We report a case in which Cryptosporidium oocysts were detected during routine auramine screening of a sputum specimen for acid-fast bacilli. The patient was a 28-year-old male with acquired immune deficiency syndrome and intestinal cryptosporidiosis. Microbiology laboratory workers should be alert to the possibility
Cooper DA; Wodak A; Marriot DJ; Harkness JL; Ralston M; Hill A; Penny R
Cryptosporidiosis was found in a patient with the acquired immune deficiency syndrome. The microbiological and morphological features of this newly recognized opportunistic infection are distinctive and diagnostic.
Lazzarin A; Galli M; Moroni M; Cultraro D; Negri C; Parravicini C; Ragni MC; Fiorenza AM; Nervetti G; Zanussi C
Persistent unexplained lymphadenopathy with intermittent fever, weight loss, night sweats and malaise was observed in the period from March 1983 to April 1984 in 66 intravenous drug addicts living in Milan. A high percent of these subjects showed cellular immunity alterations, with significant decrease of total lympho
Cutaneous T-cell lymphomas define a spectrum of disorders associated with T-lymphocytic proliferation with clinical manifestations occurring in the skin during the course of the disease. This review has dealt with two rather uncommon disorders, namely mycosis fungoides and Sezary syndrome which are indolent malignant
A thorough search was made of United States Federal Government publications in an effort to uncover government interest and action on homosexuality in the United States. No references were found prior to 1920 to government publications that refer to homosexuality. Since that time there
Ann Neurol. 1984 Dec;16(6):668-72. Unique Identifier : AIDSLINE MED/85120703
Ezrin-Waters C; Klein M; Deck J; Lang AE
In an elderly woman, lymphoma involved the central nervous system and unusual nonlymphoreticular sites. Cerebrospinal fluid cell surface marker studies revealed a clone of malignant B cells. Studies of peripheral blood demonstrated a systemic disturbance of immune regulation similar to Epstein-Barr virus infections an
A patient from the Caribbean area with active T-cell lymphoma-leukaemia was primarily treated with deoxycoformycin (DCF), 5 mg/m2 i.v. on 3 consecutive days, followed by 5 mg/m2 i.v. weekly. A complete remission was attained and maintained during several weeks with DCF. A single consolidation course with other cytosta
Lazzarin A; Galli M; Introna M; Negri C; Mantovani A; Mella L; Ferrante P; Parravicini C; Trombini M; Aiuti F; et al
Persistent unexplained lymphadenopathy (LAS) with intermittent fever, weight loss, night sweats and malaise was observed from March to October 1983 in 16 of 133 intravenous drug addicts who had been followed for at least two years in a Center for Drug Addicts Assistance in Milan, Italy
Hirose Y; Shimizu S; Takiguchi T; Sugai S; Konda S
Six cell lines established from five patients with adult T-cell leukemia (ATL) were studied by electron microscopy. From one patient two cell lines were established, an interleukin 2-dependent line and a nondependent line. The interleukin 2-dependent T-cell line had only ATL virus (ATLV) particles. The interleukin 2-n
Hirose Y; Shimizu S; Takiguchi T; Sugai S; Tachibana J; Sawada M; Konda S; Haba T; Yamazaki Y
Ten cases of adult T-cell leukemia-lymphoma (ATL/L) in the Hokuriku district were studied. Five patients were born in endemic areas and later moved to Hokuriku. Five patients were from nonendemic areas, and have not lived in endemic areas. All of the five patients from nonendemic areas had antibody to the adult T-cell
We present a case of bilateral herpes simplex and cytomegalovirus retinitis and concurrent encephalitis following acyclovir therapy in a homosexual male with the acquired immune deficiency syndrome (AIDS). At autopsy, herpes simplex virus ant
Ohtsuki Y; Miyoshi I; Taguchi H; Takahashi K; Akagi T
PHA-stimulated peripheral lymphocytes from six healthy adults consisting of four family members of an adult T-cell leukemia (ATL) patient and two blood bank donors, seropositive to ATL-associated antigens (ATLA), were all positive for the expression of ATLA and ATL-associated virus (ATLV). These results revealed that
Acta Med Okayama. 1984 Dec;38(6):505-10. Unique Identifier : AIDSLINE MED/85118524
Ohtsuki Y; Akagi T; Takeda I; Miyoshi I
To search for lymphocyte marker antigens on the surface of human T-cell leukemia virus (HTLV), an immunoelectron microscopic study was performed on a HTLV-producing human T-cell line, MT-2, using monoclonal antibodies, such as anti-Leu-1, -Leu-2b, -Leu-3a, Leu-5, -Leu-10 and -HLA-DR and OKIal. The reactivity of each a
Cancer. 1985 Mar 1;55(5):1146-8. Unique Identifier : AIDSLINE MED/85098983
Garrett TJ; Lange M; Ashford A; Thomas L
Kaposi s sarcoma is a feature of the acquired immunodeficiency syndrome (AIDS) in male homosexuals and Haitians. In this report the authors describe six heterosexual intravenous drug users who developed Kaposi s sarcoma. They had other characteristics of AIDS including opportunistic infections (oral candidiasis, six p
Dtsch Med Wochenschr. 1985 Jan 18;110(3):83-7. Unique Identifier : AIDSLINE MED/85100955
Enzensberger W; Helm EB; Hopp G; Stille W; Fischer PA
Toxoplasmosis encephalitis developed in three male homosexuals with AIDS. Clinical symptoms of encephalitis began with a nonspecific organic mental syndrome. In two cases there developed late focal symptoms. There were light to moderately severe generalized EEG changes with additional focal signs. CSF findings and tox
Pindyck J; Waldman A; Zang E; Oleszko W; Lowy M; Bianco C
We studied whether volunteers giving blood to the Greater New York Blood Program (GNYBP) cooperated with procedures implementing public health recommendations intended to decrease the risk of acquired immunodeficiency syndrome (AIDS) transmission by blood transfusion. Predonation medical screening was expanded to excl
Thomsen HK; Jacobsen M; Gerstoft J; Malchow-Moller A
Three homosexual men with acquired immunodeficiency syndrome (AIDS) were referred to Hvidovre Hospital, Copenhagen, during 1981. Biopsies from lymph nodes (case 2), skin (case 1 and 3), oral mucosal membrane (case 1) and lung (case 3) revealed Kaposi Sarcoma (KS). Furthermore, KS was found at autopsy in several other
Am J Med. 1985 Feb;78(2):317-20. Unique Identifier : AIDSLINE MED/85119313
Abramson SB; Odajnyk CM; Grieco AJ; Weissmann G; Rosenstein E
Five male homosexuals, four of whom had Kaposi s sarcoma, presented with painful swelling of the lower extremity. The overlying skin was erythematous and exquisitely tender. Deep vein thrombosis was strongly suspected in all patients. Venography, however, revealed no evidence of venous occlusion. This condition, which
Modigliani R; Bories C; Le Charpentier Y; Salmeron M; Messing B; Galian A; Rambaud JC; Lavergne A; Cochand-Priollet B; Desportes I
Chronic diarrhoea is frequent in acquired immune deficiency syndrome (AIDS) but has been poorly investigated so far. We report four patients with AIDS in whom diarrhoea and malabsorption were outstanding features, and who underwent extensive digestive investigations. Diarrhoea was a presenting symptom in all subjects
The toxicity of recombinant Interleukin-2 ( IL-2 ) was studied in patients with acquired immunodeficiency syndrome (AIDS) or persistent lymphadenopathy syndrome (LAS). Increasing doses of the drug from 10(3) Units/m2 to 10(6) U/m2 were given as an intravenous bolus injec
The validity and reliability of gallium-67 (Ga-67) scanning for diagnosis and follow-up of Pneumocystis carinii pneumonia (PCP) were assessed in 34 patients thought to have pulmonary complications of acquired immunodeficiency syndrome (AIDS). Overall sensitivity was 94% and specificity 74%. Among patients with normal
Am J Med. 1985 Feb;78(2):203-10. Unique Identifier : AIDSLINE MED/85119298
Wheat LJ; Slama TG; Zeckel ML
This report describes the experience with disseminated histoplasmosis in seven of 15 patients with the acquired immune deficiency syndrome (AIDS) diagnosed in Indianapolis since 1981. Three were homosexual, two were intravenous drug addicts, one was the spouse of another patient with AIDS and disseminated histoplasmos
To provide a better understanding of the morphologic changes that take place in the intestine and colon in acquired immunodeficiency syndrome (AIDS), electron microscopy was performed on intestinal or colonic biopsy specimens obtained from 6 patients with AIDS and from 2 patients with AIDS-related lymphadenopathy synd
Patients with the acquired immunodeficiency syndrome (AIDS) exhibit a variety of disorders of cellular immunity, including a deficient ability to generate cytotoxic T cells and depressed levels of natural killer (NK) cell activity. Interleukin 2 (IL 2) in vitro can markedly augment these depressed immune functions. Be
JAMA. 1985 Feb 22;253(8):1140-5. Unique Identifier : AIDSLINE MED/85108350
Jason J; Hilgartner M; Holman RC; Dixon G; Spira TJ; Aledort L; Evatt B
Persons with hemophilia are at risk of the acquired immunodeficiency syndrome (AIDS), and clinically asymptomatic hemophiliacs have shown a high incidence of AIDS-like immune abnormalities, facts leading to speculation that many hemophiliacs have been exposed to the AIDS agent through their blood products. We therefor
The third member of the family of T cell leukemia viruses (HTLV III) has been proposed as the primary etiologic agent of the acquired immunodeficiency syndrome (AIDS). A high risk of AIDS has been reported among patients with hemophilia, particularly those with factor VIII deficiency who receive commercial clotting fa
In a first seroepidemiological study on the prevalence of the human T-lymphotropic retrovirus HTLV-III in West Germany , sera of 26 patients with acquired immunodeficiency syndrome (AIDS), 33 patients with lymphadenopathy syndrome (LAS) or AIDS related complex (ARC), and 113 homose
Wain-Hobson S; Sonigo P; Danos O; Cole S; Alizon M
The complete 9193-nucleotide sequence of the probable causative agent of AIDS, lymphadenopathy-associated virus (LAV), has been determined. The deduced genetic structure is unique: it shows, in addition to the retroviral gag, pol, and env genes, two novel open reading frames we call Q and F. Remarkably, Q is located b
Int J Cancer. 1985 Jan 15;35(1):65-72. Unique Identifier : AIDSLINE MED/85103943
Lennert K; Kikuchi M; Sato E; Suchi T; Stansfeld AG; Feller AC; Hansmann ML; Muller-Hermelink HK; Godde-Salz E
A total of 56 cases of malignant lymphoma presumed to be of peripheral T-cell origin were investigated with regard to histological and immunohistochemical features. The goal of the study was to determine whether virus-associated T-cell lymphomas can be morphologically or immunohistochemically distinguished from presum
Int J Cancer. 1985 Jan 15;35(1):81-5. Unique Identifier : AIDSLINE MED/85103945
Miyoshi I; Yoshimoto S; Kubonishi I; Fujishita M; Ohtsuki Y; Yamashita M; Yamato K; Hirose S; Taguchi H; Niiya K; et al
A rabbit lymphoid cell line (Ra-1) was established by co-cultivation with a human T-cell line (MT-2) carrying human T-cell leukemia virus (HTLV). The Ra-1 cell line is chromosomally male and is persistently infected with HTLV. Ra-1 cells, with or without mitomycin C treatment, were inoculated intravenously (i.v.) into
Leonard WJ; Depper JM; Kronke M; Robb RJ; Waldmann TA; Greene WC
The T-cell growth factor (TCGF) receptor on phytohemagglutinin-activated normal peripheral blood T-cells is characterized as a glycoprotein with an apparent Mr = 55,000 that contains N-linked and O-linked carbohydrate with only approximately 33,000 daltons of peptide structure (p33) as evaluated by sodium dodecyl sulf
Yodoi J; Teshigawara K; Nikaido T; Fukui K; Noma T; Honjo T; Takigawa M; Sasaki M; Minato N; Tsudo M; et al
A continuous cell line (YT cells) with inducible receptor for T cell growth factor (TCGF)/interleukin 2 (IL 2) was established from a 15-yr-old boy with acute lymphoblastic lymphoma and thymoma. YT cells were tetraploid, having 4q+ chromosomal markers, and proliferated continuously in vitro without conditioned medium
Shimizu K; Hirano T; Ishibashi K; Nakano N; Taga T; Sugamura K; Yamamura Y; Kishimoto T
Human peripheral T cells were transformed by human T cell leukemia virus (HTLV), and T cell lines producing BGDF (BCGF II) and BCDF were established. Among these cell lines, a cell line, TCL-Na1, secreted the highest level of both BGDF and BCDF, and the amount of BCDF secreted by TCL-Na1 cells was 900-fold more than t
McDougal JS; Cort SP; Kennedy MS; Cabridilla CD; Feorino PM; Francis DP; Hicks D; Kalyanaraman VS; Martin LS
Detection of replicating human retroviruses has relied upon rather cumbersome reverse transcriptase, immunofluorescence, or electron microscopic assays. We describe a new sandwich enzyme-linked immunoassay (ELISA) for detecting the human retrovirus, lymphadenopathy-associated virus (LAV), in supernates of LAV-infected
J Med Virol. 1985 Jan;15(1):57-63. Unique Identifier : AIDSLINE MED/85107137
Born M; von der Helm K; Wernicke D; Deinhardt F
Sera from German patients exhibiting symptoms compatible with the acquired immune deficiency syndrome (AIDS) or the lymphadenopathy syndrome (LAS) were assayed for antibodies against human T-cell lymphoma/leukemia virus (HTLV-I)-related antigens by enzyme immunoassay, indirect immunofluorescence, and radioimmunoprecip
The acquired immunodeficiency syndrome has been observed with increasing frequency in children with associated hemophilia, high-risk environmental backgrounds, and blood transfusions. AIDS should be considered in the differential diagnosis of childhood immunodeficiency, and it must be distinguished from congenital dis
Moore JL; Poiesz BJ; Zamkoff KW; Merl SA; Hanna S; Gazdar AF; Comis RL
Particular interest in human T lymphocyte lymphoma/leukemia virus (HTLV) derives from the close association of HTLV with several types of human mature T lymphocyte malignancies and the strong possibility that HTLV is the causative agent of this group of leukemias and lymphomas. This is the first report to show that HT
A total of 2048 serum samples from Germany were examined for antibodies to adult T-cell leukemia virus (ATLV) structural polypeptides with an enzyme-linked immuno sorbent assay (ELISA) and confirmative immuno precipitation. The origin of the sera samples was: 850 samples taken for
Viral infection is commonly observed after bone-marrow transplantation. We isolated adenovirus from 51 of 1051 patients undergoing marrow transplantation between 1976 and 1982. Of the 46 isolates available for typing, 13 (27.7 per cent) were of the closely related species 11, 34, or 35 (subgenus B). All 13 of the pati
The complete nucleotide sequence of two human T-cell leukaemia type III (HTLV-III) proviral DNAs each have four long open reading frames, the first two corresponding to the gag and pol genes. The fourth open reading frame encodes two functional polypeptides, a large precursor of the major envelope glycoprotein and a s
Nature. 1985 Feb 7-13;313(6002):450-8. Unique Identifier : AIDSLINE GENBANK/K02083
Muesing MA; Smith DH; Cabradilla CD; Benton CV; Lasky LA; Capon DJ
The 9,213-nucleotide structure of the AIDS/lymphadenopathy virus has been determined from molecular clones representing the integrated provirus and viral RNA. The sequence reveals that the virus is highly polymorphic and lacks significant nucleotide homology with type C retroviruses characterized previously. Together
Proc Natl Acad Sci U S A. 1985 Jan;82(2):302-6. Unique Identifier : AIDSLINE MED/85113189
Shimotohno K; Miwa M; Slamon DJ; Chen IS; Hoshino H; Takano M; Fujino M; Sugimura T
Antibodies were raised against oligopeptides deduced from the nucleotide sequence in the conserved region located between env and the 3 long terminal repeat in human T-cell leukemia virus type I (HTLV-I) and type II (HTLV-II) to detect a protein coded from this region in virus-infected cells. Two of these antibodies
Ann Intern Med. 1985 Mar;102(3):331-3. Unique Identifier : AIDSLINE MED/85120374
Zaloga GP; Chernow B; Eil C
Two patients with the acquired immunodeficiency syndrome and disseminated cytomegalovirus infection developed hypercalcemia associated with suppressed parathyroid gland activity. Neither patient had evidence of a malignant, endocrinologic, granulomatous, or drug-related cause for h
We studied a cohort of 45 homosexual men with the acquired immunodeficiency syndrome, 78 with persistent unexplained generalized lymphadenopathy, and 160 asymptomatic homosexual controls for serologic evidence of infection with human T-lymphotropic virus type III (HTLV-III). Study participants were recruited from a co
A homosexual man had Kaposi s sarcoma of the skin and lymph nodes. After a brief response to interferon, the patient developed new skin lesions. Massive bleeding in the gastrointestinal tract prompted endoscopy, which showed tumor involvement of the stomach, believed to be Kaposi s sarcoma. At autopsy, a diffuse lymph
Oral thrush developed during the second month of life in the 5-month-old son of a patient with haemophilia A. He did not feed well, and interstitial pneumonitis, lymphadenopathy, hepatosplenomegaly, and a cellular immune defect consistent with the acquired immunodeficiency synd
Lymphadenopathy associated virus is inactivated by heating at 56 degrees C for 30 min, and is not inactivated by 2 X 10(5) rad gamma irradiation or 5 X 10(3) J/m2 ultraviolet irradiation.
Lancet. 1985 Feb 9;1(8424):301-4. Unique Identifier : AIDSLINE MED/85110039
Valle SL; Saxinger C; Ranki A; Antonen J; Suni J; Lahdevirta J; Krohn K
In a prospective follow-up volunteer study lasting 4 to 16 months, 17 of 200 homosexual men living in Finland had antibodies to human T-lymphotrophic virus type III (HTLV-III). 1 man who initially had a low titre of HTLV-III antibod
Serum samples from African patients with Kaposi s sarcoma and acquired-immuno-deficiency-syndrome-related (AIDS-related) disorders and from normal subjects in Uganda and Zambia were tested for antibodies to the human T-lymphotropic retroviruses
This information is designed to support, not replace, the relationship that exists between you and your doctor.