Nucleotide sequence of the AIDS virus, LAV. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Nucleotide sequence of the AIDS virus, LAV.

Cell. 1985 Jan;40(1):9-17. Unique Identifier : AIDSLINE GENBANK/K02013
Wain-Hobson S; Sonigo P; Danos O; Cole S; Alizon M

Abstract: The complete 9193-nucleotide sequence of the probable causative agent of AIDS, lymphadenopathy-associated virus (LAV), has been determined. The deduced genetic structure is unique: it shows, in addition to the retroviral gag, pol, and env genes, two novel open reading frames we call Q and F. Remarkably, Q is located between pol and env and F is half-encoded by the U3 element of the LTR. These data place LAV apart from the previously characterized family of human T cell leukemia/lymphoma viruses.
Keywords: Acquired Immunodeficiency Syndrome/*MICROBIOLOGY Amino Acid Sequence Antigens, Viral/GENETICS Base Sequence Cloning, Molecular DNA, Viral/*GENETICS *Genes, Structural *Genes, Viral Human HTLV-BLV Viruses/*GENETICS Species Specificity Viral Envelope Proteins/GENETICS Viral Proteins/*GENETICS JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDmicrobiologyaminoacidsequenceantigens,viral/geneticsbasesequencecloning,moleculardna,viral/KWDgeneticsKWDgenes,structuralKWDgenes,viralhumanhtlv-blvviruses/KWDgeneticsspeciesspecificityviralenvelopeproteins/geneticsviralproteins/KWDgeneticsjournalarticle
850530
M8550043

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1985. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1985. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .