Comparison of the entire genomes of bovine leukemia virus and human T-cell leukemia virus and characterization of their unidentified open reading frames. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Comparison of the entire genomes of bovine leukemia virus and human T-cell leukemia virus and characterization of their unidentified open reading frames.

EMBO J. 1984 Dec 20;3(13):3231-7. Unique Identifier : AIDSLINE MED/85126931
Sagata N; Yasunaga T; Ohishi K; Tsuzuku-Kawamura J; Onuma M; Ikawa Y

Abstract: We have compared the sequence of the entire genomes of bovine leukemia virus (BLV) and human T-cell leukemia virus type I (HTLV-I). Both the gag and pol genes show overall strong homologies indicating the close evolutionary relationship of the two retroviruses. However, a surface glycoprotein portion of the env gene shows no appreciable homology, which probably reflects a difference in their host ranges. The 3' end portion of the BLV genome (designated as pXBL) contains an unidentified long open reading frame that has a typical protein-coding property. The potential product of this open reading frame may be a glycoprotein of approximately 40 000 daltons. We note that its amino acid sequence shows low but appreciable homology, especially in its N-terminal quarter, to that of the HTLV-I counterpart (pX product), and we thus suggest that BLV pXBL and HTLV-I pX have diverged from a common ancestral gene. It is tentatively concluded that both the putative pXBL and pX products are respectively produced from a spliced mRNA.
Keywords: Amino Acid Sequence Base Sequence Comparative Study Evolution Genes, Structural *Genes, Viral Glycoproteins/GENETICS HTLV-BLV Viruses/*GENETICS Leukemia Virus, Bovine/*GENETICS Retroviridae/*GENETICS RNA Splicing Support, Non-U.S. Gov't Viral Proteins/GENETICS JOURNAL ARTICLE

KWDaminoacidsequencebasesequencecomparativestudyevolutiongenes,structuralKWDgenes,viralglycoproteins/geneticshtlv-blvviruses/KWDgeneticsleukemiavirus,bovine/KWDgeneticsretroviridae/KWDgeneticsrnasplicingsupport,non-uKWDsKWDgov'tviralproteins/geneticsjournalarticle
850630
M8560145

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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