T cell growth factors from adult T cell leukemia virus-transformed cell lines. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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T cell growth factors from adult T cell leukemia virus-transformed cell lines.

FEBS Lett. 1984 Nov 19;177(2):200-4. Unique Identifier : AIDSLINE MED/85051846
Okai Y; Oka T; Akagi T; Kurata S; Fujiyoshi N

Abstract: Some characteristics of T cell growth factors derived from adult T cell leukemia virus (ATLV)-transformed cell lines, MT 1 and MT 2 were analyzed. MT 1 cells release significant interleukin 2 (IL 2) activity into the culture medium, which showed the same elution pattern of gel filtration and isoelectric focusing of IL 2 from lectin-stimulated normal human lymphocytes. This activity was also detected in the cell extract of MT 1. In contrast, MT 2 cell line did not produce IL 2 activity, but non-IL 2 type growth factor was observed. The significance of these factors from MT cell lines is discussed from the viewpoint of 'autokine' in ATLV-transformed cells.
Keywords: Adult Animal Cell Line *Cell Transformation, Viral Concanavalin A DNA Replication Human HTLV-BLV Viruses/*IMMUNOLOGY Interleukin-2/*ISOLATION & PURIF Leukemia/*IMMUNOLOGY Lymphocyte Transformation Mice Mice, Inbred Strains T-Lymphocytes/IMMUNOLOGY JOURNAL ARTICLE

KWDadultanimalcelllineKWDcelltransformation,viralconcanavalinadnareplicationhumanhtlv-blvviruses/KWDimmunologyinterleukin-2/KWDisolation&purifleukemia/KWDimmunologylymphocytetransformationmicemice,inbredstrainst-lymphocytes/immunologyjournalarticle
850330
M8530069

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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