The acquired immunodeficiency syndrome in a cohort of homosexual men. A six-year follow-up study. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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The acquired immunodeficiency syndrome in a cohort of homosexual men. A six-year follow-up study.

Ann Intern Med. 1985 Aug;103(2):210-4. Unique Identifier : AIDSLINE MED/85249669
Jaffe HW; Darrow WW; Echenberg DF; O'Malley PM; Getchell JP; Kalyanaraman VS; Byers RH; Drennan DP; Braff EH; Curran JW; et al

Abstract: A cohort of 6875 homosexual men, initially seen at the San Francisco City Clinic between 1978 and 1980, were studied to determine the incidence and prevalence of the acquired immunodeficiency syndrome, related conditions, and infection with the human T-lymphotropic virus, type III/lymphadenopathy-associated virus (HTLV-III/LAV). By December 1984, 2.4% of the men had the syndrome; mortality attributable to the syndrome in 1984 was 600/100 000. For each man with the syndrome in a representative sample of 474 cohort members seen in 1984, 7.5 men had generalized lymphadenopathy, 1.1 had other prodromal findings, and 0.8 had hematologic abnormalities. Prevalence of serum antibodies to HTLV-III/LAV, measured by an enzyme-linked immunosorbent assay, increased from 4.5% in 1978 to 67.4% in 1984. Of 31 persons who were seropositive and without the syndrome between 1978 and 1980, 2 developed the syndrome and 8 developed related conditions during a median follow-up of 61 months. Over a 6-year period, two thirds of cohort members were infected with HTLV-III/LAV and almost one third developed related conditions.
Keywords: Acquired Immunodeficiency Syndrome/*EPIDEMIOLOGY/MICROBIOLOGY/ MORTALITY Adult Antibodies, Viral/ANALYSIS California Enzyme-Linked Immunosorbent Assay Epidemiologic Methods Follow-Up Studies *Homosexuality Human HTLV-BLV Viruses/IMMUNOLOGY Lymphatic Diseases/EPIDEMIOLOGY Male Serodiagnosis JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDepidemiology/microbiology/mortalityadultantibodies,viral/analysiscaliforniaenzyme-linkedimmunosorbentassayepidemiologicmethodsfollow-upstudiesKWDhomosexualityhumanhtlv-blvviruses/immunologylymphaticdiseases/epidemiologymaleserodiagnosisjournalarticle
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Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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