Human T-cell leukemia virus x gene. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Human T-cell leukemia virus x gene.

Cancer Res. 1985 Sep;45(9 Suppl):4550s-4552s. Unique Identifier : AIDSLINE MED/85254468
Wachsman W; Slamon D; Shimotohno K; Golde DW; Chen IS

Abstract: The human T-cell leukemia virus (HTLV) types I and II are associated with specific hematological cancers. These viruses rapidly transform normal T-lymphocytes in vitro. The mechanism of HTLV-induced leukemogenesis is unknown. Structural analysis of HTLV-I and HTLV-II has revealed sequences of unknown function, termed X, at the 3' end of the proviral genome. The distal two-thirds of the X sequences are highly conserved between HTLV-I and HTLV-II. We have shown that these conserved X sequences contain a gene, termed x, that is expressed in both HTLV-I and HTLV-II by identifying a subgenomic X RNA as well as the proteins encoded by these messages. The function of this unique x gene is unknown; however, its conservation and expression suggest that it may play a role in HTLV replication and in HTLV-induced leukemogenesis.
Keywords: Cell Line Cell Transformation, Neoplastic Cell Transformation, Viral Codon Gene Expression Regulation Genes, Structural Genes, Viral Human HTLV-BLV Viruses/*GENETICS/PHYSIOLOGY Oligopeptides/BIOSYNTHESIS Recombination, Genetic RNA, Messenger/GENETICS RNA, Viral/GENETICS Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. T-Lymphocytes/MICROBIOLOGY Transcription, Genetic Viral Proteins/BIOSYNTHESIS/GENETICS Virus Replication JOURNAL ARTICLE

KWDcelllinecelltransformation,neoplasticcelltransformation,viralcodongeneexpressionregulationgenes,structuralgenes,viralhumanhtlv-blvviruses/KWDgenetics/physiologyoligopeptides/biosynthesisrecombination,geneticrna,messenger/geneticsrna,viral/geneticssupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDt-lymphocytes/microbiologytranscription,geneticviralproteins/biosynthesis/geneticsvirusreplicationjournalarticle
851130
M85B0120

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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