[New knowledge on the molecular mechanism of activation of oncogenes and effect of oncogene DNA on protein synthesis] NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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[New knowledge on the molecular mechanism of activation of oncogenes and effect of oncogene DNA on protein synthesis]

Z Gesamte Inn Med. 1984 Dec 15;39(24):605-11. Unique Identifier : AIDSLINE MED/85144448
Kolb E

Abstract: It is reported on recent recognitions in the activation of cellular oncogens by carcinogens, by exchange (translocation) of genes within various chromosomes as well as by infection by the proviruses DNA of retroviruses. Cellular oncogens can be activated by a mutation already by the exchange of a base in a desoxyribonucleotide. Mutations develop under the influence of carcinogens. The protein changed in a amino acid portion accepts transforming properties. The Epstein-Barr virus furthers the increase of the number of B-lymphocytes. In this case may take place a translocation of the oncogen c-myc of the chromosome 8 into the region of the gen-recombination for the formation of the polypeptide chains of the immunoglobulins in the chromosomes 2, 14, and 22, respectively: in this area is an acceleration factor for the transcription. Cellular oncogens may be activated by retroviruses also by the long terminal repetitive parts of the proviruses. Papilloma viruses relatively frequently appear in the carcinomas of the cervix.
Keywords: Animal Chromosome Mapping DNA, Neoplasm/*GENETICS DNA, Viral/GENETICS English Abstract Genetic Code Genetics, Biochemical Herpesvirus 4, Human/GENETICS Human HTLV-BLV Viruses/GENETICS Mutation Neoplasm Proteins/*BIOSYNTHESIS *Oncogenes Retroviridae Infections/GENETICS Translocation (Genetics) Tumor Virus Infections/GENETICS Virus Activation JOURNAL ARTICLE

KWDanimalchromosomemappingdna,neoplasm/KWDgeneticsdna,viral/geneticsenglishabstractgeneticcodegenetics,biochemicalherpesvirus4,human/geneticshumanhtlv-blvviruses/geneticsmutationneoplasmproteins/KWDbiosynthesisKWDoncogenesretroviridaeinfections/geneticstranslocation(genetics)tumorvirusinfections/geneticsvirusactivationjournalarticle
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M8560137

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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