Transfusion-associated acquired immune deficiency syndrome in infants. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Transfusion-associated acquired immune deficiency syndrome in infants.

J Pediatr. 1984 Nov;105(5):731-7. Unique Identifier : AIDSLINE MED/85057390
Church JA; Isaacs H

Abstract: Two preterm infant boys not known to be at risk developed clinical, laboratory, and pathologic features of acquired immune deficiency syndrome (AIDS) after receiving multiple blood transfusions in the neonatal period. Their clinical courses were characterized by failure to thrive, recurrent otitis media, hepatomegaly, and fatal interstitial pneumonia. Laboratory evaluation revealed progressive lymphopenia, reversed T helper/suppressor ratios, increased percentages of B-lymphocytes, decreased lymphoproliferative responses to mitogens, hyperimmunoglobulinemia, and high levels of circulating immune complexes. At postmortem examination thymic involution, lymphocyte depletion in spleen and lymph nodes, and micronodular mineralization in the central nervous system were seen. The findings were not specific for other known congenital immune deficiencies and were most indicative of AIDS. The lack of other risk factors suggests transmission of AIDS via blood transfusions in the neonatal period.
Keywords: Acquired Immunodeficiency Syndrome/*ETIOLOGY/IMMUNOLOGY/PATHOLOGY Antibody Formation Blood Transfusion/*ADVERSE EFFECTS Calcinosis/PATHOLOGY Case Report Child, Preschool Human Infant Lymph Nodes/ULTRASTRUCTURE Lymphocyte Transformation Lymphoid Tissue/PATHOLOGY Lymphopenia/IMMUNOLOGY Male Pneumonia/PATHOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDetiology/immunology/pathologyantibodyformationbloodtransfusion/KWDadverseeffectscalcinosis/pathologycasereportchild,preschoolhumaninfantlymphnodes/ultrastructurelymphocytetransformationlymphoidtissue/pathologylymphopenia/immunologymalepneumonia/pathologyjournalarticle
850330
M8530153

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