Molecular and immunologic analysis of a chronic lymphocytic leukemia case with antibodies against human T-cell leukemia virus. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Molecular and immunologic analysis of a chronic lymphocytic leukemia case with antibodies against human T-cell leukemia virus.

Cancer. 1985 Aug 1;56(3):495-9. Unique Identifier : AIDSLINE MED/85227903
Clark JW; Hahn BH; Mann DL; Wong-Staal F; Popovic M; Richardson E; Strong DM; Lofters WS; Blattner WA; Gibbs WN; et al

Abstract: The human T-cell leukemia virus type-I (HTLV-I) is a unique, exogenous, horizontally transmitted retrovirus which is T-cell tropic, and has been associated with a specific type of aggressive leukemia/lymphoma of mature T-cell origin. In a survey of lymphoid malignancies in Jamaica, antibodies to HTLV-I were also found in 6 of 17 patients with chronic lymphocytic leukemia (CLL), raising the possibility of an etiologic relationship. Further studies were undertaken on one of these patients to clarify the nature of the disease and possible virus relationship. Cell surface marker analysis of her peripheral blood cells documented that the majority of circulating lymphocytes were B-cells. DNA-cloned probe analysis with a complete HTLV-I proviral genome of these peripheral malignant B-cells, was negative for integrated virus. A T-cell line was established in culture from her peripheral blood. The presence of HTLV-I in the cultured T-cell line was established by the detection of expressed viral specific gag protein p-19 and proviral DNA. Thus, a B-cell lymphoid malignancy can occur in the presence of HTLV-I infected T-cells, suggesting the possibility of an indirect leukemogenic mechanism.
Keywords: Aged Antibodies, Viral/*ANALYSIS B-Lymphocytes/IMMUNOLOGY Case Report DNA, Viral/IMMUNOLOGY Enzyme-Linked Immunosorbent Assay Female Human HTLV-BLV Viruses/IMMUNOLOGY IgG/ANALYSIS Immunoglobulin Idiotypes/ANALYSIS Jamaica Leukemia, Lymphocytic/*IMMUNOLOGY Retroviridae Infections/*IMMUNOLOGY T-Lymphocytes/IMMUNOLOGY Viral Proteins/IMMUNOLOGY JOURNAL ARTICLE

KWDagedantibodies,viral/KWDanalysisb-lymphocytes/immunologycasereportdna,viral/immunologyenzyme-linkedimmunosorbentassayfemalehumanhtlv-blvviruses/immunologyigg/analysisimmunoglobulinidiotypes/analysisjamaicaleukemia,lymphocytic/KWDimmunologyretroviridaeinfections/KWDimmunologyt-lymphocytes/immunologyviralproteins/immunologyjournalarticle
851030
M85A0082

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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