New York, N.Y. : Network for Continuing Medical Education, 1985 1 videocassette (47 min.) : sd., col. ; 3/4 in. + 1 booklet (NCME telecourse ; no. 458) Unique Identifier : AIDSLINE AV/8500531A
Klein RS
Examines who is at risk and who is not, protective measures, signs and symptoms to look for in patients suspected of having AIDS, and the prognosis for those with this syndrome. Discusses how to perform a physical exam uncovering signs suggesting AIDS and related disorders as well as the ordering and interpretation o
J Bras Med; 47(3):96-105 1984. Unique Identifier : AIDSLINE ICDB/85612906
Correa JC; Goncalves De Carvalho F; Gomes E Jr; De Lima RJ; Clinica do Servico de Clinica Medica do HC, IASERJ
A case of Acquired Immune Deficiency Syndrome (AIDS) is reported. The patient was a 35 year old white Brazilian man who presented in May, 1982 with diarrhea for 1 month and weight loss. History was significant for homosexual relations; for generalized lymphadenopathy 2 years previously, diagnosed and treated as tuberc
Ann Endocrinol (Paris). 1984;45(6):355-68. Unique Identifier : AIDSLINE MED/85250204
Martin-Du-Pan RC
The epithelial cells of the thymus synthesize at least 30 different polypeptides: the thymic hormones. The structure of 4 of them is well known. They are named thymosin alpha 1, thymopoietin, thymulin and thymic humoral factor. Biological functions and secretion regulation of thymic hormones are described as well as t
Toth FD; Szabo B; Vaczi L; Kiss A; Kovacs I; Rak K; Kiss C; Gallo RC
Blood plasma samples from adult patients and children with malignant lymphoproliferative diseases were studied for presence of antibodies to primate type-C viruses by membrane immunofluorescence. Antibodies to baboon endogenous virus could be detected in various types of lymphoid leukaemias and lymphomas. Gibbon ape l
The obstetrician and pediatrician must be alert to the potential development of AIDS in children born to mothers with AIDS/ARC or to healthy mothers who belong to a risk group for AIDS. Serologic studies for HTLV-III should be conducted during pregnancy. In the future it may be possible to identify the AIDS virus or a
Homosexual men with acquired immunodeficiency syndrome and Kaposi s sarcoma (KS) have been studied to define the extent of gastrointestinal KS. In 50 patients examined by both upper endoscopy and flexible fiberoptic sigmoidoscopy, 20 (40%) had visible lesions consistent with KS. Ten patients (20%) had upper and lower
Desportes I; Le Charpentier Y; Galian A; Bernard F; Cochand-Priollet B; Lavergne A; Ravisse P; Modigliani R
A new microsporidium is reported infesting the enterocytes of a Haitian patients with AIDS. The stages observed were diplokaryotic cells, sporogonial plasmodia, unikaryotic sporoblasts, and spores. Neither a sporophorous vesicle (pansporoblastic membrane) nor parasitophorous vacuole were differentiated around the deve
Chamberland ME; Allen JR; Monroe JM; Garcia N; Morgan C; Reiss R; Stephens H; Walker J; Friedman SM
In January 1983, the New York City Department of Health initiated an active surveillance program for acquired immunodeficiency syndrome (AIDS) in 19 hospitals and a modified-active surveillance program in the remaining 69 hospitals. We reviewed hospital laboratory and autopsy records in 12 active surveillance hospital
Carini L; Meregaglia LD; Galli C; Segalini G; Strada M; Jones J; Witte MH; Witte CL
Two adult patients (one in Italy and the other in the USA) are described with similar findings of paraaortic nodal aplasia, asplenism, multiple serous and chylous effusions, and retroperitoneal lymphatic dysplasia. Although the clinical courses are incomplete, this unusual constella
Koppel BS; Wormser GP; Tuchman AJ; Maayan S; Hewlett D Jr; Daras M
Central nervous system involvement occurred in 28 of 121 patients with acquired immune deficiency syndrome (AIDS). The major risk factor in this AIDS population was intravenous drug abuse (64%). A neurologic symptom or disability was the principal reason for hospitalization in 16 cases (57%). Three patients had primar
Acquired immunodeficiency syndrome (AIDS) is a severe disorder of unknown etiology and pathogenesis, predominantly affecting homosexual males and other high-risk groups and characterized by profound alterations in T-lymphocyte function. The authors have examined thymus tissue from 14 patients who died of AIDS and comp
Am J Epidemiol. 1985 Jun;121(6):797-810. Unique Identifier : AIDSLINE MED/85248395
Johnson RE; Lawrence DN; Evatt BL; Bregman DJ; Zyla LD; Curran JW; Aledort LM; Eyster ME; Brownstein AP; Carman CJ
The acquired immunodeficiency syndrome (AIDS) was first recognized among hemophiliacs in 1982. The authors have conducted investigations to determine the onset and incidence of AIDS among hemophiliacs and to determine trends in hemophilia mortality since the introduction of clotting-factor concentrates in the late 196
Am J Pathol. 1985 Jul;120(1):30-7. Unique Identifier : AIDSLINE MED/85248839
Tsai CC; Warner TF; Uno H; Giddens WE Jr; Ochs HD
A spontaneous multifocal subcutaneous fibromatosis is described in 6 pig-tailed macaques (Macaca nemestrina) with simian acquired immune deficiency syndrome (simian AIDS). The lesions consisted of a proliferation of vascular fibrous tissue that was infiltrated by lymphocytes and plasma cells. One animal also had retro
A 29-year-old Haitian man with the acquired immune deficiency syndrome (AIDS) developed disseminated cryptococcosis with an unusual cutaneous presentation. He had numerous hypopigmented papules over his face that clinically resembled molluscum contagiosum. To our knowledge, cutaneous cryptococcosis resembling molluscu
Physicians treating adolescents should take a complete sexual history, including sexual orientation and practices, to determine whether their patients are homosexually active. Lesbians are at very low risk for sexually transmitted diseases, but they do have other health concerns. Four general groups of conditions may
Unusual infections in the immunocompromised host often present a diagnostic dilemma to the physician. We describe a 29-year-old Haitian man with acquired immunodeficiency syndrome/pre-acquired immunodeficiency syndrome who died of phlegmonous gastritis.
Although the etiology of acute leukemia is largely unknown, some facets of the puzzle are becoming clarified. Recognition of important patterns in age-specific mortality rates has suggested that events early in life, perhaps even prenatally, may have an influence on developing leukemia in childhood. The racial differe
Lunardi-Iskandar Y; Georgoulias V; Allouche M; Rozenbaum W; Klatzmann D; Coll MC; Meyer P; Gluckman JC; Gentilini M; Jasmin C
T cell colonies were generated from the peripheral blood and bone marrow of 11 patients with acquired immune deficiency syndrome (AIDS), 17 normal male and female heterosexuals and seven clinically normal male homosexuals. Mononuclear cells were cultured in methylcellulose both in the absence and presence of interleuk
Natural killer (NK) cell activity was quantitated using 51Cr release from the human erythroleukemia cell line K562 in 39 heterosexual males, 60 asymptomatic homosexuals, 39 patients with persistent generalized lymphadenopathy (PGL), and 16 patients with acquired immunodeficiency syndrome (AIDS). PGL and AIDS patients
DeLorenzo LJ; Maguire GP; Wormser GP; Davidian MM; Stone DJ
The effectiveness of therapy with trimethoprim-sulfamethoxazole and/or pentamidine has not been fully evaluated in AIDS patients with Pneumocystis carinii pneumonia (PCP). Since recurrence of PCP is common, follow-up lung biopsy (15 transbronchial, one open) was performed as part of the clinical evaluation of 16 episo
The pulmonary complications of 70 patients with the acquired immunodeficiency syndrome (AIDS) are reviewed. Pneumocystis carinii pneumonia (PCP), present in 67 per cent of the patients, was diagnosed by fiberoptic bronchoscopy with transbronchial biopsies in all of the patients except two adults, who required open lun
Incidence data for the acquired immunodeficiency syndrome (AIDS) are presented on the basis of a surveillance file maintained by the San Francisco Bureau of Communicable Disease Control. The incidence of AIDS among residents of San Francisco rose steadily from the first case diagnosed in the last quarter of 1980 throu
Secondary immune deficiency generally involves more profound defects in cellular than humoral immunity. This type of immune deficiency occurs in acquired immunodeficiency syndrome (AIDS), cancer, malnutrition, aging and following immunosuppressive therapy. Immunorestorative therapies were developed for use in the immu
Mayo Clin Proc. 1985 Jul;60(7):473-87. Unique Identifier : AIDSLINE MED/85239154
Rosenow EC 3d; Wilson WR; Cockerill FR 3d
With few exceptions, pulmonary complications in the immunocompromised host will proceed to death unless the clinician intercedes. The differential diagnosis of diffuse pulmonary disease in this setting includes (1) infection, most commonly from opportunistic organisms; (2) recurrence or extension of the basic underlyi
We review the clinical features and histopathologic changes observed in 69 cases of lymphadenopathy in homosexual men. The most common pattern seen was that of florid reactive follicular hyperplasia (43 cases). A peculiar and distinctive lysis of the germinal centers, a phenomenon we have termed follicle lysis, was no
The majority of patients with congenital clotting disorders who use clotting factor concentrate exhibit lymphocyte subpopulation abnormalities. A subset of these patients develop lymph node enlargement (LNE), part of the spectrum of clinical disease associated with the acquired immune deficiency syndrome (AIDS). It is
Eight of 15 patients with acquired immunodeficiency syndrome (AIDS) and six of nine patients with lymphadenopathy syndrome (LAS) had paraproteins in their sera. Twelve of these 14 were IgG kappa; the other two had no demonstrable light chains. The relationship of the paraprotein to the pathogenesis of AIDS is not clea
Interleukin-2 ( IL-2 ) production as well as the response of lymphocytes to exogenous IL-2 was measured in asymptomatic homosexuals, patients with acquired immune deficiency syndrome (AIDS), and homosexuals with prodromal symptoms. IL-2 production following lectin stimul
Gluckman JC; Klatzmann D; Cavaille-Coll M; Brisson E; Messiah A; Lachiver D; Rozenbaum W
We have investigated the respective role of quantitative T lymphocyte subset abnormalities, interleukin-2 ( IL-2 ) production and responsiveness to IL-2, in the proliferative deficiency that is observed in acquired immune deficiency syndrome (AIDS) and Lymphadenopathy sy
Several investigators recently described a T lymphocyte subset abnormality (reversed helper/suppressor cell ratio) in haemophiliacs, especially following previous substitution therapy. We studied in vitro the potential effects of two commercial factor VIII concentrates on incorporation of 3H-thymidine by isolated huma
Alcocer-Varela J; Alarcon-Segovia D; Abud-Mendoza C
The production of the T cell lymphokine interleukin-2 ( IL-2 ) was found to impaired in all of seven male patients with AIDS or homosexuals with persistent generalized lymphadenopathy (AIDS related complex, AIDS-RC) whom we studied. Conversely the T cell response to IL-2
Presse Med. 1985 Jun 8;14(23):1282-6. Unique Identifier : AIDSLINE MED/85242617
Parnaud E; Bauer P
The common practice of sexual relations with many different and anonymous partners and the great variety of responsible micro-organisms account for the high incidence, growing complexity and uneasy prevention of sexually transmitted diseases of the digestive tract in male homosexuals. Syphilis, gonorrhoea, papillomas,
Am J Epidemiol. 1985 May;121(5):629-36. Unique Identifier : AIDSLINE MED/85248375
Goedert JJ; Biggar RJ; Winn DM; Mann DL; Byar DP; Strong DM; DiGioia RA; Grossman RJ; Sanchez WC; Kase RG; et al
In June 1982, sexual and other behavioral patterns were examined in 245 homosexual men in relationship to T-lymphocyte phenotypes that are characteristic of the acquired immunodeficiency syndrome (AIDS). Mean helper T-cell counts in New York City (579 +/- 32 cells/mm3) and Washington, DC, homosexual men with sexual co
Am J Epidemiol. 1985 May;121(5):637-44. Unique Identifier : AIDSLINE MED/85248376
Goedert JJ; Biggar RJ; Winn DM; Mann DL; Byar DP; Strong DM; DiGioia RA; Grossman RJ; Sanchez WC; Kase RG; et al
In June 1982, the sexual practices of 245 homosexual male outpatients of private physicians were evaluated in relationship to decreased numbers of helper T lymphocytes, an abnormality that is characteristic of the acquired immunodeficiency syndrome (AIDS). Three risk groups were defined a priori--85 high-risk men from
Hinuma S; Honda S; Tsukamoto K; Sugamura K; Hinuma Y
Six human T cell lines HAMA, KUN, KAN, TCL-Haz, TCL-Ter, and TCL-Mor, which were transformed by a retrovirus, human T-cell leukaemia virus (HTLV), constitutively produced plasminogen activators (PAs) in culture supernatants. The amount of PAs produced varied among the cell lines. The PAs were distinguished by immunoch
van den Ouweland AM; Breuer ML; Steenbergh PH; Schalken JA; Bloemers HP; Van de Ven WJ
Feline and human genetic sequences, homologous to the v-sis gene of simian sarcoma virus, have been isolated from cosmid gene libraries and characterized by restriction endonuclease analysis. Comparison of the two loci revealed their related structural organization. In both loci, similar unique genetic sequences were
Kinoshita K; Amagasaki T; Ikeda S; Suzuyama J; Toriya K; Nishino K; Tagawa M; Ichimaru M; Kamihira S; Yamada Y; et al
We report the clinical, hematologic, and immunologic features of 18 preleukemic adult T cell leukemia (pre-ATL) cases with abnormal T lymphocytosis induced by human adult T cell leukemia-lymphoma virus (HTLV/ATLV). The patients were from the Nagasaki district, which is one of the most endemic areas of ATL in
Testing for antibody to human T-lymphotropic retrovirus (HTLV-III) was carried out in 448 participants in the Vancouver Lymphadenopathy-AIDS (acquired immune deficiency syndrome) Study. The overall prevalence rate of seropositivity was 34%. Of 130 seronegative subjects followed for an average of 8.5 months, 14 became
Can Med Assoc J. 1985 Jul 1;133(1):28-32. Unique Identifier : AIDSLINE MED/85227778
Boyko WJ; Schechter MT; Jeffries E; Douglas B; Maynard M; O'Shaughnessy M
In a study of 394 homosexual men recruited at the primary care level the prevalence of antibody to human T-lymphotropic retrovirus (HTLV-III) was higher among those with lymph node enlargement than among controls. The degree of abnormal immune function, as shown by abnormalities in immunoglobulin levels, immune comple
Testing for antibody to human T-lymphotropic retrovirus (HTLV-III) was carried out in five groups of homosexual men: 250 without lymphadenopathy (control group), 37 with slight or nonpersistent lymph node enlargement (intermediate group), 141 with persistent generalized lymphadenopathy, 32 with persistent generalized
Cancer. 1985 Aug 1;56(3):495-9. Unique Identifier : AIDSLINE MED/85227903
Clark JW; Hahn BH; Mann DL; Wong-Staal F; Popovic M; Richardson E; Strong DM; Lofters WS; Blattner WA; Gibbs WN; et al
The human T-cell leukemia virus type-I (HTLV-I) is a unique, exogenous, horizontally transmitted retrovirus which is T-cell tropic, and has been associated with a specific type of aggressive leukemia/lymphoma of mature T-cell origin. In a survey of lymphoid malignancies in Jamaica
Cancer. 1985 Aug 1;56(3):524-30. Unique Identifier : AIDSLINE MED/85227909
Rubin CM; Burke BA; McKenna RW; McClain KL; White JG; Nesbit ME Jr; Filipovich AH
The clinical and pathologic findings of four patients with Chediak-Higashi syndrome in the accelerated phase were studied in order to clarify the nature of this enigmatic process. Fever, lymphadenopathy, hepatosplenomegaly, and cytopenias were present in every patient. All cases demonstrated extensive parenchymal infi
Cancer Res. 1985 Jul;45(7):3374-7. Unique Identifier : AIDSLINE MED/85228046
Robert-Guroff M; Clark JW
Monoclonal antibody HT462 recognizes a human T-cell leukemia virus type I (HTLV-I)-associated Mr 52,000 glycoprotein (HA-gp52), which is found on the surface of HTLV-infected cells. Whether HA-gp52 is encoded by the virus or by the infected cells has not yet been established. Using monoclonal HT462 in a competitive bi
The location of cis-acting regulatory sequences within the long terminal repeat (LTR) of the human T cell lymphotropic virus type III (HTLV-III/LAV) was determined. An enhancer element capable of increasing the rate of transcription from a heterologous promoter, irrespective of distance and orientation, is located bet
Crowl R; Ganguly K; Gordon M; Conroy R; Schaber M; Kramer R; Shaw G; Wong-Staal F; Reddy EP
The envelope gene of HTLV-III, the retrovirus directly linked to AIDS, encodes a protein of 856 amino acids. Our sequence analysis of the cloned HTLV-III (HXB-3) env gene and its comparison with other isolates reveal significant divergence, especially in the external portion of this protein. A large segment of the env
The occurrence of HTLV-III antibodies in a voluntary group of 175 homosexual men in a low risk AIDS area was studied, and the findings were correlated to clinical, virological, immunological and lifestyle parameters. Fifteen of 175 men had HTLV-III antibodies; two of these had AIDS, five had LAS and two had enlarged l
Inversion of the normal ratio of helper/inducer (Th) to suppressor/cytotoxic (Ts) T lymphocytes is a characteristic finding in symptomatic and presymptomatic patients with acquired immunodeficiency syndrome (AIDS). As an interim measure to prevent transmission of AIDS via blood transfusion, the Stanford Blood Center p
Shimotohno K; Takano M; Miwa M; Hoshino H; Ito H; Sugimura T
A splice donor site of pX mRNA of human T-cell leukemia virus type I was elucidated by analyzing a cDNA clone of poly A+ RNA isolated from cat fibroblast cells infected with the virus. The donor site was located near the 5 end of the env gene. The putative N-terminal amino acid sequence of the pX protein was deduced
Katamine S; Sugiyama H; Moriuchi R; Miyamoto T; Hino S
The immunological cross-reactivity of human T-cell leukemia virus type I (HTLV-I)-related sera with lymphadenopathy virus (LAV) was investigated. The sera tested were obtained from 36 adult T-cell leukemia patients, 182 HTLV-I carriers, and 284 control individuals in Nagasaki. Two test methods were utilized: indirect
Nishida J; Yoshikura H; Okabe T; Urabe A; Takaku F
Interferon(IFN)-alpha and -beta strongly inhibited syncytia formation of human T-cell leukemia virus (HTLV). They also inhibited transmission of HTLV to normal human fibroblasts. These phenomena suggest a physiological role of IFNs in defense against HTLV infection.
The acquired immunodeficiency syndrome (AIDS) is a disease which is characterized by a profound defect in cell-mediated immunity leading to opportunistic infections and unusual neoplasms such as Kaposi s sarcoma. It is caused by a retrovirus of the human T cell leukemia/lymphoma virus family and has been termed HTLV-I
Int J Cancer. 1985 Jun 15;35(6):749-51. Unique Identifier : AIDSLINE MED/85233508
Kondo T; Nonaka H; Miyamoto N; Yoshida R; Matsue Y; Ohguchi Y; Inouye H; Komoda H; Hinuma Y; Hanaoka M
The yearly incidence of ATLL in the Uwajima district is 6.6 patients per 100,000 inhabitants aged over 40. The yearly morbidity rate from ATLL of persons in this district who are positive for HTLV-antibody and older than 40 is 1 patient per 1,631. Familial occurrence was observed in 9/38 families available for pedigre
Int J Cancer. 1985 Jun 15;35(6):763-7. Unique Identifier : AIDSLINE MED/85233510
Biggar RJ; Johnson BK; Oster C; Sarin PS; Ocheng D; Tukei P; Nsanze H; Alexander S; Bodner AJ; Siongok TA; et al
The prevalence of antibodies against HTLV-III and -I was studied among populations of 6 distinctly different regions of Kenya , an equatorial African country in which AIDS has rarely been observed. Overall, 21% of subjects had ELISA reactions suggesting the presence of antibody again
Neurath AR; Strick N; Sproul P; Baker L; Rubinstein P; Stevens CE; Taylor P; Gallo RC; Gold JW; Lee YS; et al
Human T-cell lymphotropic viruses designated HTLV III or LAV are considered to represent the causative agent(s) of the acquired immunodeficiency syndrome (AIDS). Individuals who have been infected with these viruses may generally be identified on the basis of a positive serological test for antibodies against the prot
14 patients with hemophilia were studied for the distribution of T cell subsets, the presence of antibody to lymphadenopathy-associated or human T lymphotropic virus type III (LAV/HTLV-III), and their responsiveness in autologous mixed lymphocyte reactions. In addition, mitogen and alloantigen responsiveness and Inter
We studied the effects of sera from patients with the acquired immunodeficiency syndrome (AIDS) on interleukin-2 ( IL-2 ) production to help elucidate the mechanism of immunodeficiency. Compared with sera from healthy controls, sera from AIDS patients suppressed phytohem
Immune regulation: what immunodeficiency disease has taught us is reviewed by discussing three immuno-deficiency disorders. Hypogammaglobulinemia, the first documented primary immunodeficiency disorder, has a well defined and uniform clinical presentation which reflects a variety of underlying abnormalities involving
Tomita S; Ambrus JL Jr; Volkman DJ; Longo DL; Mitsuya H; Reitz MS Jr; Fauci AS
A human T cell leukemia/lymphoma virus (HTLV)-I-infected B cell clone expressed Tac antigen on its cell surface and responded to recombinant interleukin 2 ( IL-2 ) by increased production of IgM without any increase in proliferation. Anti-Tac antibody completely inhibite
We studied patients with transfusion-associated acquired immunodeficiency syndrome (AIDS) and their blood donors for serologic evidence of infection with human T-cell lymphotropic virus type III/lymphadenopathy-associated virus with two enzyme-linked immunosorbent assays and a Western blot assay. All 19 patients with
McGrath KM; Thomas KB; Herrington RW; Turner PJ; Taylor L; Ekert H; Schiff P; Gust ID
In a group of 126 Australian patients with haemophilia, who were receiving lyophilized clotting-factor concentrates prepared from locally collected plasma, a high prevalence of antibody to human T-cell lymphotropic virus III (HTLV-III) was demonstrated in those with severe disease. Patients with moderate or mild disea
Nature. 1985 Jun 20-26;315(6021):665-6. Unique Identifier : AIDSLINE MED/85240549
Ben-Ishai Z; Haas M; Triglia D; Lee V; Nahmias J; Bar-Shany S; Jensen FC
Epidemiological studies of the human T-cell leukaemia/lymphoma virus type I (HTLV-I), a type-C retrovirus of the human T-lymphotropic virus family, have used serological surveys to identify population subgroups possessing a high prevalence of naturally occurring HTLV-I-specific antibodies. Studies carried out to delin
Human T-lymphotropic virus type III (LAV, HTLV-III) is aetiologically linked to acquired immune deficiency syndrome (AIDS) and persistent general lymphadenopathy (PGL). Specific radioimmunoassays (RIA), enzyme-linked assays, immunofluorescence assays (IFA) and immunoblotting techniques are being used widely to detect
The isolation of the human T-cell leukaemia (lymphotropic) virus type III (HTLV-III or lymphadenopathy-associated virus) from cells of many patients with acquired immune deficiency syndrome (AIDS) presented the first evidence that the virus was the aetiological agent of the disease. Subsequent seroepidemiological stud
Britton CB; Mesa-Tejada R; Fenoglio CM; Hays AP; Garvey GG; Miller JR
Progressive thoracic myelopathy occurred in a patient with AIDS. Concurrent opportunistic infections included disseminated systemic cytomegalovirus , aspergillosis, and cutaneous herpes simplex virus (HSV). At autopsy, immune stains indicated that the myelopathy was caused by HSV ty
Proc Natl Acad Sci U S A. 1985 Jul;82(13):4539-43. Unique Identifier : AIDSLINE MED/85242721
Folks T; Benn S; Rabson A; Theodore T; Hoggan MD; Martin M; Lightfoote M; Sell K
We have developed a continuous human T-cell line (A3.01) for the study of acquired immunodeficiency syndrome (AIDS)-associated retrovirus that mimics normal peripheral blood lymphocytes in susceptibility to viral cytopathic effect without the need for cell activation or conditioned medium. Following infection, substan
Saxinger WC; Wantzin GL; Thomsen K; Hoh M; Gallo RC
10 of 68 CTCL (cutaneous T-cell lymphoma) patients without features of ATLL had antibodies against HTLV-I (human T-cell leukaemia virus, type I). The titre of antibody in these positive patients was generally much lower than that seen in cases of ATLL (adult T-cell leukaemia/lymphoma); geometric mean of 80 for CTCL vs
The putative transforming protein of the type I human T-cell leukemia virus (HTLV-1) is a 40-kilodalton protein encoded by the X region and is termed p40XI. On the basis of both subcellular fractionation techniques and immunocytochemical analysis, it is now shown that p40XI is a nuclear protein with a relatively short
Science. 1985 Jun 21;228(4706):1430-4. Unique Identifier : AIDSLINE MED/85244593
Sodroski J; Rosen C; Goh WC; Haseltine W
Human T-cell leukemia viruses type I and II (HTLV-I and -II) exhibit several features characteristic of this retroviral family: the presence of an x-lor gene encoding a nuclear protein, transformation properties suggesting the involvement of a virus-associated trans-acting factor, and transcriptional trans-activation
Science. 1985 Jun 28;228(4707):1532-4. Unique Identifier : AIDSLINE GENBANK/M10085
Seiki M; Hikikoshi A; Taniguchi T; Yoshida M
Human T-cell leukemia virus type I (HTLV-I) is an etiological agent of adult T-cell leukemia. A viral gene pX encodes for p40X and it has been proposed that this protein trans-activates the viral long terminal repeat and possibly some cellular genes; this activation may be associated with T-cell transformation. The me
Science. 1985 Jun 28;228(4707):1534-7. Unique Identifier : AIDSLINE MED/85244607
Wachsman W; Golde DW; Temple PA; Orr EC; Clark SC; Chen IS
The human T-cell leukemia viruses (HTLV) are replication-competent retroviruses whose genomes contain gag, pol, and env genes as well as a fourth gene, termed x, which is believed to be the transforming gene of HTLV. The product of the x gene is now shown to be encoded by a 2.1-kilobase messenger RNA derived by splici
Chen IS; Slamon DJ; Rosenblatt JD; Shah NP; Quan SG; Wachsman W
The human T-cell leukemia viruses (HTLV) are associated with T-cell malignancies in man and will transform normal human T cells in vitro. The mechanism of malignant transformation by HTLV is unknown but appears to be distinct from that of other classes of retroviruses, which induce malignant transformation through vir
Human T-lymphotropic virus type III (HTLV-III) encodes a trans-acting factor that activates the expression of genes linked to the HTLV-III long terminal repeat. By functional mapping of complementary DNA transcripts of viral messenger RNA s the major functional domain of the gene encoding this factor was localized to
Sodroski J; Patarca R; Rosen C; Wong-Staal F; Haseltine W
The retrovirus involved in acquired immune deficiency syndrome (HTLV-III/LAV) contains a region that is necessary for stimulation of gene expression directed by the viral long terminal repeat. This region is located between nucleotides 5365 and 5607, immediately 5 to the envelope gene. A doubly-spliced message contai
Science. 1985 Aug 2;229(4712):482-5. Unique Identifier : AIDSLINE GENBANK/M10131
Hess JL; Clements JE; Narayan O
Visna virus is a pathogenic lentivirus of sheep that is related to human T-cell lymphotropic virus type III (HTLV-III), the probable etiologic agent of the acquired immune deficiency syndrome (AIDS). The transcriptional activity of visna virus promoter and enhancer sequences was studied by means of an assay based on t
Neuropathologic changes are described in eight fatal cases of the acquired immunodeficiency syndrome (AIDS), including four subjects who were i.v. drug abusers (two women, two men), two Haitian men, one bisexual man, and one women who had no known risk factors for AIDS. All cases had significant infections of the brai
Am Fam Physician. 1985 Jul;32(1):155-60. Unique Identifier : AIDSLINE MED/85248094
Christian ES; Craig JB; Muss HB; Christian RM; Michaelson RD
This syndrome should be suspected in patients with clinical features of lymphadenopathy, hepatosplenomegaly, hypercalcemia, bone lesions and circulating lymphocytes with pleomorphic nuclei. Most biopsy material has morphologic characteristics of intermediate or high-grade non-Hodgkins lymphoma. Antibody titers to huma
The specific immunophenotypic characterization of the hematologic malignant diseases has been obtained most commonly by the immunofluorescent technic. It requires a microscope with illuminator or the expensive flow cytometer that usually precludes morphologic assessment. It was compared with the indirect rosette assay
Am J Hematol. 1985 Jul;19(3):307-13. Unique Identifier : AIDSLINE MED/85248465
Perkins HA
Acquired Immunodeficiency Disease (AIDS) may be transmitted by transfusion of blood components, although the risk remains extremely small. This report reviews the evidence for transmission by transfusion, the risk in several different situations, and the steps blood banks have taken to prevent transfusion of blood fro
Mittelman A; Wong G; Safai B; Myskowski P; Gold J; Koziner B
Ninety patients were grouped according to three different forms of acquired immune deficiency syndrome (AIDS): Kaposi s sarcoma recent outbreak type (38), reactive lymphadenopathy (27), and opportunistic infections (17), and a fourth group of patients with classic Kaposi s sarcoma (8). All patients with classic Kaposi
A cohort of 6875 homosexual men, initially seen at the San Francisco City Clinic between 1978 and 1980, were studied to determine the incidence and prevalence of the acquired immunodeficiency syndrome, related conditions, and infection with the human T-lymphotropic virus, type III/lymphadenopathy-associated virus (HTL
We studied 56 patients with acquired immunodeficiency syndrome who underwent autopsy at the New York University Medical Center. We uncovered several entities that were not previously described or emphasized in prior series. These were as follows: (1) three cases of necrotizing arteritis with
We evaluated the immediate causes of death in 54 adults who underwent an autopsy and were diagnosed as having died of the acquired immunodeficiency syndrome between April 1980 and October 1983. The study group included 25 Haitians, 19 homosexual men, five intravenous drug abusers, two hemophiliacs (type A), and three
Lancet. 1985 Jun 29;1(8444):1480-2. Unique Identifier : AIDSLINE MED/85239422
Sandstrom EG; Kaplan JC; Byington RE; Hirsch MS
Phosphonoformate, an inhibitor of reverse transcriptase in a number of retroviruses, was shown to have a dose-related inhibitory effect on human T-cell lymphotropic virus type III (HTLV-III) replication in the H9 cell line in vitro. HTLV-III replication was eliminated at a concentration of 680 mumol, a non-cytotoxic d
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