Subcutaneous fibromatosis associated with an acquired immune deficiency syndrome in pig-tailed macaques. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Subcutaneous fibromatosis associated with an acquired immune deficiency syndrome in pig-tailed macaques.

Am J Pathol. 1985 Jul;120(1):30-7. Unique Identifier : AIDSLINE MED/85248839
Tsai CC; Warner TF; Uno H; Giddens WE Jr; Ochs HD

Abstract: A spontaneous multifocal subcutaneous fibromatosis is described in 6 pig-tailed macaques (Macaca nemestrina) with simian acquired immune deficiency syndrome (simian AIDS). The lesions consisted of a proliferation of vascular fibrous tissue that was infiltrated by lymphocytes and plasma cells. One animal also had retroperitoneal fibromatosis, which has also been found in this colony of pig-tailed macaques. Progressive weight loss, diarrhea, lymphadenopathy, and neutropenia were seen. Peripheral lymph nodes were hyperplastic, and there was splenomegaly. Aggregates of lymphocytes were present in the bone marrow, kidneys, liver, and lungs. Type D retrovirus particles were found in three nodules by electron microscopy; intracytoplasmic type A and budding particles were identified in fibroblasts. In a setting of acquired immunodeficiency, these subcutaneous tumors in pig-tailed macaques present a striking analogy to Kaposi's sarcoma in human AIDS.
Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS/PATHOLOGY/ *VETERINARY Animal Female Fibroma/IMMUNOLOGY/PATHOLOGY/ULTRASTRUCTURE/*VETERINARY Macaca/*IMMUNOLOGY Macaca nemestrina/*IMMUNOLOGY Male Retroperitoneal Neoplasms/PATHOLOGY/VETERINARY Sarcoma, Kaposi's/PATHOLOGY Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/complications/pathology/KWDveterinaryanimalfemalefibroma/immunology/pathology/ultrastructure/KWDveterinarymacaca/KWDimmunologymacacanemestrina/KWDimmunologymaleretroperitonealneoplasms/pathology/veterinarysarcoma,kaposi's/pathologysupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
851030
M85A0140

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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