Immunocytologic localization of herpes simplex type 1 viral antigens in herpetic retinitis and encephalitis in an adult. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Immunocytologic localization of herpes simplex type 1 viral antigens in herpetic retinitis and encephalitis in an adult.

Ophthalmology. 1985 Jan;92(1):160-6. Unique Identifier : AIDSLINE MED/85139099
Pepose JS; Kreiger AE; Tomiyasu U; Cancilla PA; Foos RY

Abstract: An immunoperoxidase technique was utilized to identify herpes simplex type I viral antigens in the retina, optic nerve and brain of an adult with herpetic retinitis and encephalitis. Viral antigens were demonstrated in all layers of retina, retinal pigment epithelium and to a lesser extent, in choroid. Oligodendroglia in the right optic nerve and neuronal and glial cells in the grey and white matter of the left frontal, inferior parietal and temporal lobes of the brain also expressed herpes simplex antigens. The sensitive immunoperoxidase method allowed detection of viral antigens in many cells without intranuclear inclusions or surrounding inflammation, and thereby added valuable information regarding the anatomic and cellular localization of herpetic infection. The clinicopathologic features that characterize herpes simplex retinitis in the adult are compared to cytomegalovirus retinopathy.
Keywords: Acquired Immunodeficiency Syndrome/PATHOLOGY Aged Antibodies, Monoclonal/DIAGNOSTIC USE Antigens, Viral/*ANALYSIS Brain/PATHOLOGY Case Report Encephalitis/IMMUNOLOGY/*PATHOLOGY Herpes Simplex/IMMUNOLOGY/*PATHOLOGY Human Immunoenzyme Techniques Male Optic Nerve/PATHOLOGY Retina/PATHOLOGY Retinitis/IMMUNOLOGY/*PATHOLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/pathologyagedantibodies,monoclonal/diagnosticuseantigens,viral/KWDanalysisbrain/pathologycasereportencephalitis/immunology/KWDpathologyherpessimplex/immunology/KWDpathologyhumanimmunoenzymetechniquesmaleopticnerve/pathologyretina/pathologyretinitis/immunology/KWDpathologysupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
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M8560080

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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