Pathologic pulmonary findings in children with the acquired immunodeficiency syndrome: a study of ten cases. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Pathologic pulmonary findings in children with the acquired immunodeficiency syndrome: a study of ten cases.

Hum Pathol. 1985 Mar;16(3):241-6. Unique Identifier : AIDSLINE MED/85129151
Joshi VV; Oleske JM; Minnefor AB; Saad S; Klein KM; Singh R; Zabala M; Dadzie C; Simpser M; Rapkin RH

Abstract: Lung tissue and tissue from the lymphoreticular system obtained at open biopsy and/or autopsy were studied in ten children with the acquired immunodeficiency syndrome (AIDS). One or both parents of nine of the children had AIDS or risk factors for AIDS. The remaining child had hemophilia. The following pulmonary lesions were seen: 1) diffuse alveolar damage (DAD), 2) Pneumocystis carinii and/or cytomegalovirus pneumonitis, 3) lymphoid interstitial pneumonitis (LIP), and 4) desquamative interstitial pneumonitis (DIP). Combinations of such factors as mechanical ventilation, oxygen therapy, and opportunistic infection played a role in the pathogenesis of DAD. Opportunistic infections were related to the defective cell-mediated immunity in these children. The clinical, epidemiologic, immunologic, and pathologic features of the thymuses of these patients indicate that the immune deficiency was unlikely to have been of congenital origin. The immunologic abnormalities may also have been related to the pathogenesis of LIP and DIP. Neither LIP nor DIP has been described in adults with AIDS. Open lung biopsy is of practical importance in the diagnosis and treatment of pulmonary disease in children with AIDS.
Keywords: Acquired Immunodeficiency Syndrome/IMMUNOLOGY/*PATHOLOGY Biopsy Child Child, Preschool Female Human Infant Infant, Newborn Lung/*PATHOLOGY Male Pulmonary Fibrosis/IMMUNOLOGY/PATHOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/immunology/KWDpathologybiopsychildchild,preschoolfemalehumaninfantinfant,newbornlung/KWDpathologymalepulmonaryfibrosis/immunology/pathologyjournalarticle
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Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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