Comparative analysis of the human and feline c-sis proto-oncogenes. Identification of 5' human c-sis coding sequences that are not homologous to the transforming gene of simian sarcoma virus. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Comparative analysis of the human and feline c-sis proto-oncogenes. Identification of 5' human c-sis coding sequences that are not homologous to the transforming gene of simian sarcoma virus.

Biochim Biophys Acta. 1985 Jun 24;825(2):140-7. Unique Identifier : AIDSLINE MED/85226456
van den Ouweland AM; Breuer ML; Steenbergh PH; Schalken JA; Bloemers HP; Van de Ven WJ

Abstract: Feline and human genetic sequences, homologous to the v-sis gene of simian sarcoma virus, have been isolated from cosmid gene libraries and characterized by restriction endonuclease analysis. Comparison of the two loci revealed their related structural organization. In both loci, similar unique genetic sequences were found upstream of the v-sis homologous region and these hybridized to a 4.2 kbp c-sis transcript in human lung tumor cells. These data establish and map as yet unidentified coding sequences at the 5' part of the c-sis proto-oncogene of both species.
Keywords: Animal Base Sequence Cats Cloning, Molecular Comparative Study DNA Restriction Enzymes/METABOLISM Electrophoresis, Agar Gel Human Nucleic Acid Hybridization *Oncogenes Peptides/*GENETICS Retroviridae/*GENETICS Sarcoma Viruses, Simian/*GENETICS Support, Non-U.S. Gov't Transcription, Genetic JOURNAL ARTICLE

KWDanimalbasesequencecatscloning,molecularcomparativestudydnarestrictionenzymes/metabolismelectrophoresis,agargelhumannucleicacidhybridizationKWDoncogenespeptides/KWDgeneticsretroviridae/KWDgeneticssarcomaviruses,simian/KWDgeneticssupport,non-uKWDsKWDgov'ttranscription,geneticjournalarticle
851030
M85A0091

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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