Abnormal lymphocyte response to exogenous interleukin-2 in homosexuals with acquired immune deficiency syndrome (AIDS) and AIDS related complex (ARC). NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Abnormal lymphocyte response to exogenous interleukin-2 in homosexuals with acquired immune deficiency syndrome (AIDS) and AIDS related complex (ARC).

Clin Exp Immunol. 1985 Apr;60(1):25-30. Unique Identifier : AIDSLINE MED/85228975
Murray JL; Hersh EM; Reuben JM; Munn CG; Mansell PW

Abstract: Interleukin-2 (IL-2) production as well as the response of lymphocytes to exogenous IL-2 was measured in asymptomatic homosexuals, patients with acquired immune deficiency syndrome (AIDS), and homosexuals with prodromal symptoms. IL-2 production following lectin stimulation was not significantly different in homosexuals compared to age matched heterosexual controls. In contrast, the response of lymphocytes to exogenous IL-2 was significantly decreased in AIDS and homosexuals with prodromal symptoms compared to asymptomatic homosexuals and heterosexual controls. These data, combined with the data of others, suggest that an underlying immune defect in AIDS is abnormal IL-2 receptor expression and resultant poor IL-2 response.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Female *Homosexuality Human Interleukin-2/ADMINISTRATION & DOSAGE/*BIOSYNTHESIS Kinetics Lymphocyte Transformation Male Receptors, Immunologic/IMMUNOLOGY Support, U.S. Gov't, P.H.S. T-Lymphocytes/IMMUNOLOGY Time Factors JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDimmunologyfemaleKWDhomosexualityhumaninterleukin-2/administration&dosage/KWDbiosynthesiskineticslymphocytetransformationmalereceptors,immunologic/immunologysupport,uKWDsKWDgov't,pKWDhKWDsKWDt-lymphocytes/immunologytimefactorsjournalarticle
851030
M85A0105

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