Successful chemotherapy with deoxycoformycin in adult T-cell lymphoma-leukaemia. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Successful chemotherapy with deoxycoformycin in adult T-cell lymphoma-leukaemia.

Br J Haematol. 1984 Dec;58(4):723-7. Unique Identifier : AIDSLINE MED/85097662
Daenen S; Rojer RA; Smit JW; Halie MR; Nieweg HO

Abstract: A patient from the Caribbean area with active T-cell lymphoma-leukaemia was primarily treated with deoxycoformycin (DCF), 5 mg/m2 i.v. on 3 consecutive days, followed by 5 mg/m2 i.v. weekly. A complete remission was attained and maintained during several weeks with DCF. A single consolidation course with other cytostatics was then given. The patient continues in complete remission without further therapy, 24 months after diagnosis, 17 months after the last cytostatic drugs. T-cell lymphoma-leukaemia has a bad prognosis with conventional anti-lymphoma therapy but was exquisitely sensitive to DCF in this patient.
Keywords: Adult Antineoplastic Agents/*THERAPEUTIC USE Case Report Coformycin/ANALOGS & DERIVATIVES/ADMINISTRATION & DOSAGE/ *THERAPEUTIC USE Drug Administration Schedule Female Human HTLV-BLV Viruses Leukemia/*DRUG THERAPY Lymphoma/*DRUG THERAPY Retroviridae Infections/*DRUG THERAPY Ribonucleosides/*THERAPEUTIC USE T-Lymphocytes JOURNAL ARTICLE

KWDadultantineoplasticagents/KWDtherapeuticusecasereportcoformycin/analogs&derivatives/administration&dosage/KWDtherapeuticusedrugadministrationschedulefemalehumanhtlv-blvvirusesleukemia/KWDdrugtherapylymphoma/KWDdrugtherapyretroviridaeinfections/KWDdrugtherapyribonucleosides/KWDtherapeuticuset-lymphocytesjournalarticle
850530
M8550094

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