14q+ abnormality with probable t(8;14)(q24;q32) in a young Haitian immigrant with acquired immunodeficiency syndrome and concomitant Burkitt's-like lymphoma. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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14q+ abnormality with probable t(8;14)(q24;q32) in a young Haitian immigrant with acquired immunodeficiency syndrome and concomitant Burkitt's-like lymphoma.

Cancer Genet Cytogenet. 1985 Aug;17(4):283-8. Unique Identifier : AIDSLINE MED/85254348
Gyger M; Laverdiere M; Gagnon A; Perreault C; Cousineau S; Forest L

Abstract: Cytogenetic analyses were carried out in a young Haitian immigrant with acquired immunodeficiency syndrome and concomitant Burkitt's-like lymphoma associated with massive bone marrow infiltration. A characteristic 14q+ abnormality was found in all bone marrow cells examined. Although chromosome abnormality involving band 8q24 was not evident in all the cells examined, some karyotypes show that the typical t(8;14)(q24;q32) is most probably present. No other complex rearrangements could be identified. This is the first report of concomitant acquired immunodeficiency syndrome and Burkitt's-like lymphoma in the Haitian community. Our cytogenetic findings provide further evidence for the role of specific chromosomal rearrangements in Burkitt's-like lymphoma oncogenesis in the setting of acquired immunodeficiency syndrome.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS/GENETICS Adult Burkitt's Lymphoma/*COMPLICATIONS/GENETICS Case Report Chromosome Abnormalities/*GENETICS *Chromosomes, Human, 13-15 *Chromosomes, Human, 6-12 Human Karyotyping Male Translocation (Genetics) JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDcomplications/geneticsadultburkitt'slymphoma/KWDcomplications/geneticscasereportchromosomeabnormalities/KWDgeneticsKWDchromosomes,human,13-15KWDchromosomes,human,6-12humankaryotypingmaletranslocation(genetics)journalarticle
851130
M85B0189

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