Acquired immunodeficiency syndrome in the child of a haemophiliac. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Acquired immunodeficiency syndrome in the child of a haemophiliac.

Lancet. 1985 Jan 19;1(8421):133-5. Unique Identifier : AIDSLINE MED/85109887
Ragni MV; Urbach AH; Kiernan S; Stambouli J; Cohen B; Rabin BS; Winkelstein A; Gartner JC; Zitelli BZ; Malatack JJ; et al

Abstract: Oral thrush developed during the second month of life in the 5-month-old son of a patient with haemophilia A. He did not feed well, and interstitial pneumonitis, lymphadenopathy, hepatosplenomegaly, and a cellular immune defect consistent with the acquired immunodeficiency syndrome (AIDS) followed. Both parents had signs of pre-AIDS during the year before their son's illness. Transmission presumably occurred in 3 steps: parenterally, via factor VIII concentrate in the haemophiliac; heterosexually, from the haemophiliac to his wife; and vertically, from mother to infant, or via close paternal-infant or maternal-infant contact. This first report of AIDS in the child of a haemophiliac supports the theory that AIDS is caused by an infectious agent. Concentrate-treated haemophiliacs may transmit this agent to their spouses or children, resulting in pre-AIDS or AIDS.
Keywords: Acquired Immunodeficiency Syndrome/*GENETICS/IMMUNOLOGY/ TRANSMISSION Adult Antibodies, Viral/ANALYSIS Case Report Child, Preschool Factor VIII/THERAPEUTIC USE Female Hemophilia/*GENETICS/IMMUNOLOGY/THERAPY Human HTLV-BLV Viruses/IMMUNOLOGY Infant Male Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDgenetics/immunology/transmissionadultantibodies,viral/analysiscasereportchild,preschoolfactorviii/therapeuticusefemalehemophilia/KWDgenetics/immunology/therapyhumanhtlv-blvviruses/immunologyinfantmalesupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
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Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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