Acquired immunodeficiency syndrome. Distinctive features of bone marrow biopsies. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Acquired immunodeficiency syndrome. Distinctive features of bone marrow biopsies.

Arch Pathol Lab Med. 1985 Feb;109(2):138-41. Unique Identifier : AIDSLINE MED/85148413
Geller SA; Muller R; Greenberg ML; Siegal FP

Abstract: Bone marrow biopsies from 30 patients with acquired immunodeficiency syndrome (AIDS), diagnosed according to accepted clinical criteria, were studied in order to determine if characteristic histopathologic features were present. The biopsies were compared with 20 biopsy specimens submitted from patients with fever of unknown origin or with known neoplastic disease, including four biopsies from patients with a history of narcotics addiction being treated in the methadone clinic, and with biopsies from three homosexual men who did not have AIDS. Characteristic biopsy features were recognized in 31 (86%) of 36 biopsy specimens from AIDS patients. Nineteen of 36 patients (53%) showed a distinctive pattern of hypercellularity in which hematic cells (immature granulocytic cells, megakaryocytes, eosinophils, and large lymphocytes) separated, but did not efface, fat cells; these cells were designated as AIDS-pattern. Twelve specimens showed a less complete (probable-AIDS) bone marrow change. Reticulin fibers were increased in 28 of 36 biopsies.
Keywords: Acquired Immunodeficiency Syndrome/*PATHOLOGY Adult Biopsy, Needle Bone Marrow/*PATHOLOGY Female Histocytochemistry Homosexuality Human Hyperplasia/PATHOLOGY Male Narcotic Dependence/PATHOLOGY Reticulin/ANALYSIS JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDpathologyadultbiopsy,needlebonemarrow/KWDpathologyfemalehistocytochemistryhomosexualityhumanhyperplasia/pathologymalenarcoticdependence/pathologyreticulin/analysisjournalarticle
850630
M8560096

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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