Myelodysplasia in the acquired immune deficiency syndrome. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Myelodysplasia in the acquired immune deficiency syndrome.

Am J Clin Pathol. 1985 Aug;84(2):144-52. Unique Identifier : AIDSLINE MED/85276092
Schneider DR; Picker LJ

Abstract: Certain new hematologic findings in eight homosexual or bisexual patients with the acquired immune deficiency syndrome (AIDS) are presented. All eight patients manifested a normochromic, normocytic anemia, and six of eight had granulocytopenia during their hospitalization. The other two had low-normal granulocyte counts. Bone marrow examination showed normocellular or hypercellular marrows with increased myeloid: erythroid ratios and increased numbers of megakaryocytes. All patients had abnormalities in maturation of all cell lines, most prominent in the granulocytic series. This constellation of features is similar to the findings in the myelodysplastic syndromes (preleukemia). The authors suggest that myelodysplasia in patients with AIDS results in ineffective hematopoiesis and contributes to the peripheral blood cytopenias found in these patients. Myelodysplasia could be a direct or indirect effect of human T-lymphotropic retrovirus-III (HTLV-III).
Keywords: Acquired Immunodeficiency Syndrome/BLOOD/*PATHOLOGY Adult Anemia/PATHOLOGY Blood Cell Count Bone Marrow/PATHOLOGY Bone Marrow Diseases/BLOOD/*PATHOLOGY Erythrocytes, Abnormal/PATHOLOGY Erythropoiesis Granulocytes/PATHOLOGY Hematopoiesis Human Male Megakaryocytes/PATHOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/blood/KWDpathologyadultanemia/pathologybloodcellcountbonemarrow/pathologybonemarrowdiseases/blood/KWDpathologyerythrocytes,abnormal/pathologyerythropoiesisgranulocytes/pathologyhematopoiesishumanmalemegakaryocytes/pathologyjournalarticle
851130
M85B0172

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