Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.
Autologous mixed lymphocyte reaction in man. XIV. Deficiency of the autologous mixed lymphocyte reaction in acquired immune deficiency syndrome (AIDS) and AIDS related complex (ARC). In vitro effect of purified interleukin-1 and interleukin-2.
Clin Exp Immunol. 1984 Nov;58(2):395-401. Unique Identifier : AIDSLINE MED/85049674 Gupta S; Gillis S; Thornton M; Goldberg M
Abstract:
Peripheral blood mononuclear cells from male homosexuals with acquired immune deficiency syndrome (AIDS) and with AIDS related complex (ARC) were examined for the autologous mixed lymphocyte reaction (AMLR) between responder T and irradiated autologous non-T cells and in vitro influence of purified human interleukin-1 (IL-1) and -2 (IL-2) on the AMLR. The AMLR was significantly (P less than 0.001) deficient in both ARC and AIDS; the deficiency of the AMLR was of the similar magnitude in two groups when compared to asymptomatic homosexuals and healthy heterosexuals. In vitro addition of IL-2 enhanced the AMLR to the baseline levels of control subjects in most patients in ARC group (P less than 0.01) and in four of 15 patients in AIDS group (P less than 0.01). Addition of IL-1 to IL-2 containing cultures resulted in no further increase in the AMLR response over those with IL-2 alone. This study demonstrates deficiency of the AMLR in patients with ARC and AIDS that is corrected by purified IL-2 in the majority of cases with ARC but only a subset of patients with AIDS. The significance of these findings is discussed.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Cells, Cultured Comparative Study Human Interleukin-1/*IMMUNOLOGY Interleukin-2/*IMMUNOLOGY Leukocyte Count Lymphocyte Culture Test, Mixed Lymphocytes/*IMMUNOLOGY/METABOLISM Male Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. T-Lymphocytes/IMMUNOLOGY T-Lymphocytes, Cytotoxic/IMMUNOLOGY Thymidine/METABOLISM JOURNAL ARTICLE
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Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.
