Berlin ; New York : Springer-Verlag, 1985 ix, 266 p. : ill (Current topics in microbiology and immunology ; 115) Unique Identifier : AIDSLINE CAT/8508385
Despite decades of work showing retroviruses to be involved in leukemogenesis in a variety of animal and subhuman primate species, it has only been recently that a pathogenic retrovirus has been unequivocally demonstrated in humans. This virus, called HTLV (human T-cell leukemia-lymphoma virus), is a unique exogenous
The acquired immunodeficiency syndrome (AIDS) has emerged as one of the most extraordinary diseases in human history. The common denominator of the disease is a profound quantitative and qualitative deficiency of a specific subset of thymus-derived (T) lymphocytes, designated by the phenotypic marker T4. The immune de
Allen JR; Curran JW; Center for Infectious Diseases, Centers for Disease Control,; Atlanta, GA 30333
Epidemiology of the acquired immunodeficiency syndrome (AIDS) is discussed under the following headings and subheadings: opportunistic infections and Kaposi s sarcoma in homosexual men, surveillance of AIDS (definition of reporting cases; lymphadenopathy syndrome and the AIDS-related complex), disease trends and demog
Fauci AS; Lane HC; National Institute of Allergy and Infectious Diseases, National; Institutes of Health, Bethesda, MD 20205
The epidemiologic pattern of the acquired immunodeficiency syndrome (AIDS) suggested that this is a transmissible disease. An important clue to the underlying etiology came from the pattern of immunologic abnormalities that was consistently seen in patients with AIDS. The common denominator of the syndrome is a profou
Safai B; Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New; York, NY 10021
Kaposi s sarcoma (KS) and other neoplasms in acquired immunodeficiency syndrome (AIDS) are discussed under the following headings: history, epidemiology, clinical manifestations and course of the disease, histopathology, associated disorders, differential diagnosis, histogenesis, therapeutic modalities, and other neop
Abrams DI; Department of Medicine, University of California, San Francisco,; CA 94110
Lymphadenopathy syndrome in male homosexuals is discussed under the following headings: incidence, lymph node histopathology, clinical syndrome, laboratory evaluation, immunologic evaluation, virologic evaluation, and natural history. The differential diagnosis of diffuse lymphadenopathy in a homosexual man today incl
Kaposi s sarcoma (KS) was recognized in 1948 in Zaire , where it has probably always been endemic. In 1957 a relative frequency of KS of 9% of all biopsied cancers was found. There are fluctuations in incidence within the country, with a higher incidence in the east, where it was e
A total of 299 cases of Kaposi s sarcoma (KS) occurring in Zaire over a 21-year period have been reviewed in the Department of Pathology, Kinshasa University Hospital. Of these, 268 were localized in the skin (89,6%) with the majority (51.8%) in the lower limbs; 31 (10.4%) were lo
The exact etiology of Kaposi s sarcoma (KS) remains unknown. Certain observed features suggest a possible viral etiology, including: (a) the spontaneous regression of indolent forms; (b) the frequent occurrence of second primary malignancies; (c) the multifocal nature of KS. Electron microscopic studies have revealed
Previous studies have established an association between cytomegalovirus ( CMV ) and classic and endemic Kaposi s sarcoma (KS) which can be extended to include the epidemic form of KS. The identification of nucleic acid sequenc
The relationship between viruses and naturally occurring cancers, such as hepatocellular carcinoma and genital cancers, is of great importance to Africa. On the other hand, lymphomas, leukaemias and immunodeficiencies, although of less immediate public health importance, constitute an area of outstanding interest for
Childhood acute lymphosarcoma-cell leukaemia (CALSCL) accounts for 13-14% of all childhood leukaemias in Kenya . It occurs in temporal clusters in children aged 5-9 years, and an environmental leukaemogenic factor is therefore suspected. A study of children with acute leukaemia was c
Purtilo DT; Manolov G; Manolova Y; Harada S; Lipscomb H
The immune system has evolved under Darwinian pressures as a defence against ubiquitous viruses. Immune surveillance against viral antigens protects the normal host. Individuals with inherited or acquired immune-deficiency disorders can become vulnerable to ubiquitous viruses and neoplasms can ensue, such as B-cell ly
Marmor M; Des Jarlais DC; Friedman SR; Lyden M; el-Sadr W
Intravenous (IV) users of illicit drugs have accounted for 17% of AIDS cases seen in the United States . Previous research has shown that more than half of IV drug abusers entering a drug detoxification program in New York City had serologic evidence of exposure to the virus believed to
Virions resembling the AIDS-associated retroviruses HTLV-III and LAV were identified between pseudopods of dendritic reticulum cells in lymph nodes from 3 patients with prodromal AIDS. The virions are morphologically distinguishable from HTLV-I and HTLV-II and also from D-type retroviruses that are associated with the
Observation of clustering of adult T-cell leukaemia/lymphoma (ATL) in the coastal areas of southern Japan led to speculations about its association with an environmental agent. Human T-cell lymphoma/leukaemia virus (HTLV) was later identified as the probable causal agent in these an
Can Med Assoc J. 1985 Aug 15;133(4):293. Unique Identifier : AIDSLINE MED/85254189
Boyko WJ; Schechter MT; Constance P; Nitz R
Lymphocytopenia is often present in patients with acquired immune deficiency syndrome (AIDS) and has been suggested as a useful screening test for AIDS. Of 625 patients consecutively admitted to an acute care university teaching hospital 91 (15%) were found to have a lymphocyte count of less than 1 X 10(9)/L, and 25 (
Cancer Genet Cytogenet. 1985 Aug;17(4):283-8. Unique Identifier : AIDSLINE MED/85254348
Gyger M; Laverdiere M; Gagnon A; Perreault C; Cousineau S; Forest L
Cytogenetic analyses were carried out in a young Haitian immigrant with acquired immunodeficiency syndrome and concomitant Burkitt s-like lymphoma associated with massive bone marrow infiltration. A characteristic 14q+ abnormality was found in all bone marrow cells examined. Although chromosome abnormality involving b
A case of Kaposi s sarcoma in underlying acquired immunodeficiency syndrome (AIDS) with involvement of the colon and the terminal ileum is presented. The endoscopic and histological findings are described and the technical and clinical aspects of the results discussed.
Kestens L; Melbye M; Biggar RJ; Stevens WJ; Piot P; De Muynck A; Taelman H; De Feyter M; Paluku L; Gigase PL
Twenty-seven histologically confirmed Kaposi sarcoma (KS) patients resident in the Kivu Lake area of eastern Zaire were examined for immune competence. Only KS cases of the endemic African type have been observed in this high-incidence area. The median duration of the symptoms was
Zee CS; Segall HD; Rogers C; Ahmadi J; Apuzzo M; Rhodes R
A case of cerebral toxoplasmosis in a patient with acquired immune deficiency syndrome who was evaluated by both CT and magnetic resonance is reported. Magnetic resonance proved to be far more sensitive in detecting the intracranial lesions than CT.
Rapid and specific diagnosis of infections involving patients with acquired immunodeficiency syndrome (AIDS) is imperative. Toxoplasmosis is one of the most frequent causes of central nervous system disease in these patients. The authors present a case of cerebral toxoplasmosis in an AIDS patient, diagnosed by electro
In Saudi Arabia , a native patient with no known risk factors for the acquired immune deficiency syndrome (AIDS) developed both clinical and laboratory evidence of AIDS 2 years after receiving transfusion of 11 units of blood obtaine
Certain new hematologic findings in eight homosexual or bisexual patients with the acquired immune deficiency syndrome (AIDS) are presented. All eight patients manifested a normochromic, normocytic anemia, and six of eight had granulocytopenia during their hospitalization. The other two had low-normal granulocyte coun
Am J Hematol. 1985 Sep;20(1):31-40. Unique Identifier : AIDSLINE MED/85276245
Wang W; Herrod H; Presbury G; Wilimas J
Immunologic studies were performed on mononuclear cells from ten chronically transfused children with sickle cell disease, and the results were compared with those from five other groups: 21 sickle cell patients who were not receiving regular transfusions, 6 chronically transfused children with other forms of refracto
A total of 339 strains of the Mycobacterium avium-intracellulare-scrofulaceum complex were phage typed using our previously described technique and 11 typing phages. These included 235 strains of human origin obtained from state health laboratories in Virginia, Georgia , Florida, a
Single-agent intravenous vinblastine, 4 to 8 mg/week, was used to treat 38 patients with Kaposi s sarcoma related to the acquired immunodeficiency syndrome. The dose was titrated in relation to the total leukocyte count. Ten patients had an objective response, and 19 had stable disease during therapy. Apart from expec
Homosexual males at risk for acquired immune deficiency syndrome (AIDS) frequently present with peripheral lymphadenopathies that precede the opportunistic infections and neoplasias of this disease. Two homosexual males had enlarged salivary glands due to lymphadenopathies initially affecting intraparotid and perisubm
The prevalence of antibodies to human T-lymphotropic virus III was determined in acquired immunodeficiency syndrome (AIDS) risk groups by an enzyme linked immunosorbent assay and confirmatory tests in four different areas in West Germany . Twenty-four of 28 homosexual AIDS patients
Nyberg DA; Federle MP; Jeffrey RB; Bottles K; Wofsy CB
Disseminated infection from Mycobacterium avium-intracellulare (MAI) has recently been recognized as a common and serious complication of the acquired immunodeficiency syndrome (AIDS). The authors report the computed tomographic (CT) findings of 17 patients with AIDS and disseminated MAI referred for abdominal CT exam
We studied the demographic characteristics, drug use patterns, and sexual habits of intravenous (IV) drug abusers to further define this population at risk for acquired immunodeficiency syndrome (AIDS). Sixteen IV drug abuser patients with AIDS, 24 IV drug abuser patients with AIDS-related complex (ARC), and 14 IV dru
Maayan S; Wormser GP; Hewlett D; Miller SN; Duncanson FP; Rodriguez A; Perla EN; Koppel B; Rieber EE
Forty patients with acquired immunodeficiency syndrome (AIDS), 70% of whom were intravenous drug abusers (IVDAs), were seen over a 20-month period (July 1, 1981, through Feb 28, 1983). Most of the patients came from two inner-city sections of New York City and from nearby correctional facilities. Eighty-five percent o
Emerg Med Clin North Am. 1985 Aug;3(3):491-505. Unique Identifier : AIDSLINE MED/85257102
Aronchick J; Epstein D; Gefter WB; Miller WT
This article discusses the differential diagnosis of abnormal radiographic patterns most commonly seen in emergency department patients with chest disease. Conditions associated with trauma are also described.
Mayo Clin Proc. 1985 Sep;60(9):610-31. Unique Identifier : AIDSLINE MED/85266418
Wilson WR; Cockerill FR 3d; Rosenow EC 3d
In this second segment of our article on pulmonary disease in the immunocompromised host (ICH), we review the infections associated with pulmonary infiltrates in the ICH and the diagnostic approaches for both infectious and noninfectious conditions. Although certain immunologic defects may predispose patients to speci
AIDS is a disorder that the pediatrician must consider when evaluating children with a variety of clinical conditions, including overwhelming infection with a number of parasites. This article discusses these opportunistic parasitic infections, focusing on their link with AIDS.
Kleinerman ES; Ceccorulli LM; Zwelling LA; Twilley T; Herberman RB; Jacob J; Gelmann EP
The purpose of these studies was to determine whether peripheral blood monocytes from acquired immunodeficiency syndrome (AIDS) patients with Kaposi s sarcoma could be activated to lyse human tumor target cells in vitro. Monocytes were isolated and incubated for 24 hours in vitro with either medium (control), a crude
Henderson LE; Sowder R; Smythers G; Benveniste RE; Oroszlan S
A new D-type retrovirus originally designated SAIDS-D/Washington and here referred to as retrovirus-D/Washington (R-D/W) was recently isolated at the University of Washington Primate Center, Seattle, Wash., from a rhesus monkey with an acquired immunodeficiency syndrome and retroperitoneal fibromatosis. To better esta
Recently, abnormalities of cell-mediated immunity were found in hemophiliac patients receiving factor VIII concentrate therapy. Contradictory results were reported concerning cellular immune functions in hemophiliacs treated only with cryoprecipitate or fresh frozen plasma. Therefore, we evaluated the immunological st
Cancer Res. 1985 Sep;45(9 Suppl):4616s-4618s. Unique Identifier : AIDSLINE MED/85254484
Ranki A; Valle SL; Antonen J; Suni J; Jokipii L; Jokipii AM; Saxinger C; Krohn K
Clinical, microbiological, and lifestyle patterns in homosexual men showing in vitro immunological abnormalities were studied and related to the susceptibility to human T-lymphotropic virus type III (HTLV-III) infection. In a cohort of male homosexual volunteers in
Tedder TF; Crain MJ; Kubagawa H; Clement LT; Cooper MD
The differentiation status of T and B cells was evaluated in patients with common variable immunodeficiency (CVI), selective IgA deficiency (IgA), X-linked agammaglobulinemia (XLA), and the acquired immune deficiency syndrome (AIDS) with the use of conventional lymphocyte markers and four new monoclonal antibodies tha
Antibodies to antigens associated with human T cell leukaemia virus type I (HTLV I) in Swedish adult leukaemia patients and blood donors were sought with a sensitive screening test using membrane antigen prepared from virus producing cells (MA-ELISA). Four persons (one ALL, one AML and two healthy blood donors) out of
Information regarding the development of diverse diseases associated with EBV virus in immune deficient patients has been gained by studying males with XLP, and their families. Multiple immune defenses normally protect against the ubiquitous EBV. Depending on the type and degree of inherited or acquired immunodeficien
Br Med J (Clin Res Ed). 1985 Jul 20;291(6489):165-6. Unique Identifier : AIDSLINE MED/85253765
Aiuti F; Rossi P; Sirianni MC; Carbonari M; Popovic M; Sarngadharan MG; Contu L; Moroni M; Romagnani S; Gallo RC
A study was performed to assess the prevalence of specific antibodies to human T cell lymphotropic retrovirus (HTLV-III) in patients with lymphadenopathy syndrome, patients with the acquired immune deficiency syndrome (AIDS), and those at risk of AIDS. Serum samples were obtained from these groups and from healthy con
Can Med Assoc J. 1985 Aug 15;133(4):286-92. Unique Identifier : AIDSLINE MED/85254188
Schechter MT; Boyko WJ; Jeffries E; Willoughby B; Nitz R; Constance P; Weaver M; Wiggs B; O'Shaughnessy M
Results of testing for antibody to human T-lymphotropic virus (HTLV-III) and absolute numbers of helper T cells in 219 participants in the Vancouver Lymphadenopathy-AIDS (acquired immune deficiency syndrome) Study were analysed. The mean absolute helper T-cell counts in the 141 HTLV-III seronegative and the 78 seropos
Cancer Res. 1985 Aug;45(8):3471-6. Unique Identifier : AIDSLINE MED/85254385
Blakeslee JR Jr; Yamamoto N; Hinuma Y
Human T-cell leukemia virus type I was induced by N-methyl-N -nitro-N-nitrosoguanidine (MNNG) and 5-iodo-2 -deoxyuridine (ldUrd) in the MT-1 cell line. Virus expression was monitored by immunofluorescence microscopy with GIN-14, mouse monoclonal antibodies directed toward Mr 19,000 and Mr 28,000 protein-specific virus
Cancer Res. 1985 Sep;45(9 Suppl):4534s-4538s. Unique Identifier : AIDSLINE MED/85254465
Essex M; McLane MF; Kanki P; Allan J; Kitchen L; Lee TH
T-lymphotropic retroviruses of cats cause lymphopenia and immunosuppression and represent the major cause of death in that species. Similarly HTLV-I which is T4 tropic is associated with an increased risk for development of infectious disease in regions where the virus is endemic. Since HTLV-I is also believed to be t
Cancer Res. 1985 Sep;45(9 Suppl):4539s-4544s. Unique Identifier : AIDSLINE MED/85254466
Wong-Staal F; Ratner L; Shaw G; Hahn B; Harper M; Franchini G; Gallo R
The generic name for a family of human T-lymphotropic retroviruses is HTLV. Two of the three members in this family have been linked etiologically to human diseases: HTLV-I with adult T-cell leukemia and HTLV-III with the acquired immunodeficiency syndrome. In addition to their T-cell tropism and a number of other com
Cancer Res. 1985 Sep;45(9 Suppl):4550s-4552s. Unique Identifier : AIDSLINE MED/85254468
Wachsman W; Slamon D; Shimotohno K; Golde DW; Chen IS
The human T-cell leukemia virus (HTLV) types I and II are associated with specific hematological cancers. These viruses rapidly transform normal T-lymphocytes in vitro. The mechanism of HTLV-induced leukemogenesis is unknown. Structural analysis of HTLV-I and HTLV-II has revealed sequences of unknown function, termed
The human T-cell lymphotropic virus (HTLV) family includes members associated with T-cell cancers (HTLV-I and HTLV-II) as well as the etiological agent of the acquired immunodeficiency syndrome (HTLV-III). Molecular clones of these viruses were used in heteroduplex mapping experiments to study their structural and evo
Cancer Res. 1985 Sep;45(9 Suppl):4559s-4562s. Unique Identifier : AIDSLINE MED/85254470
Waldmann TA; Longo DL; Leonard WJ; Depper JM; Thompson CB; Kronke M; Goldman CK; Sharrow S; Bongiovanni K; Greene WC
Interleukin-2 ( IL-2 ) is a lymphokine synthesized by some T-cells following activation. Resting T-cells do not express IL-2 receptors, but receptors are rapidly expressed on T-cells following interaction of antigens, mitogens, or monoclonal antibodies with the antigen-s
Cancer Res. 1985 Sep;45(9 Suppl):4563s-4567s. Unique Identifier : AIDSLINE MED/85254471
Greene WC; Depper JM; Crabtree GR; Rudikoff S; Pumphrey J; Robb RJ; Kronke M; Svetlik P; Peffer NJ; Waldmann TA; et al
Complementary DNAs corresponding to the human receptor for interleukin 2 ( IL-2 ) have been molecularly cloned, sequenced, and expressed in COS-1 cells. The human genome appears to contain a single structural gene for this receptor; however, when transcribed at least two
Cancer Res. 1985 Sep;45(9 Suppl):4574s-4577s. Unique Identifier : AIDSLINE MED/85254473
Sarngadharan MG; diMarzo Veronese F; Lee S; Gallo RC
A high correlation was found among antibodies to human T-cell leukemia virus type III (HTLV-III), acquired immunodeficiency syndrome, and acquired immunodeficiency syndrome-related complex. With the Western blot technique the antigens (shown as proteins with molecular weights given in thousands) in HTLV-III lysates re
Cancer Res. 1985 Sep;45(9 Suppl):4578s-4582s. Unique Identifier : AIDSLINE MED/85254474
Burny A; Bruck C; Cleuter Y; Couez D; Deschamps J; Ghysdael J; Gregoire D; Kettmann R; Mammerickx M; Marbaix G; et al
The bovine leukemia virus is the etiological agent of a chronic lymphatic leukemia in cows, sheep, and goats. The same virus seems to induce a kind of wasting disease in experimentally infected rabbits. Antibodies to highly purified bovine leukemia viral Mr 51,000 glycoprotein and Mr 24,000 protein cross-react with hu
Cancer Res. 1985 Sep;45(9 Suppl):4583s-4587s. Unique Identifier : AIDSLINE MED/85254475
Mitsuya H; Matsushita S; Harper ME; Broder S
Acquired immunodeficiency syndrome (AIDS) is a pandemic immunosuppressive disease that predisposes to life-threatening opportunistic infections and unusual forms of neoplasms. A recently discovered member of the human T-lymphotrophic virus (HTLV) family, designated HTLV-III, has been shown to be the etiological agent
Cancer Res. 1985 Sep;45(9 Suppl):4588s-4591s. Unique Identifier : AIDSLINE MED/85254476
Markham PD; Salahuddin SZ; Popovic M; Patel A; Veren K; Fladager A; Orndorff S; Gallo RC
During the last 2 yr more than 100 independent isolates of human T-cell leukemia virus type III have been obtained in this laboratory. Most isolates were from peripheral blood T-lymphocytes established in cell culture from acquired immunodeficiency syndrome (AIDS) and acquired immunodeficiency syndrome-related complex
Cancer Res. 1985 Sep;45(9 Suppl):4592s-4594s. Unique Identifier : AIDSLINE MED/85254477
Prince AM; Horowitz B; Dichtelmueller H; Stephan W; Gallo RC
Human T-lymphotropic retrovirus type III (HTLV-III) can be quantitatively assayed for infectivity by inoculation of serial dilutions into cultures of the H-9 cell line and testing for reverse transcriptase in the culture supernatants. Sequential harvests revealed that 14 days of incubation of cultures fed twice weekly
Cancer Res. 1985 Sep;45(9 Suppl):4595s-4597s. Unique Identifier : AIDSLINE MED/85254478
Zagury D; Fouchard M; Cheynier R; Bernard J; Cattan A; Salahuddin SZ; Sarin PS
The development of acquired immunodeficiency syndrome or of acquired immunodeficiency syndrome-related complex by transmission of human T-lymphotropic retrovirus III by semen has previously been implicated by epidemiological studies. In vitro investigations were performed on mononuclear cells obtained from the semen o
Cancer Res. 1985 Sep;45(9 Suppl):4598s-4601s. Unique Identifier : AIDSLINE MED/85254479
Blattner WA; Biggar RJ; Weiss SH; Clark JW; Goedert JJ
The discovery of HTLV-I opened the way for the subsequent recognition of other human retroviruses. HTLV-I is linked to an aggressive T-cell cancer. The availability of a marker for the AIDS agent, HTLV-III, has substantially enhanced our ability to define the nature of the AIDS epidemic, its clinical and subclinical m
Cancer Res. 1985 Sep;45(9 Suppl):4602s-4604s. Unique Identifier : AIDSLINE MED/85254480
Curran JW; Morgan WM; Starcher ET; Hardy AM; Jaffe HW
The incidence of acquired immunodeficiency syndrome (AIDS) in the United States has increased rapidly since the first reports in 1981. Highest estimated rates are among single (never-married) men in Manhattan and San Francisco, men and women who have abused drugs intravenously, and per
Cancer Res. 1985 Sep;45(9 Suppl):4609s-4611s. Unique Identifier : AIDSLINE MED/85254482
Biberfeld G; Bottiger B; Karlsson A; Sandstrom E; Morfeldt-Mansson L; Blomback M; Nilsson IM; Wiechel B; Saxinger C; Gallo R
Two hundred and three homosexual (HS) men and 114 hemophiliacs in Sweden were examined for serum antibodies to human T-lymphotropic virus type III (HTLV-III) and for alterations of T-lymphocyte subsets. Sera were screened for HTLV-III antibodies by an enzyme-linked immunosorbent as
Cancer Res. 1985 Sep;45(9 Suppl):4612s-4615s. Unique Identifier : AIDSLINE MED/85254483
Krohn KJ; Antonen J; Valle SL; Kazakevicius R; Saxinger C; Gallo RC; Ranki A
Clinical, immunological, microbiological, virological, and lifestyle parameters were followed in 200 homosexual men living in Finland . The subjects were seen at 3- to 6-month intervals starting in summer 1983. Human T-cell lymphotro
Sera from 50 Japanese hemophiliacs were screened for antibodies to human T-lymphotropic retrovirus types I and III (HTLV-I and III). As a whole, antibody to HTLV-I, antibody to HTLV-III, and antibodies to HTLV-I and -III were detected in sera from 2, 17, and 6 hemophiliacs, respectively. Among them, two hemophiliacs d
Cancer Res. 1985 Sep;45(9 Suppl):4624s-4626s. Unique Identifier : AIDSLINE MED/85254487
Saxinger C; Levine PH; Dean A; Lange-Wantzin G; Gallo R
Of 75 sera collected in the West Nile district of Uganda over a 1-year period between 1972 and 1973, 50 (66%) had antibody reactivity to human T-cell lymphotropic virus subgroup III (HTLV-III) at low titer levels. Sera were initially screened by HTLV-III enzyme linked immunosorbent
Cancer Res. 1985 Sep;45(9 Suppl):4633s-4636s. Unique Identifier : AIDSLINE MED/85254490
de-The G; Gessain A; Gazzolo L; Robert-Guroff M; Najberg G; Calender A; Peti M; Brubaker G; Bensliman A; Fabry F; et al
The prevalence of antibodies detected by ELISA against human T-lymphotropic viruses, type I (HTLV-I) and type III (HTLV-III-LAV), is described in a comparative serosurvey in the French West Indies and African countries. The data confirm that the Caribbean basin is endemic for HTLV-I. In this region, HTLV-I antibody pr
Cancer Res. 1985 Sep;45(9 Suppl):4646s-4648s. Unique Identifier : AIDSLINE MED/85254493
Safai B; Sarngadharan MG; Koziner B; Godbold J; Myskowski PL; Cunningham-Rundles S; Johnson K; Gold J; Krown S; Dupont B
Kaposi s sarcoma (KS) is seen with increased frequency in the course of the epidemic of acquired immune deficiency syndrome. In this population, KS has manifested in an aggressive and more disseminated fashion as compared to the classical type. As the epidemic of acquired immune deficiency syndrome continues to spread
Cancer Res. 1985 Sep;45(9 Suppl):4649s-4651s. Unique Identifier : AIDSLINE MED/85254494
Groopman JE
We have studied the clinical and laboratory manifestations of infection with human T-cell lymphotropic virus type III in various epidemiological cohorts. The spectrum of infection ranges from an asymptomatic but apparently contagious carrier state to severe immunodeficiency with opportunistic infections and neoplasms.
Cancer Res. 1985 Sep;45(9 Suppl):4652s-4654s. Unique Identifier : AIDSLINE MED/85254495
Gold JW
Infectious complications are the cause of death in the overwhelming majority of patients with the acquired immunodeficiency syndrome (AIDS). These infectious complications are outstanding in severity and number. Infecting organisms are mainly those which take advantage of defective T-cell function. Many cause latent i
Cancer Res. 1985 Sep;45(9 Suppl):4655s-4658s. Unique Identifier : AIDSLINE MED/85254496
Kaplan MH; Pahwa SG; Popovic M; Sarngadharan MG; Gallo RC
Since 1981, 75 patients have been seen at our hospital with human T-cell lymphotropic virus type III (HTLV-III) infection. We have classified their clinical presentation into Groups 0 to 6. Groups 0 to 3 all have antibody to the Mr 41,000 protein of HTLV-III. Group 0 has no evident disease (9 patients), Group 1 has ly
Cancer Res. 1985 Sep;45(9 Suppl):4662s-4664s. Unique Identifier : AIDSLINE MED/85254498
Jaffe ES; Clark J; Steis R; Blattner W; Macher AM; Longo DL; Reichert CM
Human T-cell leukemia/lymphoma virus I can transform mature T-lymphocytes in vitro and is associated with the human T-cell cancer, adult T-cell leukemia/lymphoma. Adult T-cell leukemia/lymphoma is a distinct clinicopathological entity associated with leukemia, lymphadenopathy, hepatosplenomegaly, skin lesions, hyperca
Cancer Res. 1985 Sep;45(9 Suppl):4665s-4670s. Unique Identifier : AIDSLINE MED/85254499
Biberfeld P; Porwit-Ksiazek A; Bottiger B; Morfeldt-Mansson L; Biberfeld G
Lymph node biopsies from 43 male homosexuals with persistent generalized lymphadenopathy and from ten acquired immunodeficiency syndrome patients, all with serum antibodies to human T-cell leukemia virus III, were studied with regard to histopathology, immunohistology, and T-cell subsets in cell suspensions. All acqui
Cancer Res. 1985 Sep;45(9 Suppl):4671s-4673s. Unique Identifier : AIDSLINE MED/85254500
Pompidou A; Delsaux MC; Telvi L; Mace B; Coutance F; Falkenrodt A; Lang JM
Isoprinosine and Imuthiol are immunomodulators with a unique effect on T-cells. The possibility of using them in treating patients with acquired immunodeficiency syndrome related complex (ARC) was initially examined regarding their in vitro effects on peripheral blood mononuclear cells. In six ARC patients Isoprinosin
Cancer Res. 1985 Sep;45(9 Suppl):4674s-4676s. Unique Identifier : AIDSLINE MED/85254501
Lane HC; Masur H; Gelmann EP; Fauci AS
The immune systems of patients with acquired immunodeficiency syndrome are characterized by a profound defect in the number and function of helper/inducer T-lymphocytes, particularly at the level of soluble antigen recognition. Due to this selective yet profound defect in the immune system, these patients are prone to
Cancer Res. 1985 Sep;45(9 Suppl):4677s-4684s. Unique Identifier : AIDSLINE MED/85254502
Chandra P; Vogel A; Gerber T
Compared to other T-lymphotropic human retroviruses, human T-cell leukemia (lymphotropic) virus I (HTLV-I) and HTLV-II, the acquired immunodeficiency syndrome (AIDS)-associated virus, HTLV-III, is a nontransforming cytopathic virus without immortalizing activity. Thus the virus replication is an important event in the
Cancer Res. 1985 Sep;45(9 Suppl):4685s-4688s. Unique Identifier : AIDSLINE MED/85254503
Yarchoan R; Mitsuya H; Matsushita S; Broder S
The recent discovery of HTLV-III, a cytopathic member of the family of human T-cell lymphotropic viruses (HTLV), and its identification as the etiological agent of acquired immunodeficiency syndrome (AIDS) have important implications for the treatment of this disorder. The pathogenesis of AIDS involves the destruction
The continuous increase in the number of acquired immunodeficiency syndrome (AIDS) cases for whom no effective therapy is currently possible mandates attempts at developing primary prevention by a vaccine. Two basic unknowns are considered important: the identification of virus-exposed, protected individuals; and the
Cancer Res. 1985 Sep;45(9 Suppl):4700s-4705s. Unique Identifier : AIDSLINE MED/85254507
Bolognesi DP; Fischinger PJ
Overwhelming evidence has been obtained over the past 2 years that human T-cell leukemia virus type III (HTLV-III) is the primary cause of acquired immunodeficiency syndrome. The direct cytopathic effect of the virus on T4 helper cells demonstrated in vitro is probably responsible for the depletion of this critical po
Sonigo P; Alizon M; Staskus K; Klatzmann D; Cole S; Danos O; Retzel E; Tiollais P; Haase A; Wain-Hobson S
We have determined the complete 9202 nucleotide sequence of the visna lentivirus. The deduced genetic organization most closely resembles that of the AIDS retrovirus in that there is a novel central region separating pol and env. Moreover, there is a close phylogenetic relationship between the conserved reverse transc
Maddon PJ; Littman DR; Godfrey M; Maddon DE; Chess L; Axel R
The surface glycoproteins T4 and T8 define different functional subsets of T lymphocytes and may act as recognition molecules mediating appropriate interactions between the T cell and its target. Previously we employed gene transfer and subtractive hybridization to isolate a T8 cDNA; now we have isolated and sequenced
Yamada Y; Amagasaki T; Kamihira S; Kinoshita K; Ikeda S; Kusano M; Suzuyama J; Toriya K; Tomonaga Y; Ichimaru M
We report phenotypic and functional characterization of lymph node cells from 27 patients with T lymphoma from the Nagasaki district of Japan . Nagasaki is one of several areas where adult T-cell leukemia is endemic, and sera from 18 of 23 patients examined (78.3%) were positive for
Huygen K; Mascart-Lemone F; Cran S; Van de Perre P; Henrivaux P; De Ley M; Clumeck N
Serum interferon and in vitro production of alpha and gamma interferon by peripheral blood leucocytes were examined in 21 African patients with acquired immunodeficiency syndrome (AIDS) and in 15 African patients with AIDS-related complex. Interferon was detected in the serum of 44% of the patients with AIDS-related c
We have shown previously that antigens and also circulating immune complexes related to the primate retroviral envelope glycoprotein SiSV gp70 correlate with early mortality and survival of 56 patients with acute leukemias and chronic myelogenous leukemia in blast crisis. The prevalence and general distribution of the
Drescher B; Mohring R; Winkler J; Nyakatura G; Rosenthal S
We determined the nucleotide sequence of a molecularly cloned cDNA from the endogenous cat virus RD114. Comparison of the nucleotide sequence and the deduced amino acid sequence, respectively, with other known sequences of retroviruses revealed two conserved domains in the viral transmembrane protein, which we relate
Quantitation of acquired immune deficiency syndrome (AIDS)-related virus-bearing cells was analyzed by a newly developed plaque-forming assay. A chemically adherent HTLV-I-positive MT-4 cell monolayer was used as the cytolytic responder cells to the AIDS-virus infection. When AIDS-virus-infected cells (Molt-4/HTLV-III
Hino S; Yamaguchi K; Katamine S; Sugiyama H; Amagasaki T; Kinoshita K; Yoshida Y; Doi H; Tsuji Y; Miyamoto T
By screening sera obtained from 5015 pregnant women under the care of 9 gynecology/obstetrics departments of hospitals or clinics in Nagasaki City and its surrounding areas, 187 were found to be positive for antibody against adult T-cell leukemia-associated antigen (ATLA). The prevalence of seropositive pregnant women
Yamanouchi K; Kinoshita K; Moriuchi R; Katamine S; Amagasaki T; Ikeda S; Ichimaru M; Miyamoto T; Hino S
To obtain experimental support for possible milk-borne infection of human T-cell leukemia virus type-I (HTLV-I), short-term-cultured viral antigen-positive lymphocytes obtained from peripheral blood of adult T-cell leukemia lymphoma complex (ATLL) patients were inoculated into the oral cavity of two adult common marmo
The growing numbers of patients with the acquired immune deficiency syndrome (AIDS) in England had led to the development of a counselling service for patients, their sexual partners, contacts, and others. The nature of the counselling is described with reference to the primary qualitative issues arising from diagnosi
Int J Cancer. 1985 Aug 15;36(2):191-8. Unique Identifier : AIDSLINE MED/85260135
Sinangil F; Harada S; Purtilo DT; Volsky DJ
Adult T-cell leukemia virus is the member of a human type-C retrovirus family (HTLV) found to be associated with adult T-cell leukemia (ATL) in Japan . In our study, HTLV was isolated from the MT-2 cell line, purified on sucrose gradient and labelled with fluorescein-isothiocyanate (
J Cancer Res Clin Oncol. 1985;110(1):82-4. Unique Identifier : AIDSLINE MED/85261551
Akagi T; Ohtsuki Y; Takahashi K; Takeda I; Oka T; Miyoshi I
Human adult peripheral blood lymphocytes were successfully immortalized by co-cultivation with irradiated autologous and homologous T-cell lines harbouring human T-cell leukaemia virus-I (HTLV-I). The efficiency of transformation was the same in both cases. The participation of alloantigen stimulation in co-cultivatio
Markedly reduced ecto-5 -nucleotidase activity was found in peripheral blood lymphocytes from 27 out of 30 homosexual men with the acquired immune deficiency syndrome (AIDS) in association with Kaposi s sarcoma (AIDS-KS; 2.67 +/- 1.70 U/10(6) cells; n = 13), opportunistic infections (AIDS-OI; 9.29 +/- 7.32; n = 7), or
In the present study, a simple solid-phase radioimmunoassay was developed to determine detergent-extracted human leukemia-associated cell membrane antigens. In the assay, 96-well microtiter plates are coated with human leukemia cell membrane antigens containing a T cell leukemia or a non-T cell leukemia antigen in the
Takeuchi K; Kobayashi N; Nam SH; Yamamoto N; Hatanaka M
A 2.3 kb cDNA was cloned from human T-cell leukaemia virus [HTLV(MT-2)] virion RNA using a vector system, as plasmid pHTLV 707. The restriction endonuclease map of pHTLV 707 revealed that the insert contained the 5 half of the env gene and a portion of the pX region of HTLV, corresponding to the subgenomic RNA derive
We determined the complete nucleotide sequence of the intracisternal A-particle gene, IAP-H18, cloned from the normal Syrian hamster liver DNA. IAP-H18 was 7,951 base pairs in length with two identical long terminal repeats of 376 base pairs at both ends. On the coding strand, imperfect open reading frames correspondi
Casey JM; Kim Y; Andersen PR; Watson KF; Fox JL; Devare SG
The major internal structural protein of human T-cell lymphotropic virus type III (HTLV-III), a virus etiologically implicated in acquired immunodeficiency syndrome (AIDS), was purified to homogeneity. This 24,000-molecular-weight protein (p24) was shown to lack immunologic cross-reacting antigenic determinants shared
The 3 -terminal regions of the human T-cell leukemia virus I (HTLV-I) and HTLV-II genomes encode a novel gene product. We showed that expression of this region fused to the beta-galactosidase gene in bacteria produces a protein recognized by adult T-cell leukemia-lymphoma patient sera. Rabbit antibodies raised against
Cell lines established directly from adult T-cell leukemia-lymphoma patients or immortalized by human T-cell leukemia virus type I (HTLV-I) in vitro that do not produce complete HTLV virions were characterized both for the content of viral proteins and for the presence of trans-acting factors activating gene expressio
In January 1982, the Centers for Disease Control began a prospective study of unexplained generalized lymphadenopathy syndrome in 78 homosexual or bisexual men. As of Aug 1, 1984, the median durations of lymphadenopathy and enrollment were 29.5 months and 20 months, respectively. Antibodies to human T-cell lymphotropi
JAMA. 1985 Aug 23-30;254(8):1064-6. Unique Identifier : AIDSLINE MED/85265182
Dienstag JL; Werner BG; McLane MF; Snydman DR; Grady GF; Craven DE; Crumpacker CS; Polk BF; Platt R; Allan J; et al
A proportion of the plasma for the triply inactivated, plasma-derived hepatitis B vaccine produced in the United States is obtained from homosexual men. Because homosexual men are a high-risk group for the acquired immunodeficiency syndrome (AIDS), concern has emerged that the vaccine
From the mortality statistics on malignant lymphomas in Japan and nationwide studies on T- and B-cell malignancies, the number of deaths from adult T-cell leukemia/lymphoma (ATL) in adults older than 20 years in the Kyushu district was estimated at 339 or more per year in 1978-82. T
Three isolates of human acquired immunodeficiency syndrome (AIDS) virus (lymphadenopathy-associated virus, human T cell lymphotropic virus strain III, acquired immunodeficiency syndrome-associated retrovirus) were compared with simian AIDS virus by thin section transmission electron microscopy. Simian AIDS virus was f
Fisher AG; Collalti E; Ratner L; Gallo RC; Wong-Staal F
Acquired immune deficiency syndrome (AIDS) is an epidemic immunosuppressive disease characteristically associated with a depletion of T lymphocytes of the helper/inducer phenotype. Numerous converging lines of research have implicated a human T-cell lymphotropic retrovirus, HTLV-III, in the pathogenesis of AIDS. Recen
Ratner L; Josephs SF; Jarrett R; Reitz MS Jr; Wong-Staal F
Three c-sis cDNA clones were obtained from polyadenylated RNA of a human T-cell lymphotropic virus (HTLV) type I transformed cell line. Two clones, designated pSM-1 and pSM-2, have cDNA inserts of 2498 and 2509 base pairs (bp), respectively, excluding the sizes of the guanylate tails, and the polyadenylate tracts. The
Proc Natl Acad Sci U S A. 1985 Jul;82(14):4813-7. Unique Identifier : AIDSLINE MED/85270417
Hahn BH; Gonda MA; Shaw GM; Popovic M; Hoxie JA; Gallo RC; Wong-Staal F
Converging lines of research have linked human T-cell lymphotropic virus type III (HTLV-III) to the pathogenesis of the acquired immune deficiency syndrome. A characteristic feature of this virus is its genomic heterogeneity, which occurs to varying degrees in different viral isolates. To define further the nature and
Proc Natl Acad Sci U S A. 1985 Aug;82(15):4934-8. Unique Identifier : AIDSLINE MED/85270441
Seto B; Gerety RJ
A glycoprotein was isolated and purified to homogeneity from the serum of a patient with chronic non-A, non-B hepatitis. NaDodSO4/PAGE of the glycoprotein revealed a single major band at Mr approximately 77,000. Antibodies to this glycoprotein were shown to possess the following immunoreactivity: (i) they reacted by r
Proc Natl Acad Sci U S A. 1985 Aug;82(15):5199-202. Unique Identifier : AIDSLINE MED/85270492
di Marzo Veronese F; Sarngadharan MG; Rahman R; Markham PD; Popovic M; Bodner AJ; Gallo RC
Four mouse hybridomas secreting monoclonal antibodies specific for p24, the major core antigen of the human T-cell leukemia virus type III (HTLV-III), have been developed, and their specificities have been partially characterized. These antibodies specifically recognized p24 of HTLV-III in extracts of HTLV-III and in
Proc Natl Acad Sci U S A. 1985 Aug;82(16):5295-9. Unique Identifier : AIDSLINE MED/85270511
King CR; Giese NA; Robbins KC; Aaronson SA
The polypeptide sequence of the v-sis transforming gene product of simian sarcoma virus (SSV) can be divided into four regions that are likely to represent structural domains of the protein. Mutations were generated in the SSV nucleotide sequence to assay the extent or function of each of these regions. The results in
Acquired immunodeficiency syndrome (AIDS) and AIDS-related complex (ARC) are thought to be caused by human T-cell leukemia/lymphotropic virus type III (HTLV-III). Since the fall of 1982, independent isolates of HTLV-III have been obtained in this laboratory, in collaboration with several clinical groups, from 101 AIDS
Proc Natl Acad Sci U S A. 1985 Aug;82(16):5535-9. Unique Identifier : AIDSLINE MED/85270557
Kaminsky LS; McHugh T; Stites D; Volberding P; Henle G; Henle W; Levy JA
A rapid, sensitive indirect immunofluorescence assay has been developed for detection of antibodies to the acquired immune deficiency syndrome (AIDS)-associated retrovirus (ARV). The human T-cell line HUT-78 was chronically infected with ARV-2 and used to detect antibodies to virus-specific cytoplasmic antigens. Becau
252 monkeys kept at 4 different Swedish universities and laboratories for experimentation were screened for antibodies to HTLV I associated antigens by means of a sensitive membrane antigen enzyme immunoassay (MA-ELISA). 17/185 Macaca fascicularis, 1/56 M. mulatta, 0/1 Cercopithecus aetiops and 0/10 Saimirii squiureus
A lymphotropic virus HTLV-III/LAV was recently identified as the etiologic agent of the acquired immune deficiency syndrome (AIDS). In a study of concomitant hepatitis B infections in patients with AIDS or the AIDS-related complex, DNA sequences of hepatitis B virus (HBV) were found in fresh and cultured lymphocytes f
Science. 1985 Aug 9;229(4713):563-6. Unique Identifier : AIDSLINE MED/85272556
Harada S; Koyanagi Y; Yamamoto N
The human T-cell lines MT-2 and MT-4 carry the human T-cell leukemia virus type I (HTLV-I). When MT-2 and MT-4 were infected with HTLV-III, the probable etiologic agent of the acquired immune deficiency syndrome (AIDS), rapid cytopathogenic effects and cytotoxicity were observed that made it possible to titrate the bi
Science. 1985 Aug 16;229(4714):675-9. Unique Identifier : AIDSLINE MED/85272568
Felber BK; Paskalis H; Kleinman-Ewing C; Wong-Staal F; Pavlakis GN
Expression of the pX protein of human T-cell leukemia virus type I (HTLV-I) in animal cells demonstrates that this protein is a specific transcriptional activator of the long terminal repeats (LTR) of HTLV-I. Several other promoters are not affected by pX. No lymphocyte-specific factors are required for this activatio
The DNA genomes of human T-lymphotropic virus type III (HTLV-III) isolated from 18 individuals with AIDS or who were at risk for AIDS were evaluated for evidence of variation. Although all of the 18 viral DNA s hybridized throughout their entire genomes to a full-length cloned probe of the original HTLV-III isolate, e
S Afr Med J. 1985 Aug 3;68(3):139-43. Unique Identifier : AIDSLINE MED/85272877
Spracklen FH; Whittaker RG; Becker WB; Becker ML; Holmes CM; Potter PC
We report a case of acquired immune deficiency syndrome (AIDS) and one of AIDS-related complex presenting in Cape Town. The first patient was probably infected in the USA. In turn he infected the second patient by regular homosexual contact. Human T-cell lymphotropic virus type III (HTLV-III) was cultured, we believe
S Afr Med J. 1985 Aug 3;68(3):144-7. Unique Identifier : AIDSLINE MED/85272878
Becker ML; Spracklen FH; Becker WB
A virus similar to the lymphadenopathy-associated virus or human T-lymphotropic virus type III, which has been described in association with the acquired immune deficiency syndrome (AIDS) by several laboratories elsewhere in the world, was isolated from a Cape Town patient with lymphadenopathy and acquired immune defi
Chorba TL; Jason JM; Ramsey RB; Lechner K; Pabinger-Fasching I; Kalyanaraman VS; McDougal JS; Cabradilla CD; Tregillus LC; Lawrence DN; et al
Serum samples from 85 Austrian hemophilia patients treated with lyophilized factor concentrates prepared from U.S. plasma sources, 24 hemophilia patients from Georgia on a home therapy program with factor concentrates, and 10 U.S. hemophilia patients with acquired immunodeficiency
Trans Ophthalmol Soc U K. 1985;104 ( Pt 3):243-7. Unique Identifier : AIDSLINE MED/85273788
Sarkies NJ; Blach RK
New therapies and diseases causing immunosuppression have provoked new and devastating ocular diseases. The possible reasons for the vulnerability of the retina to opportunistic infections are discussed. The clinical patterns of disease caused by common opportunistic agents are described, and current treatment availab
Sandstrom EG; Schooley RT; Ho DD; Byington R; Sarngadharan MG; MacLane ME; Essex M; Gallo RC; Hirsch MS
Seropositivity to human T-cell lymphotrophic virus-III (HTLV-III) can have profound implications for the individual in whom it is detected. Simple and reliable tests are needed to confirm positivity by screening assays. In this study, detection of human antibodies by indirect immunofluorescence (IFA) on acetone-fixed
Since 2% of the cases of Acquired Immune Deficiency Syndrome (AIDS) have been attributed to transfusions of blood and blood products, licensed tests to detect antibody to the human T-lymphotropic virus type III (anti-HTLV-III) have been put into practice to reduce the risk of transfusion associated AIDS. Two commercia
Lange Wantzin G; Saxinger WC; Weismann K; Gallo RC
Sera from 119 patients attending a venereal disease clinic in Copenhagen during May 1983 were screened for antibodies to the newly characterized and isolated retrovirus HTLV-III. Ten out of 45 (22%) homosexual patients and two out of 74 (2.7%) heterosexual patients were found to have antibodies against HTLV-III. The h
Am J Ophthalmol. 1985 Aug 15;100(2):230-8. Unique Identifier : AIDSLINE MED/85276541
Kestelyn P; Van de Perre P; Rouvroy D; Lepage P; Bogaerts J; Nzaramba D; Clumeck N
A prospective study of ophthalmologic findings in 20 African patients with the acquired immunodeficiency syndrome (Group 1) and nine patients with acquired immune deficiency syndrome related complex (Group 2) disclosed that 11 patients in Group 1 and two patients in Group 2 had ocular involvement. Cotton-wool spots, R
Ann Intern Med. 1985 Sep;103(3):377-80. Unique Identifier : AIDSLINE MED/85277665
Felsenstein D; D'Amico DJ; Hirsch MS; Neumeyer DA; Cederberg DM; de Miranda P; Schooley RT
Cytomegalovirus infections can cause significant morbidity and mortality in immunosuppressed patients, and present antiviral agents have had little efficacy against these infections. We describe the use of an acyclic nucleoside 9-[2-hydroxy-1-(hydroxymethyl) ethoxy methyl]guanine (BW B759U), in the treatment of two pa
Ann Intern Med. 1985 Sep;103(3):402-3. Unique Identifier : AIDSLINE MED/85277672
Since the first case definition of the acquired immunodeficiency syndrome was published in 1982, minor revisions have been made in the list of diseases used as indicators of underlying cellular immunodeficiency, and, more recently, the human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV)
Palmer E; Sporborg C; Harrison A; Martin ML; Feorino P
Lymphocytes infected with human T-lymphotropic virus type III/lymphadenopathy-associated virus were examined by thin-section and immunoelectron microscopy, with horseradish peroxidase as an electron-dense marker. There was no evidence of an intracytoplasmic virion precursor, but viral antigen accumulated at the plasma
Within 10 minutes after tritium-labeled adult T-cell leukemia-associated virus (ATLV) inoculation, silver grains were found over human lymphocytes. At the time of entry of ATLV, the viral envelope was observed to fuse with the cell membrane.
A 30-year-old bisexual male prisoner with a history of intravenous drug abuse manifested encephalitis. Adenovirus type 2 was isolated from brain tissue obtained by a biopsy and there was a concurrent fourfold rise in the antibody titer. In addition, an initial negative result from a slide test for infectious mononucle
Cancer Res. 1985 Sep;45(9 Suppl):4568s-4573s. Unique Identifier : AIDSLINE MED/85254472
Papas TS; Samuel KP; Kan NC; Ascione R; Wong-Staal F; Lautenberger JA
The oncogenes coding for the Harvey murine sarcoma virus p21ras protein as well as those coding for myc, myb, and mht products were fused to the amino-terminal portion of the bacteriophage lambda cII gene on the expression vector pJL6. In addition two regions of the gene for the human T-cell leukemia virus subgroup I
Cancer Res. 1985 Sep;45(9 Suppl):4605s-4608s. Unique Identifier : AIDSLINE MED/85254481
Ginzburg HM; Weiss SH; MacDonald MG; Hubbard RL
The Centers for Disease Control hierarchical classification of those at risk for acquired immunodeficiency syndrome (AIDS) underestimates the number of cases in which illicit drug use may play a role in the exposure to human T-cell leukemia virus type III. The immunosuppressive effects of nitrite inhalants are not suf
Cancer Res. 1985 Sep;45(9 Suppl):4630s-4632s. Unique Identifier : AIDSLINE MED/85254489
Larouze B; Schaffar-Deshayes L; Blesonski S; Gaudebout C; Afoutou JM; Couillin P; Da Graca Porto M; Diakhate L; Frelut ML; Jeddi M; et al
Using a radioimmunoassay to detect HTLV-I protein antibodies of molecular weight 24,000, we screened populations from Algeria (140 subjects), Tunisia (442), Mali (69), Senega
Cancer Res. 1985 Sep;45(9 Suppl):4644s-4645s. Unique Identifier : AIDSLINE MED/85254492
Takatsuki K; Yamaguchi K; Kawano F; Hattori T; Nishimura H; Tsuda H; Sanada I; Nakada K; Itai Y
Adult T-cell leukemia-lymphoma (ATL) is a unique T-cell cancer first described in Japan . We estimate that more than 200 patients a year have been detected in Kyushu. The surface phenotype of ATL cells characterized by monoclonal antibodies is T3+, T4+, T8-, T11+, and Tac+. In all ca
Cancer Res. 1985 Sep;45(9 Suppl):4691s-4693s. Unique Identifier : AIDSLINE MED/85254505
Hunsmann G
Vaccines prepared from purified viral envelope complexes are effective against certain animal model tumors induced by exogenous retroviruses. Related viruses have recently been isolated from humans and obviously cause adult T-cell leukemia and the acquired immunodeficiency syndrome. Knowledge accumulated in experiment
The devastating orofacial gangrenous disease known as cancrum oris (noma) is still commonly seen in underprivileged Nigerian children. These children are usually victims of such stressors as chronic malnutrition, numerous endemic communicable diseases and severe adverse physical conditions which may lead to depletion
Fifteen haemophiliac patients acquired antibodies to human T-lymphotropic virus type III during 1984. One batch of factor VIII concentrate given to all these patients is presumed to be the cause of the seroconversion. A further eighteen patients who received the same batch did not seroconvert and one other patient bec
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