Nucleic acid structure and expression of the human AIDS/lymphadenopathy retrovirus. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Nucleic acid structure and expression of the human AIDS/lymphadenopathy retrovirus.

Nature. 1985 Feb 7-13;313(6002):450-8. Unique Identifier : AIDSLINE GENBANK/K02083
Muesing MA; Smith DH; Cabradilla CD; Benton CV; Lasky LA; Capon DJ

Abstract: The 9,213-nucleotide structure of the AIDS/lymphadenopathy virus has been determined from molecular clones representing the integrated provirus and viral RNA. The sequence reveals that the virus is highly polymorphic and lacks significant nucleotide homology with type C retroviruses characterized previously. Together with an analysis of the two major viral subgenomic RNAs, these studies establish the coding frames for the gag, pol and env genes and predict the expression of a novel gene at the 3' end of the genome unrelated to the X genes of HTLV-1 and -II.
Keywords: Acquired Immunodeficiency Syndrome/*MICROBIOLOGY Base Sequence DNA DNA, Recombinant *Genes, Viral Human HTLV-BLV Viruses/*GENETICS Nucleic Acid Hybridization *RNA, Viral Transcription, Genetic Translation, Genetic Viral Envelope Proteins/GENETICS Viral Proteins/GENETICS JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDmicrobiologybasesequencednadna,recombinantKWDgenes,viralhumanhtlv-blvviruses/KWDgeneticsnucleicacidhybridizationKWDrna,viraltranscription,genetictranslation,geneticviralenvelopeproteins/geneticsviralproteins/geneticsjournalarticle
850530
M8550026

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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