Identification of a potential protease-coding gene in the genomes of bovine leukemia and human T-cell leukemia viruses. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Identification of a potential protease-coding gene in the genomes of bovine leukemia and human T-cell leukemia viruses.

FEBS Lett. 1984 Dec 3;178(1):79-82. Unique Identifier : AIDSLINE MED/85051885
Sagata N; Yasunaga T; Ikawa Y

Abstract: The genomes of bovine leukemia and human T-cell leukemia viruses both contain an unidentified region between the gag and pol genes. These regions harbor an open reading frame that is in a different phase from the reading frames of the gag and pol genes. Based on the deduced amino acid sequences, we show here that they potentially encode a gag precursor-cleaving protease, which is known to be fused to the gag and pol products of avian and murine retroviruses, respectively. This finding raises the interesting question of the expression and evolution of retroviral genes.
Keywords: Amino Acid Sequence Base Sequence Comparative Study HTLV-BLV Viruses/ENZYMOLOGY/*GENETICS Leukemia Virus, Bovine/ENZYMOLOGY/*GENETICS Peptide Hydrolases/ANALYSIS/*GENETICS Retroviridae/*GENETICS Support, Non-U.S. Gov't JOURNAL ARTICLE

KWDaminoacidsequencebasesequencecomparativestudyhtlv-blvviruses/enzymology/KWDgeneticsleukemiavirus,bovine/enzymology/KWDgeneticspeptidehydrolases/analysis/KWDgeneticsretroviridae/KWDgeneticssupport,non-uKWDsKWDgov'tjournalarticle
850330
M8530068

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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