New York, N.Y. : New York Academy of Sciences, 1984 xiv, 622 p. : ill (Annals of the New York Academy of Sciences, ISSN 0077-8923 ; v. 437) Unique Identifier : AIDSLINE CAT/8500816
Aaronson SA; Lab. of Celular and Molecular Biology, Nat. Cancer Inst.,; Bethesda, MD 20205
Investigations of the genetic alterations that cause normal cells to become malignant have focused on a small set of cellular genes. Acute transforming retroviruses have substituted viral genes necessary for replication with these discrete segments of host genetic information. When incorporated within the retroviral g
A series of human/rodent hybrid somatic cell lines containing reduced complements of human chromosomes were analyzed as follows to determine the chromosomal location of cellular onc genes in human cells. The transforming gene (v-sis) of simian sarcoma virus (SSV) was subcloned in pBR322, and the human homolog (c-mos)
Concepts in Viral Pathogenesis. Notkins Al, Oldstone MBA, eds. New York, Springer-Verlag, pp. 279-87 1984. Unique Identifier : AIDSLINE ICDB/85605991
Sarin PS; Gallo RC; National Cancer Institute, Bethesda, MD 20205
This review first outlines the distinguishing characteristics of chronic and acute leukemia viruses, then proceeds to describe the recently isolated human T-cell leukemia-lymphoma virus (HTLV) under the following section headings: T-cell growth factor, HTLV isolation and transmission, HTLV epidemiology, mechanism of t
Cancer. 1984 Dec 15;54(12):2968-72. Unique Identifier : AIDSLINE MED/85048646
Risdall RJ; Brunning RD; Hernandez JI; Gordon DH
Histiocytic medullary reticulosis (HMR) was originally defined as a neoplastic disorder. Some cases reported as HMR have been characterized by a systemic proliferation of mature histiocytes showing hemophagocytosis, bone marrow necrosis, pancytopenia, hepatitis, and coagulopathy. Clinically, these patients have fever
Hersh EM; Mansell PW; Reuben JM; Rios A; Newell GR
Immunological, hematological, and biochemical studies were done at the time of referral in 135 homosexual subjects, 28 of whom were symptom free (SF), 74 of whom had the acquired immune deficiency syndrome (AIDS)-related symptom complex (ARC), and 33 of whom had AIDS with Kaposi s sarcoma, opportunistic infection, or
The exact nature of the immune defect in the acquired immune deficiency syndrome (AIDS) is not known. Most studies have focused on abnormal T-cell functions which occur in AIDS. Although polyclonal elevation of serum immunoglobulins is also consistently reported in AIDS, there have been no statistical studies measurin
A 37-year-old homosexual man suffering from AIDS (= Acquired Immune Deficiency Syndrome) is described. This man died from disseminated Kaposi-sarcomas about one year after establishing the diagnosis.
Two preterm infant boys not known to be at risk developed clinical, laboratory, and pathologic features of acquired immune deficiency syndrome (AIDS) after receiving multiple blood transfusions in the neonatal period. Their clinical courses were characterized by failure to thrive, recurrent otitis media, hepatomegaly,
The contribution of occupational and environmental exposures to the etiology of cancer is a topic of considerable scientific and public interest. If an occupational environmental exposure is associated with cancer in man, then both the exposure and the disease are preventable by appropriate protection. In order to enh
Neurologic syndromes in AIDS are of four types: infections, para-infections, neoplastic, and paraneoplastic. All levels of the neuraxis can be affected. Neurologic complications may be the initial symptom or the cause of death. Aggressive evaluation, including biopsy of cerebral lesions, is indicated because effective
Epidemiologic methods are designed to identify risk factors involved in production of a particular disease, even when the specific etiologic agent is unknown. However, a major problem currently presenting obstacles to research on the acquired immunodeficiency syndrome (AIDS) relates to classification; approaches are d
Recently, we and others have encountered a group of infants who developed AIDS. They were born from parents who belonged to identified risk factors for AIDS. The clinical and immunologic features were described. The existence of a pediatric form of AIDS transmitted other than by transfusion suggests the possibility of
Nearly three years after the first A.I.D.S. cases were detected in the United States , a lot of countries throughout the world have reported varied numbers of such cases. While several U.S. towns have to face up to an epidemic situation, the same phenomenon has not been observed yet in
AIDS is reported in a 14 year old hemophiliac B. This patient was treated on demand and used 800 F IX IU per kg B.W. and per year. He presented with severe opportunistic infection (Toxoplasmosis) and profound impairment of cellular immunity. He suffered of chronic active hepatitis and he was chronic HBs Ag carrier. A
Following an inquiry to determine what measures has been taken since january 1984 in French Blood Centers to avoid transmission of AIDS by blood, answers from 49 % of the centers, representing 75 % of the blood collection in France were analyzed. Due to the absence of a biological
Simonneau M; Regnier B; Vittecocq D; Saimot G; Lefort C; Matheron S; Elias A; Branger M; Becker AM; Hirsch-Marie F; et al
The study of 28 confirmed cases of AIDS shows that transfused patients use a large amount of hospital s blood products, especially platelets. For these patients, the average cost of transfusion is higher than that, for intensive care unit patient s. The use of irradiated products increases the cost (+ 35%). As there i
There is presently no evidence of AIDS transmission to laboratory workers. Because transmissible agent is suspected, precautions should be taken in laboratories. As a general rule, procedures appropriate for hepatitis B prevention are advised. These procedures concern blood collection, carrying, and processing. Measur
S Afr Med J. 1984 Nov 24;66(21):806-9. Unique Identifier : AIDSLINE MED/85066142
Ras GJ; Eftychis HA; Anderson R; van der Walt I
In addition to the well-documented abnormalities of cell-mediated immunity we have observed that both polymorphonuclear leucocytes (PMNLs) and mononuclear leucocytes (MNLs) from 3 patients with the acquired immunodeficiency syndrome (AIDS) showed markedly defective migratory responsiveness to leuko-attractants in vitr
Am J Trop Med Hyg. 1984 Nov;33(6):1060-4. Unique Identifier : AIDSLINE MED/85069984
Forthal DN; Guest SS
Isospora belli is an uncommon cause of diarrhea in man. Like the closely related Cryptosporidium, the organism causes disease that may be more severe and chronic in patients with underlying immune deficiency states. We describe three male homosexuals with Isospora enteritis. Each had several months of diarrhea. All th
Simberkoff MS; El Sadr W; Schiffman G; Rahal JJ Jr
Five patients had Streptococcus pneumoniae infections among the 35 hospitalized with acquired immune deficiency syndrome (AIDS) at the New York Veterans Administration Medical Center between January 1, 1982, and June 30, 1983. Three of these patients had pneumococcal bacteremia and 2 had pneumonia without bacteremia.
Biopsy and/or autopsy material from lymphoreticular and other organs was studied in 8 children with suspected acquired immune deficiency syndrome (AIDS). One or both parents of each of these children had one or more of the recognized risk factors for AIDS, such as intravenous drug abuse, prostitution, Haitian origin.
Lotze MT; Robb RJ; Sharrow SO; Frana LW; Rosenberg SA
Twelve patients were treated in a Phase I trial of purified human interleukin-2 ( IL-2 ) derived from the JURKAT cell line (E.I. duPont Corp., Glenolden, PA, U.S.A.). The serum half-life, toxicity, and in vivo immunologic effects of IL-2 were studied in patients with can
Fifteen patients with acquired immunodeficiency syndrome (AIDS), lymphoma and immunodeficiency, or severe combined immunodeficiency were treated with highly purified interleukin-2 ( IL-2 ) prepared from human lymphocytes. All patients showed a defect in mitogen-induced T
Lane HC; Siegel JP; Rook AH; Masur H; Gelmann EP; Quinnan GV; Fauci AS
Twelve patients with acquired immunodeficiency syndrome were treated with a natural product, highly purified human interleukin-2. Doses ranged from 250 to 250,000 units. No clinical responses were seen. Minimal toxicity was noted and consisted of mild prolongation of partial thromboplastin time and proteinuria. Immuno
A mail survey sent to 25 hemophilia centers in France enquiring on the occurrence of AIDS or AIDS-related disorders was done in May 1983. Of 2 388 hemophiliacs representing approximately 60% of the total expected population, no case of AIDS was found. Four patients had lymphodenopa
Ten patients were identified at Jackson Memorial hospital/University of Miami Hospitals and Clinics with enteric coccidial infection due to Cryptosporidium spp. or Isospora belli. All had the acquired immunodeficiency syndrome as manifested by Kaposi s sarcoma or multiple opportunistic infections, or both. They presen
Shelhamer JH; Ognibene FP; Macher AM; Tuazon C; Steiss R; Longo D; Kovacs JA; Parker MM; Natanson C; Lane HC; et al
Eleven patients with acquired immunodeficiency syndrome (AIDS) and Pneumocystis carinii pneumonia (PCP) were studied by repeat bronchoscopy during PCP treatment to assess histologic evidence of resolution of the pneumonia. Nine of 10 patients studied after 8 to 21 days of therapy demonstrated evidence of persistent PC
Coleman DL; Hattner RS; Luce JM; Dodek PM; Golden JA; Murray JF
We retrospectively examined the sensitivity and specificity of gallium lung scans for detecting Pneumocystis carinii pneumonia in 22 patients with known or suspected acquired immune deficiency syndrome. Correlations were made between bronchoscopic results and gallium scan findings interpreted using a simple system (no
Experientia. 1984 Nov 15;40(11):1181-5. Unique Identifier : AIDSLINE MED/85051741
Kendall MD
Recent immunological research has concentrated on the complex and subtle interactions between T cells, B cells and accessory cells. In these studies, little attention has been given to the adult thymus gland. Modern textbooks of disease and anatomy all stress that the gland undergoes fatty involution with age in man b
Numerous clinical and immunological manifestations are commonly observed in AIDS patients. Among these, Kaposi s sarcoma and major opportunistic infections appear today as clinical markers of the disease. Other signs and symptoms such as fever, diarrhea, lymphadenopathy and immunological abnormalities are currently re
We studied lymphocyte subpopulations, serum beta 2 microglobulin, and viral markers in 115 hemophiliacs who are followed and treated at our center. The only clinical or biological anomaly observed is hypergammaglobulinemia. This frequent finding is independent of hemophilia type and of the intensity of substitutive tr
Quantitative analysis of beta-2-microglobulin (beta-2-M) may be a useful test for early diagnosis of acquired immuno-deficiency syndrome (AIDS). Even if beta-2-M is an unspecific marker, 96% of 45 patients with confirmed AIDS and 82% of 45 patients with lymphadenopathy have excessive (3 mg/l) beta-2-M value. beta-2-M
A population including homosexual or heroinoman patients with lymphadenopathy is reported with special reference to Beta-2-microglobulin. This molecule seems to be more related to concomitant infection rather than to a high risk group. Thus, elevated Beta-2-microglobulin is useful to exclude infected donors but no hig
Patients with combined addictive disease are frequently encountered in New York City. Three detoxification schedules have been developed which, alone or in combination, may be used for almost all substance abusers who require pharmacologic detoxification. Numerous factors contribute to pathogenesis of infections in pa
Cancer. 1984 Dec 1;54(11 Suppl):2795-806. Unique Identifier : AIDSLINE MED/85048618
Oldham RK; Thurman GB; Talmadge JE; Stevenson HC; Foon KA
Biologicals and biological response modifiers (BRMs) represent a new class of agents for cancer therapy. Historically, there have been many attempts to stimulate the immune response with nonspecific immunomodulators in the form of bacterial extracts, viruses, and chemicals. Although these approaches have occasionally
Between early 1980 and early 1984, more than 4000 cases of AIDS have occurred in the United States . Since January 1982, 33 cases have occurred in patients with hemophilia. The epidemiologic and clinical features of the cases are presented. Etiologic considerations and implications for
A major haemophiliac A, 27 years old, has been treated during 30 months, with high dosage of imported Factor VIII, in order to reduce the titer of a F VIII antibody. A good clinical result has been obtained. No sign of immunodeficiency has been observed. Normal values were obtained for T4/T8, ratio B2 microglobulin an
The occurrence during the last 2 years of 29 cases of AIDS in hemophiliacs (21 in USA and 8 in Europe) suggests possible transmission of this disease by blood products. All these patients had received Factor VIII or IX concentrates and developed pneumocystis carinii pneumonia or other opportunistic infections. Kaposi
Peripheral blood mononuclear cells from male homosexuals with acquired immune deficiency syndrome (AIDS) and with AIDS related complex (ARC) were examined for the autologous mixed lymphocyte reaction (AMLR) between responder T and irradiated autologous non-T cells and in vitro influence of purified human interleukin-1
Cell surface marker analyses conducted on human peripheral blood lymphoid cells have proven extremely useful in the diagnosis of immunodeficiency and the diagnosis and staging of malignancies. In this paper we have focused on the ratio of helper to suppressor cells in patients with the acquired immune deficiency syndr
JAMA. 1984 Dec 28;252(24):3375-7. Unique Identifier : AIDSLINE MED/85058553
Sacks HS; Rose DN; Chalmers TC
The current epidemic of acquired immunodeficiency syndrome (AIDS) and fear that its causative agent contaminates the currently available hepatitis B vaccine may have deterred vaccine use. We formulated a decision-analytic model that compares the risk of death from hepatitis B and AIDS in those vaccinated with the risk
Due to the high frequency and variety of the mucous cutaneous signs, the dermatologists are facing many cases of AIDS. These signs are no specific but only the consequence of a cellular immunodeficiency; they can be encountered in other situations, more specifically after an immunosuppressive treatment. Therefore, the
Am J Med. 1984 Dec;77(6):1023-6. Unique Identifier : AIDSLINE MED/85069521
Littenberg B; Ransohoff DF
Three strategies regarding hepatitis B virus vaccination were compared by decision analysis: no vaccination, immediate vaccination, and vaccination after two years. The potential advantage of waiting two years is to learn whether serious side effects of the vaccine will become evident. For example, it was found that i
Human sera contain antigens and also circulating immune complexes that are related to the primate retroviral envelope glycoprotein gp70 of simian sarcoma/simian sarcoma associated virus (SiSV) and of gibbon ape leukemia virus (GaLV). SiSVgp70 related antigens (AG) and immune complexes (IC) are detected both in leukemi
Modern transfusion practice is associated with an increased risk of transmitting viral agents because of the changing nature of the patients and of the therapeutic blood products. More immunosuppressed patients are receiving blood released faster and with more elaborate blood components. In addition to the classically
In the absence of a specific diagnostic test for AIDS, a case can be recognized only when complications of the immune deficiency such as opportunistic infections or Kaposi s sarcoma occur. Defective T-cell function is the principal immunological defect; however, there are defects in B-cell function which may have some
Patients with bacteremia, bacterial endocarditis, or acquired immunodeficiency syndrome (AIDS) were prospectively studied using monoclonal antibody reagents to assess alterations in T-lymphocyte subpopulations. Patients with endocarditis had significantly higher ratios of T-helper (OKT4+) to T-suppressor-cytotoxic (OK
Dtsch Med Wochenschr. 1984 Nov 9;109(45):1709-11. Unique Identifier : AIDSLINE MED/85050798
Wernicke D; v. d. Helm K; Abb J; Eberle J; Zoulek G; Pleyl G; Deinhardt F; Riethmuller G; Ziegler-Heitbrock HW; Rieber EP; et al
HTLV III and LAV, retroviruses which have recently been described in the United States and France and which seem to be different isolates of the same virus, are closely associated with the acquired immune deficiency syndrome (AIDS) and the lymphaden
The data concerning retrovirus HTLV isolated from patients with T-cell leukemia/lymphoma are presented. The virus differs from the known C type viruses, possesses high tropism to T-lymphocytes. The virus is exogenous for human cells and its origin is still unknown. Virus specific nucleotide sequences are absent in a n
FEBS Lett. 1984 Nov 19;177(2):200-4. Unique Identifier : AIDSLINE MED/85051846
Okai Y; Oka T; Akagi T; Kurata S; Fujiyoshi N
Some characteristics of T cell growth factors derived from adult T cell leukemia virus (ATLV)-transformed cell lines, MT 1 and MT 2 were analyzed. MT 1 cells release significant interleukin 2 (IL 2) activity into the culture medium, which showed the same elution pattern of gel filtration and isoelectric focusing of IL
FEBS Lett. 1984 Dec 3;178(1):79-82. Unique Identifier : AIDSLINE MED/85051885
Sagata N; Yasunaga T; Ikawa Y
The genomes of bovine leukemia and human T-cell leukemia viruses both contain an unidentified region between the gag and pol genes. These regions harbor an open reading frame that is in a different phase from the reading frames of the gag and pol genes. Based on the deduced amino acid sequences, we show here that they
Kiyokawa T; Seiki M; Imagawa K; Shimizu F; Yoshida M
A protein p40x was identified as a product encoded by frame IV in the pX region of human T-cell leukemia virus type I. Sera from patients with adult T-cell leukemia contained antibodies against p40x, indicating its expression in vivo. The occurrence of splicing to form pX mRNA is proposed and the possible significance
Miwa M; Shimotohno K; Hoshino H; Fujino M; Sugimura T
A 41-kilodalton protein was detected in four human T-cell leukemia virus type I (HTLV-I)-infected cell lines, a 68-kilodalton glycoprotein in MT-2 cells, and a 38-kilodalton protein in an HTLV-II-infected cell line by using antibody against a synthetic dodecapeptide, a portion of the polypeptide deduced from the nucle
Jacalin, a lectin(s) extracted from the seeds of Artocarpus integrifolia (Jackfruit), was shown to induce the production of gamma interferon (IFN gamma) in human peripheral blood mononuclear cells (PBMC) and human T-lymphocyte cultures. The amount of IFN gamma produced was enhanced in the presence of mezerein, a phorb
Int J Cancer. 1984 Nov 15;34(5):613-8. Unique Identifier : AIDSLINE MED/85053565
Hahn BH; Shaw GM; Popovic M; Lo Monico A; Gallo RC; Wong-Staal F
We report the identification and characterization of a new variant of HTLV-I in an African patient with adult T-cell leukemia/lymphoma (ATL). Proviral sequences were detected by Southern blot analysis in three T-cell lines established from this patient s peripheral blood lymphocytes (PBL) and lymph-node cells. We mole
Int J Cancer. 1984 Nov 15;34(5):667-70. Unique Identifier : AIDSLINE MED/85053573
Schaffar-Deshayes L; Chavance M; Monplaisir N; Courouce AM; Gessain A; Blesonski S; Valette I; Feingold N; Levy JP
Human T-cell lymphoma/leukemia virus type I (HTLV-I) is a type-C retrovirus originally isolated from patients with leukemia or lymphoma involving mature T lymphocytes. Epidemiological studies have shown that HTLV-I infection occurs not only in leukemic but also in normal people in at least two areas of the world: the
Herpes zoster is common in the elderly. Persons over the age of 50 years have an attack rate double that of patients less than 50 years old. In the very aged, this rate nearly doubles again. The loss of cell-mediated immunity for the VZ virus appears to be the primary factor in the disruption of the dynamic containmen
Fukui K; Noma T; Takeuchi K; Kobayashi N; Hatanaka M; Honjo T
Adult T-cell leukemia virus (ATLV) is a retrovirus infecting man. The ATLV genome consists of long terminal repeat (LTR), gag, pol, env and pX sequences and does not carry a typical v-onc gene. The function of the pX sequence is unknown. To search for the origin of ATLV, segments of the ATLV genome were hybridized to
Cultured haemic cells from an AIDS patient were found to produce a morphologically new virus, not adult T-cell leukaemia virus (ATLV). Sera from 35 promiscuous homosexuals, 10 with and 25 without AIDS, did not have antibodies to ATLV (HTLV), but the sera of 6 of those patients reacted with cultured cells from the AIDS
Four human T cell lines, MT-2, TCL-Kan, TCL-As 2, and TCL-Haz, established from normal leukocytes by cocultivation with adult T-cell leukemia (ATL) virus (ATLV)-producing cells, produced constitutively phagocytosis inducing factor(s) (PIF) that induced phagocytosis in a human monocytic cell line, THP-1. These cell lin
Med Microbiol Immunol (Berl). 1984;173(3):127-40. Unique Identifier : AIDSLINE MED/85060725
Koyanagi Y; Hinuma Y; Schneider J; Chosa T; Hunsmann G; Kobayashi N; Hatanaka M; Yamamoto N
The adult T-cell leukemia (ATL)-associated antigen complex (ATLA) was first discovered with indirect immunofluorescence by Hinuma et al. (1981). Biochemical analysis with MT-2 cells revealed that ATLA consisted mainly of human T-cell leukemia virus (HTLV) structural polypeptides and their precursors (Yamamoto and Hinu
Med Microbiol Immunol (Berl). 1984;173(3):167-70. Unique Identifier : AIDSLINE MED/85060729
Hunsmann G; Bayer H; Schneider J; Schmitz H; Kern P; Dietrich M; Buttner DW; Goudeau AM; Kulkarni G; Fleming AF
Almost 4000 sera from seven African states were examined for antibodies to ATLV/HTLV-1. Between 1% and 8% of healthy people from sub-Saharan Africa have such antibodies. The highest frequency was observed in Gabon . There were considerable variations between villages. The percentage
Nature. 1984 Nov 8-14;312(5990):166-9. Unique Identifier : AIDSLINE MED/85061506
Hahn BH; Shaw GM; Arya SK; Popovic M; Gallo RC; Wong-Staal F
We recently reported the isolation and characterization of a novel human T-lymphotropic retrovirus, HTLV-III, in patients with acquired immune deficiency syndrome (AIDS) and in those at risk for the disease. After extensive sero-epidemiological studies, together with numerous virus isolations from these patients, we c
Nature. 1984 Nov 15-21;312(5991):275-7. Unique Identifier : AIDSLINE MED/85061531
Suciu-Foca N; Rubinstein P; Popovic M; Gallo RC; King DW
T-cell lines established from individuals infected with human T-cell leukaemia virus (HTLV) or generated by co-cultivation of normal human T cells with HTLV-infected T-cells, express class II (HLA-D/DR or Ia) antigens of the major histocompatibility complex (MHC) and interleukin-2 (
Human T-cell leukaemia virus type III (HTLV-III) is suspected of having a key role in the pathogenesis of acquired immune deficiency syndrome (AIDS). Epidemiological data suggest that AIDS is transmitted by an infectious agent through intimate contact with body secretions, blood or blood products. To maintain haemosta
Proc Natl Acad Sci U S A. 1984 Dec;81(23):7441-5. Unique Identifier : AIDSLINE MED/85063806
Sugamura K; Fujii M; Kobayashi N; Sakitani M; Hatanaka M; Hinuma Y
We provide direct evidence for interleukin 2 receptor (IL2R) induction by human T-cell leukemia/lymphoma virus (HTLV) in human B-cell lines. A lymphoblastoid B-cell line (LCL-Ter) was established by Epstein-Barr virus-induced transformation of peripheral blood lymphocytes derived from a healthy HTLV carrier and cloned
The viral (v)-sis oncogene encodes a protein (p28sis) that is structurally homologous to platelet-derived growth factor (PDGF). We have shown that simian sarcoma virus (SSV)-transformed cells containing the v-sis oncogene release a Mr 20,000 substance that is recognized by antisera to synthetic peptide sequences conta
Proc Natl Acad Sci U S A. 1984 Dec;81(23):7579-83. Unique Identifier : AIDSLINE MED/85063834
Lee TH; Coligan JE; McLane MF; Sodroski JG; Popovic M; Wong-Staal F; Gallo RC; Haseltine W; Essex M
People exposed to type I human T-cell leukemia virus (HTLV-I) develop antibodies to an antigen at the surface of virus-infected cells, designated human T-cell leukemia virus membrane antigen (HTLV-MA). In an earlier study, we demonstrated that the major component of HTLV-MA is gp61, a glycoprotein encoded by the HTLV
Proc Natl Acad Sci U S A. 1984 Dec;81(23):7588-90. Unique Identifier : AIDSLINE MED/85063836
Ho DD; Rota TR; Hirsch MS
We studied the effects of human T-lymphotropic virus type I (HTLV-I) on human endothelial cells in vitro. During cocultivation with an HTLV-I producer cell line (C91/PL), endothelial cells formed characteristic multinucleated syncytial giant cells. Inoculation with concentrated cell-free supernatant fluid from C91/PL
Proc Natl Acad Sci U S A. 1984 Dec;81(23):7591-5. Unique Identifier : AIDSLINE MED/85063837
Hoxie JA; Matthews DM; Cines DB
The effects of the human T-cell leukemia virus type I (HTLV-I) on cultured human endothelial cells were evaluated. Coculture of endothelial monolayers with either irradiated HTLV-producing lymphocytes or cell-free virus resulted in the production of multinucleated syncytia. The development of syncytia was inhibited by
Viral interactions may occur whenever a host is infected simultaneously with two viruses. Persons at high risk for acquired immunodeficiency syndrome (AIDS) may provide a substrate for such interactions. These could include complementary immunosuppression, potentiation of infection by altered receptors or genetic comp
Acquired immune deficiency syndrome (AIDS) in many aspects resembles formerly recognized immune deficiencies, but in its complexity and presumed viral etiology, it is a unique entity. Examples of overlapping features of AIDS and immune defects, infectious complications, and neoplasms are discussed. It is not known wha
All the epidemiological features suggest that the acquired immunodeficiency syndrome (AIDS) is caused by a single transmissible agent and surely a virus. First, cytomegalovirus , Epstein-Barr virus and hepatitis B virus have been proposed as possible etiological agents of AIDS. A di
Schaffar-Deshayes L; Courouce AM; Monplaisir N; Chavance M; Levy JP
HTLV infection was detected in normal French blood donors and haemophiliac patients using HTLV p24 radio-immunoassay. No positive was found in 772 sera from continental blood donors born in continental France or in foreign countries. Among 131 donors living in continental France an
From July 1983 to January 1984 (7 months) information on AIDS and high-risk groups was given to each blood donor. A total of 139 subjects out of 136 384 (1.02%) declared to belong to such groups. Their blood donations were reserved to research purpose. Anti-HBc antibody was present in 43 subjects (31 %) in a frequency
Falkenrodt A; Schwartz G; North ML; Schwartz M; Weill D; Schmitthauesler R; Hun H; Malgras J; Mayer S
The prison population may be considered as a population at risk for AIDS. Biological parameters were studied in order to detect significant anomalies commonly observed in AIDS patients. With respect to are age matched control population of donors, there are no statistically significant differences concerning the nutri
Noel L; Messian O; Grand M; Lambotin B; Courouce AM; Saint-Paul B
212 male prisoners were collected at the prison in March 1983. Anti-HBc and HBs Ag were detected by a combined test (AUSRIA-CORE, Abbott Laboratories ). 67 sera (31,5%) were anti-HBc positive, 7 of them HBs Ag positive. Screening for anti-HTLV (anti-p24) was negative for all the do
A transmissible agent especially a retrovirus (HTLV, LAV), is now widely considered in AIDS etiology. Similarities do exist between the epidemiology of AIDS and hepatitis B virus infections. Therefore, recommendations for preventing potential transmissions of AIDS are similar to those for preventing hepatitis B transm
The human T-cell leukemia (lymphotropic) virus type III (HTLV-III) appears to be central to the causation of the acquired immune deficiency syndrome (AIDS). Two full-length integrated proviral DNA forms of HTLV-III have now been cloned and analyzed, and DNA sequences of the virus in cell lines and fresh tissues from p
Science. 1984 Dec 7;226(4679):1197-9. Unique Identifier : AIDSLINE GENBANK/K02085
Hannink M; Donoghue DJ
The protein encoded by the simian sarcoma virus oncogene (v-sis) contains a signal sequence, derived from the envelope gene of the parental retrovirus, which is required for transformation. Removal of the proposed signal sequence was correlated with loss of biological activity. This activity was restored to inactive d
HCL is a lymphoproliferative disorder, primarily of B cells. T cell variant HCL is a rare clinical entity, which has a clinical picture similar to that of the common B cell HCL disease. HTLV-II has been isolated from a case of T cell variant HCL. This subtype of HTLV-II-associated disease is indolent in character in c
Am Fam Physician. 1984 Dec;30(6):131-44. Unique Identifier : AIDSLINE MED/85069139
Macher AM
A retrovirus designated HTLV-III has been recovered from patients with AIDS and patients with pre-AIDS syndrome. This virus, which appears to be the cause of AIDS, attacks and suppresses T-helper lymphocytes, rendering the host susceptible to a variety of serious protozoal, fungal, mycobacterial, bacterial and viral i
Thirty-one out of 40 patients with the acquired immune deficiency syndrome examined at autopsy had significant central nervous system disease. A subacute encephalitis, found in 19 patients, was the most frequent finding and was characterized by marked brain atrophy and a progressive dementing illness. This entity is l
Lancet. 1984 Dec 15;2(8416):1367-9. Unique Identifier : AIDSLINE MED/85059996
McCormick JB; Getchell JP; Mitchell SW; Hicks DR
The in-vitro effect of ribavirin on the replication of lymphadenopathy-associated virus (LAV), one of the prototype viruses aetiologically associated with lymphadenopathy syndrome and acquired immunodeficiency syndrome, was tested. Ribavirin, a nucleoside, suppressed the replication of LAV in cultures of human adult T
Volatile nitrite in the form of amyl nitrite was used for 100 years for the treatment of angina pectoris. In spite of recognized toxicity, its use in this form was considered safe. During the 1960s prescriptions were not required for purchase of amyl nitrite (called poppers) and its use for recreational purposes becam
Depressed T cell immunity is a universal characteristic of the acquired immunodeficiency syndrome (AIDS). In the present study, 25 patients with AIDS and opportunistic infections, 22 individuals with AIDS-related complex (ARC, or chronic lymphadenopathy syndrome), and 20 healthy homosexuals were evaluated by means of
Lotze MT; Frana LW; Sharrow SO; Robb RJ; Rosenberg SA
A total of 12 patients with cancer or the acquired immunodeficiency syndrome have been treated with Jurkat-derived purified human interleukin 2 (IL 2). The toxicity was dose-related and consisted primarily of fever, chills, malaise, and mild reversible hepatic dysfunction. No evidence of clinical efficacy was seen whe
We report 2 homosexual patients with the acquired immune deficiency syndrome and histopathologic evidence for cytomegalovirus colitis. In each case, the initial endoscopic impression was Kaposi s sarcoma but the appropriate diagnosis was made by histologic demonstration of a cytome
N Engl J Med. 1985 Jan 3;312(1):1-4. Unique Identifier : AIDSLINE MED/85061430
Hirsch MS; Wormser GP; Schooley RT; Ho DD; Felsenstein D; Hopkins CC; Joline C; Duncanson F; Sarngadharan MG; Saxinger C; et al
Infection with human T-cell lymphotropic virus III (HTLV-III) is closely linked to the acquired immunodeficiency syndrome (AIDS). We evaluated the risk of nosocomial infection with HTLV-III by testing for antibodies to HTLV-III among hospital employees, including victims of needle-stick exposure, endoscopists, patholo
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