Use of interleukin-2 in patients with acquired immunodeficiency syndrome. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Use of interleukin-2 in patients with acquired immunodeficiency syndrome.

J Biol Response Mod. 1984 Oct;3(5):512-6. Unique Identifier : AIDSLINE MED/85057052
Lane HC; Siegel JP; Rook AH; Masur H; Gelmann EP; Quinnan GV; Fauci AS

Abstract: Twelve patients with acquired immunodeficiency syndrome were treated with a natural product, highly purified human interleukin-2. Doses ranged from 250 to 250,000 units. No clinical responses were seen. Minimal toxicity was noted and consisted of mild prolongation of partial thromboplastin time and proteinuria. Immunologic changes during the study included a decrease in the number of circulating T8 lymphocytes, increased skin test reactivity, and a decline in serum immunoglobulin levels.
Keywords: Acquired Immunodeficiency Syndrome/IMMUNOLOGY/*THERAPY Comparative Study Drug Evaluation Human Immunoglobulins/ANALYSIS Immunotherapy/ADVERSE EFFECTS Interleukin-2/*ADMINISTRATION & DOSAGE Skin Tests T-Lymphocytes/IMMUNOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/immunology/KWDtherapycomparativestudydrugevaluationhumanimmunoglobulins/analysisimmunotherapy/adverseeffectsinterleukin-2/KWDadministration&dosageskintestst-lymphocytes/immunologyjournalarticle
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M8530110

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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