AIDS surveillance in haemophilia. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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AIDS surveillance in haemophilia.

Br J Haematol. 1985 Feb;59(2):383-90. Unique Identifier : AIDSLINE MED/85122547
Daly HM; Palmer R; Scott GL; Lee G

Abstract: We suspected a patient attending our Haemophilia Centre had developed Acquired Immunodeficiency Syndrome (AIDS) and therefore immunological evaluation was performed on 43 patients with haemophilia and von Willebrand's disease attending the Centre. The index patient died of Pneumocytis carinii pneumonia. Thirty-one patients had either abnormal T cell subsets or helper/suppressor ratios. Thirty-two patients had hypergammaglobulinaemia. There was no direct correlation between these immunological abnormalities and the total amount or type of treatment received. T cell abnormalities were not confined to the 13 patients who had received the same batches of concentrate as the index case. The index case simultaneously contracted hepatitis B. He was the only patient to receive a large amount of the suspect batches of concentrate, not previously immune to hepatitis B.
Keywords: von Willebrand's Disease/COMPLICATIONS/IMMUNOLOGY Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adolescence Adult Aged Christmas Disease/COMPLICATIONS/IMMUNOLOGY Factor VIII/THERAPEUTIC USE Female Hemophilia/*COMPLICATIONS/IMMUNOLOGY/THERAPY Human Immunoglobulins/ANALYSIS Leukocyte Count Lymphocytes Male Middle Age Support, Non-U.S. Gov't T-Lymphocytes/CLASSIFICATION JOURNAL ARTICLE

KWDvonwillebrand'sdisease/complications/immunologyacquiredimmunodeficiencysyndrome/KWDcomplicationsadolescenceadultagedchristmasdisease/complications/immunologyfactorviii/therapeuticusefemalehemophilia/KWDcomplications/immunology/therapyhumanimmunoglobulins/analysisleukocytecountlymphocytesmalemiddleagesupport,non-uKWDsKWDgov'tt-lymphocytes/classificationjournalarticle
850630
M8560077

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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