Kaposi's sarcoma causing pulmonary infiltrates and respiratory failure in the acquired immunodeficiency syndrome. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Kaposi's sarcoma causing pulmonary infiltrates and respiratory failure in the acquired immunodeficiency syndrome.

Ann Intern Med. 1985 Apr;102(4):471-5. Unique Identifier : AIDSLINE MED/85147113
Ognibene FP; Steis RG; Macher AM; Liotta L; Gelmann E; Pass HI; Lane HC; Fauci AS; Parrillo JE; Masur H; et al

Abstract: Although an aggressive form of Kaposi's sarcoma often develops in patients with the acquired immunodeficiency syndrome, most patients die due to opportunistic infections rather than the direct effects of this tumor. Because Kaposi's sarcoma has caused pulmonary dysfunction in a number of our patients, we attempted to characterize features of pulmonary dysfunction induced by Kaposi's sarcoma. In 66 patients with Kaposi's sarcoma treated between 1982 and 1984 there were 30 episodes of pulmonary dysfunction that resulted in a biopsy. Six episodes were due to pulmonary Kaposi's sarcoma alone, and 6 additional episodes were due to Kaposi's sarcoma and associated opportunistic infections. Clinical and radiologic features of pulmonary Kaposi's sarcoma an infection were indistinguishable. Pulmonary Kaposi's sarcoma could only be documented in large tissue sections available from open-lung biopsy or autopsy samples. Because chemotherapy or radiation therapy appears to provide palliation, clinicians should recognize Kaposi's sarcoma as a cause of pulmonary disease in patients with the acquired immunodeficiency syndrome.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Antineoplastic Agents, Combined/THERAPEUTIC USE Biopsy Human Lung Neoplasms/*COMPLICATIONS/PATHOLOGY/THERAPY Lymph Nodes/PATHOLOGY Pleural Effusion/ETIOLOGY Pneumonia/ETIOLOGY Pulmonary Fibrosis/ETIOLOGY Respiratory Insufficiency/*ETIOLOGY Sarcoma, Kaposi's/*COMPLICATIONS/PATHOLOGY/THERAPY Skin/PATHOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDcomplicationsantineoplasticagents,combined/therapeuticusebiopsyhumanlungneoplasms/KWDcomplications/pathology/therapylymphnodes/pathologypleuraleffusion/etiologypneumonia/etiologypulmonaryfibrosis/etiologyrespiratoryinsufficiency/KWDetiologysarcoma,kaposi's/KWDcomplications/pathology/therapyskin/pathologyjournalarticle
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M8560102

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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