson JK; Dixon G; Doxey M; Evatt BL
We studied the human T-lymphotropic retrovirus type III/lymphadenopathy-associated virus (HTLV-III/LAV) antibody status of 234 factor VIII concentrate recipients, 36 factor IX concentrate recipients, 69 long-term recipients of frozen packed red blood cells, and 47 persons not receiving routine transfusion therapy. Fac
JAMA. 1985 Jun 21;253(23):3425-8. Unique Identifier : AIDSLINE MED/85211261
Burkes RL; Gal AA; Stewart ML; Gill PS; Abo W; Levine AM
The most common manifestations of the acquired immunodeficiency syndrome include Pneumocystis carinii pneumonia and/or Kaposi s sarcoma. High-grade B-cell lymphomas have also been reported in homosexual men at risk for the acquired immunodeficiency syndrome. We herein present the case of a homosexual man, who presente
The effect of all-trans-retinoic acid (RA) on cellular transformation and on tumorigenicity of retrovirally transformed cells was investigated. RA treatment of NRK and NIH/3T3 cells transformed by BALB/c murine sarcoma virus (MuSV), Kirsten murine sarcoma virus (K-MuSV), and simian sarcoma virus resulted in a signific
De Vecchis L; Graziani G; Macchi B; Grandori C; Pastore S; Popovic M; Gallo RC; Bonmassar E
Cell-mediated natural cytotoxicity (CMNC) of fresh or long-term cultured lymphocytes collected from HTLV-positive patients or infected in vitro with the virus, was tested against K562 target cells. Severe depression of reactivity was found in fresh lymphocytes of three patients with advanced disease, in 12 in vitro es
In order to investigate the nature of the T cell defect associated with the acquired immune deficiency syndrome (AIDS) we studied the ability of peripheral blood mononuclear cells from 8 patients with Kaposi s sarcoma (KS), 2 with opportunistic infection (OI), 23 with AIDS-related symptoms complex (ARC) without KS or
Med Microbiol Immunol (Berl). 1985;174(1):35-42. Unique Identifier : AIDSLINE MED/85213253
Schneider J; Bayer H; Bienzle U; Hunsmann G
Sera from homosexuals and hemophiliacs in Germany were examined for antibodies to human T-lymphotropic retrovirus type III (HTLV-III) by an enzyme-linked immunosorbent assay (ELISA) against purified virus. ELISA positive sera were used to search by immunoprecipitation for HTLV-III
Lane HC; Depper JM; Greene WC; Whalen G; Waldmann TA; Fauci AS
We studied purified subpopulations of lymphocytes from patients with the acquired immunodeficiency syndrome (AIDS) in order to determine whether intrinsic defects in lymphocyte function, aside from those due to alterations in lymphocyte numbers, were present. Mitogen-stimulated DNA synthesis, production of gamma inter
Pepose JS; Holland GN; Nestor MS; Cochran AJ; Foos RY
A gross, light, and electron microscopic study of the eyes from 35 consecutive autopsy cases of the acquired immune deficiency syndrome revealed cotton-wool spots (71% of cases), retinal hemorrhage in areas without cytomegalovirus infection (40%), cytomegalovirus retinitis (34%) wi
A high level of suspicion by every provider is very important to ensure diagnosis and complete reporting. Such active surveillance will enable effective national monitoring of the occurrence of the disease, the definition of new risk groups and the identification of unusual cases for further study. Physicians and heal
Proc Natl Acad Sci U S A. 1985 May;82(10):3101-5. Unique Identifier : AIDSLINE GENBANK/M10060
Shimotohno K; Takahashi Y; Shimizu N; Gojobori T; Golde DW; Chen IS; Miwa M; Sugimura T
The entire nucleotide sequence of an infectious clone of human T-cell leukemia virus type II provirus was determined. This provirus consists of 8952 nucleotides. In addition to long terminal repeats and gag, pol, env, and X, a protease gene that is responsible for processing the gag precursor protein was found. The pr
Proc Natl Acad Sci U S A. 1985 May;82(10):3481-4. Unique Identifier : AIDSLINE MED/85216525
Sarngadharan MG; Bruch L; Popovic M; Gallo RC
Antigenic cross-reactivity of human T-cell leukemia virus type III (HTLV-III) with HTLV-I and HTLV-II and other retroviruses was measured by using a stringent homologous competition radioimmunoassay for the Gag protein p24 and a less stringent electrophoretic transfer blot assay. In the competition radioimmunoassay on
Antigen- or lectin-stimulated T lymphocytes and human T-cell leukemia virus (HTLV)-infected cell lines secrete lymphokines that can influence the growth and function of a variety of cell types. We recently demonstrated that supernatants from the HTLV-II-infected Mo-T-cell line stimulate the proliferation of rat brain
Balthazar EJ; Megibow AJ; Fazzini E; Opulencia JF; Engel I
Radiographic findings in 11 proved cases of cytomegalovirus ( CMV ) colitis were reviewed and correlated with colonoscopic and pathologic findings. Patients were chronically ill homosexual men with multiple systemic opportunist
Schweiz Med Wochenschr. 1985 May 11;115(19):665-71. Unique Identifier : AIDSLINE MED/85218688
Vogt M; Luthy R; Siegenthaler W
At the end of December 1984, 8246 AIDS cases had been reported in the United States , and 762 cases in Europe. The main risk groups are homosexual and bisexual men (73%), heterosexual i.v. drug addicts (17%) and Haitians (4%). AIDS is diagnosed in patients meeting the clinical criteria
Science. 1985 Jun 7;228(4704):1215-7. Unique Identifier : AIDSLINE MED/85218790
Kronke M; Leonard WJ; Depper JM; Greene WC
Infection of human T cells by human T-lymphotropic virus, type I (HTLV-I), a retrovirus, is uniformly associated with the constitutive expression of large numbers of cellular receptors for interleukin-2 ( IL-2 ). Comparison with normal T cells shows that neither IL-2 rec
S Afr Med J. 1985 Jun 15;67(24):961-2. Unique Identifier : AIDSLINE MED/85219122
Lyons SF; Schoub BD; McGillivray GM; Sher R
A preliminary survey has demonstrated that antibodies directed against human T-cell leukaemia virus type III (HTLV-III), the virus implicated as the agent causing the acquired immunodeficiency syndrome, are not present in the low-risk population groups studied. The survey, in which an indirect immunofluorescence assay
Acta Med Okayama. 1985 Apr;39(2):155-9. Unique Identifier : AIDSLINE MED/85221638
Akagi T; Ohtsuki Y; Shiraishi Y; Miyoshi I
Co-cultivation of human thymus and spleen lymphocytes, which were obtained from 26-week and 27-week fetuses, with a lethally-irradiated human cord T-cell line harboring human T-cell leukemia virus type I (HTLV-I) resulted in the establishment of T-cell lines positive for adult T-cell leukemia-associated antigens and p
The radiographic features of cytomegalovirus involvement of the upper gastrointestinal tract in four homosexual men with acquired immunodeficiency syndrome (AIDS) are described. Esophageal involvement (three cases) was demonstrated as a localized ulceration or as a more diffuse eso
Am J Gastroenterol. 1985 Jun;80(6):434-7. Unique Identifier : AIDSLINE MED/85222344
Freedman PG; Weiner BC; Balthazar EJ
Symptomatic cytomegalovirus involvement of the gastrointestinal tract has become increasingly recognized in patients with acquired immunodeficiency syndrome. This may take varying forms, often mimicking more well known entities. This is a report of a male intravenous drug abuser wi
Am J Gastroenterol. 1985 Jun;80(6):445-7. Unique Identifier : AIDSLINE MED/85222347
Levinson W; Bennetts RW
A patient with acquired immunodeficiency syndrome and cytomegalovirus colitis is described. The colitis is more chronic and less severe than earlier descriptions. This case presents different and more varied endoscopic findings than previously reported.
Three patients had a typical clinical, functional, and histologic pattern of lymphoid interstitial pneumonitis (LIP). All 3 also had a marked follicular and interfollicular hyperplasia of peripheral lymph nodes. A benign lymphocytic infiltration was seen in the kidneys in 2 patients, in the liver of 1 of these, and in
Ann Intern Med. 1985 Jul;103(1):37-42. Unique Identifier : AIDSLINE MED/85223515
Nicholson JK; McDougal JS; Jaffe HW; Spira TJ; Kennedy MS; Jones BM; Darrow WW; Morgan M; Hubbard M
Immunologic and serologic studies were done in 120 homosexual men who reportedly had no symptoms related to the acquired immunodeficiency syndrome. Forty-nine men (41%) had antibody to the retrovirus human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV), and 37 (31%) had an abnormal T-cel
Ann Intern Med. 1985 Jul;103(1):61-3. Unique Identifier : AIDSLINE MED/85223522
Drew WL; Mills J; Levy J; Dylewski J; Casavant C; Ammann AJ; Brodie H; Merigan T
T-helper:T-suppressor cell ratios of 1 or less were found in 2 of 42 homosexual men without antibodies to cytomegalovirus but in 33 of 67 homosexual men with antibodies (p less than 0.001). Of 34 men without antibody who were followed prospectively, 12 became seropositive for cytom
We are reporting the cases of four children with a diagnosis of acquired immune deficiency syndrome (AIDS) who demonstrated a progressive encephalopathy manifested by loss of motor milestones or intellectual abilities, and weakness with pyramidal tract signs. Two patients were ataxic. One child was cortically blind an
Koike T; Kagami M; Takabayashi K; Maruyama N; Tomioka H; Yoshida S
It has been anticipated that type C oncornaviruses, which participate in the pathogenesis of murine systemic lupus erythematosus (SLE), would be found to have a role in the development of SLE in humans. In studies of tissues from SLE patients, type C-related proteins have been identified. Using information obtained on
The prevalence of antibody to HTLV-III has increased from 3.7% (4/107) amongst unselected British homosexual men attending a London sexually transmitted disease (STD) clinic during one week in March, 1982, to 21% (26/124) in those attending during one week in July, 1984. Seropositive men had a significantly higher pre
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