Identification of new gene products coded from X regions of human T-cell leukemia viruses. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Identification of new gene products coded from X regions of human T-cell leukemia viruses.

Proc Natl Acad Sci U S A. 1985 Jan;82(2):302-6. Unique Identifier : AIDSLINE MED/85113189
Shimotohno K; Miwa M; Slamon DJ; Chen IS; Hoshino H; Takano M; Fujino M; Sugimura T

Abstract: Antibodies were raised against oligopeptides deduced from the nucleotide sequence in the conserved region located between env and the 3' long terminal repeat in human T-cell leukemia virus type I (HTLV-I) and type II (HTLV-II) to detect a protein coded from this region in virus-infected cells. Two of these antibodies precipitated a protein of 41 kilo-daltons in HTLV-I-infected cell lines and a protein of 38 kilo-daltons in HTLV-II-infected cells. The protein in HTLV-I-infected cells was precipitated by plasma from patients with adult T-cell leukemia but not by plasma from a normal adult. These results indicate that these proteins were translated from new coding regions (X) present in HTLV-I and HTLV-II.
Keywords: Base Sequence Cell Line DNA, Viral/*ANALYSIS Electrophoresis, Polyacrylamide Gel Human HTLV-BLV Viruses/*GENETICS Immunosorbent Techniques Leukemia/GENETICS Molecular Weight Oligopeptides/IMMUNOLOGY Support, Non-U.S. Gov't T-Lymphocytes Viral Proteins/*ANALYSIS JOURNAL ARTICLE

KWDbasesequencecelllinedna,viral/KWDanalysiselectrophoresis,polyacrylamidegelhumanhtlv-blvviruses/KWDgeneticsimmunosorbenttechniquesleukemia/geneticsmolecularweightoligopeptides/immunologysupport,non-uKWDsKWDgov'tt-lymphocytesviralproteins/KWDanalysisjournalarticle
850530
M8550025

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1985. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1985. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .