Electron microscopic study of cell lines established from adult T-cell leukemia--coexistence of adult T-cell leukemia virus and Epstein-Barr virus. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Electron microscopic study of cell lines established from adult T-cell leukemia--coexistence of adult T-cell leukemia virus and Epstein-Barr virus.

Jpn J Clin Oncol. 1984 Dec;14(4):585-93. Unique Identifier : AIDSLINE MED/85108590
Hirose Y; Shimizu S; Takiguchi T; Sugai S; Konda S

Abstract: Six cell lines established from five patients with adult T-cell leukemia (ATL) were studied by electron microscopy. From one patient two cell lines were established, an interleukin 2-dependent line and a nondependent line. The interleukin 2-dependent T-cell line had only ATL virus (ATLV) particles. The interleukin 2-nondependent B-cell line had both ATLV particles and Epstein-Barr virus (EBV) particles. In two other B-cell lines and one undetermined cell line, both ATLV particles and EBV particles were seen. In one B-cell line only a few EBV particles were seen. These findings suggest that (1) interleukin 2 is necessary for the growth of leukemic T-cells from ATL tissue samples, and (2) ATLV can infect not only T-cells but also B-cells.
Keywords: Adult Antigens, Neoplasm/ANALYSIS Cell Line Female Herpesvirus 4, Human/*ULTRASTRUCTURE Human HTLV-BLV Viruses/*ULTRASTRUCTURE Leukemia/*MICROBIOLOGY/PATHOLOGY Male Microscopy, Electron Middle Age T-Lymphocytes JOURNAL ARTICLE

KWDadultantigens,neoplasm/analysiscelllinefemaleherpesvirus4,human/KWDultrastructurehumanhtlv-blvviruses/KWDultrastructureleukemia/KWDmicrobiology/pathologymalemicroscopy,electronmiddleaget-lymphocytesjournalarticle
850530
M8550089

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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