[Toxoplasmosis encephalitis in patients with AIDS] NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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[Toxoplasmosis encephalitis in patients with AIDS]

Dtsch Med Wochenschr. 1985 Jan 18;110(3):83-7. Unique Identifier : AIDSLINE MED/85100955
Enzensberger W; Helm EB; Hopp G; Stille W; Fischer PA

Abstract: Toxoplasmosis encephalitis developed in three male homosexuals with AIDS. Clinical symptoms of encephalitis began with a nonspecific organic mental syndrome. In two cases there developed late focal symptoms. There were light to moderately severe generalized EEG changes with additional focal signs. CSF findings and toxoplasmosis titres were not diagnostically altered. Computed tomography demonstrated multiple areas of decreased density in cortex and cerebellum. Administration of pyrimethamine and sulfamethoxydiazine to the three patients brought about clinical improvement within a few days and regression of abnormal CT changes within a few weeks of onset of treatment. One patient died after an encephalitis recurrence: autopsy demonstrated toxoplasma pseudocysts in immediate proximity to small necrotic foci in the brain. The possibility of toxoplasma encephalitis should be considered in AIDS patients who develop an organic mental syndrome. Often the diagnosis can only be made after response to a trial of toxoplasmosis treatment.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Acyclovir/THERAPEUTIC USE Candidiasis, Oral/COMPLICATIONS/DRUG THERAPY Electroencephalography Encephalitis/*COMPLICATIONS/RADIOGRAPHY English Abstract Homosexuality Human Ketoconazole/THERAPEUTIC USE Male Tomography, X-Ray Computed Toxoplasmosis/*COMPLICATIONS JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDcomplicationsacyclovir/therapeuticusecandidiasis,oral/complications/drugtherapyelectroencephalographyencephalitis/KWDcomplications/radiographyenglishabstracthomosexualityhumanketoconazole/therapeuticusemaletomography,x-raycomputedtoxoplasmosis/KWDcomplicationsjournalarticle
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M8550080

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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