Malignant lymphoma presenting as Kaposi's sarcoma in a homosexual man with the acquired immunodeficiency syndrome. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Malignant lymphoma presenting as Kaposi's sarcoma in a homosexual man with the acquired immunodeficiency syndrome.

Ann Intern Med. 1985 Mar;102(3):338-40. Unique Identifier : AIDSLINE MED/85120376
Lind SE; Gross PL; Andiman WA; Stone GC; Schooley RT; Harris NL

Abstract: A homosexual man had Kaposi's sarcoma of the skin and lymph nodes. After a brief response to interferon, the patient developed new skin lesions. Massive bleeding in the gastrointestinal tract prompted endoscopy, which showed tumor involvement of the stomach, believed to be Kaposi's sarcoma. At autopsy, a diffuse lymphoma was found involving the skin and gastrointestinal tract, forming collision tumors in regions that contained Kaposi's sarcoma. Lymphomatous tissue, but not uninvolved lymph node or spleen, contained Epstein-Barr virus DNA, as shown by DNA hybridization studies. Epstein-Barr virus may play a role in the development of lymphoma in immunosuppressed patients. Unusual manifestations of tumors, such as the massive gastrointestinal bleeding seen in this case, may indicate the development of a second neoplasm.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Case Report DNA, Viral/ANALYSIS Gastrointestinal Neoplasms/PATHOLOGY Herpesvirus 4, Human/GENETICS Homosexuality Human Lymphoma/*ETIOLOGY/PATHOLOGY Male Middle Age Neoplasms, Multiple Primary/*ETIOLOGY/PATHOLOGY Sarcoma, Kaposi's/*ETIOLOGY/PATHOLOGY Skin Neoplasms/PATHOLOGY Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDcomplicationscasereportdna,viral/analysisgastrointestinalneoplasms/pathologyherpesvirus4,human/geneticshomosexualityhumanlymphoma/KWDetiology/pathologymalemiddleageneoplasms,multipleprimary/KWDetiology/pathologysarcoma,kaposi's/KWDetiology/pathologyskinneoplasms/pathologysupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
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Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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