Ultrastructural study of type C virus particles in phytohemagglutinin-stimulated lymphocytes from healthy adults seropositive to adult T-cell leukemia-associated antigens. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Ultrastructural study of type C virus particles in phytohemagglutinin-stimulated lymphocytes from healthy adults seropositive to adult T-cell leukemia-associated antigens.

Acta Pathol Jpn. 1984 Nov;34(6):1277-83. Unique Identifier : AIDSLINE MED/85118330
Ohtsuki Y; Miyoshi I; Taguchi H; Takahashi K; Akagi T

Abstract: PHA-stimulated peripheral lymphocytes from six healthy adults consisting of four family members of an adult T-cell leukemia (ATL) patient and two blood bank donors, seropositive to ATL-associated antigens (ATLA), were all positive for the expression of ATLA and ATL-associated virus (ATLV). These results revealed that anti-ATLA-positive persons were healthy carriers of ATLV and that the numbers of ATLV observed in each culture were more proportional to the percentage of ATLA-positive lymphocytes than anti-ATLA titers of each person. Virus particles detected were C-type in morphology, and essentially similar to those observed in MT-2 and other ATL-related cells, but rather uniform in size, mostly 120-130 nm in diameter. Furthermore, it is of interest that tubuloreticular structures and striated fusiform structures, which were found in fresh or short term cultured ATL cells, were observed in some cultures of lymphocytes from anti-ATLA-positive healthy persons.
Keywords: Adolescence Adult Aged Cells, Cultured Female Fluorescent Antibody Technique Human HTLV-BLV Viruses/*IMMUNOLOGY Lymphocyte Transformation Lymphocytes/IMMUNOLOGY/*MICROBIOLOGY/ULTRASTRUCTURE Microscopy, Electron Middle Age Phytohemagglutinins Reference Values Retroviridae/*ULTRASTRUCTURE Support, Non-U.S. Gov't JOURNAL ARTICLE

KWDadolescenceadultagedcells,culturedfemalefluorescentantibodytechniquehumanhtlv-blvviruses/KWDimmunologylymphocytetransformationlymphocytes/immunology/KWDmicrobiology/ultrastructuremicroscopy,electronmiddleagephytohemagglutininsreferencevaluesretroviridae/KWDultrastructuresupport,non-uKWDsKWDgov'tjournalarticle
850530
M8550084

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1985. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1985. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .