[Bethesda, Md.] : U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, 1984 21, 6 p (Literature search / National Library of Medicine ; no. 84-9) Unique Identifier : AIDSLINE CAT/8502770
[Bethesda, Md.] : U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, 1984 32, 17 p (Literature search / National Library of Medicine ; no. 84-32) Unique Identifier : AIDSLINE CAT/8502769
[Bethesda, Md.] : U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, [1984] 19, 12 p (Literature search / National Library of Medicine ; no. 84-18) Unique Identifier : AIDSLINE CAT/8502768
Popovic M; Wong-Staal F; Sarin PS; Gallo RC; Lab. of Tumor Cell Biology, Natl. Cancer Inst., Natl. Institutes; of Health, Bethesda, MD 20205
Despite decades of accumulated evidence for the involvement of retroviruses in leukemogenesis in a variety of animals, evidence for an etiologic role of retroviruses in human neoplasias was not available until recently. This discussion of human T-cell leukemia/lymphoma virus (HTLV), a unique exogenous retrovirus relea
Available from National Technical Information Service, Springfield, VA as NTIS/NTN84-0398, 1p 1984. Unique Identifier : AIDSLINE ICDB/85609420
Department of Health and Human Services; Washington, DC.
This citation summarizes a one-page announcement of technology available for utilization. A cell system is disclosed for the reproducible detection and isolation of human T-lymphotropic retroviruses (HTLV-family) with cytopathic effects (HTLV-III) from patients with acquired immune deficiency syndrome (AIDS), pre-AIDS
Previously we observed clinical and histological regression of Kaposi s sarcoma in the skin in a 38-year-old man with AIDS following treatment with Dapsone. This observation initiated the present study where 6 patients with Kaposi s sarcoma in the skin without clinical signs of systemic spreading were treated with Dap
In a 47-year-old male patient with epidermodysplasia verruciformis, pulmonary cryptococcosis and torulopsidosis of at least 7 years duration were detected, after mycotic ulcerous cutaneous lesions had appeared. The immunological findings are in accordance with those of AIDS.
Two homosexual Danish men with the acquired immunodeficiency syndrome (AIDS) contracted cryptosporidium enterocolitis. One patient died in another opportunistic infection, the other developed severe chronic enterocolitis with malabsorption. The cryptosporidia escape detection on routine stool examination, but are easi
This report deals with the case history of a 21/2-year old Turkish boy, who died from an overwhelming mononucleosis infectiosa. The parents, first cousins, lost already two sons and a daughter. According to the parents, the symptoms of these children resembled those of this boy. In the patient, described here, an acqu
Libeskind M; Malbran J; Agard D; Pannetier C; Lecouillard C; Ivanovic A
The proctologist is above all concerned with the known recrudescence of venereal diseases. Examples reviewed are diseases of bacterial origin (syphilis, gonorrhea, soft chancre, donovanosis and chlamydiosis), appropriate antibiotic therapy and diseases of viral origin (herpes, condyloma acuminatum). Also noted are oth
D-erythro-neopterin, a biochemical marker of cell-mediated immune response, was found to be significantly (p less than 0.001) elevated in the serum of homosexual patients with acquired immunodeficiency syndrome and related lymphadenopathy syndrome. The most pronounced rise was observed in viral diseases causing a nume
Reckel RP; Harris J; Botsko E; Wellerson R; Varga S
An ELISA sandwich assay for detecting circulating immune complexes (CIC) was evaluated. Heat-aggregated IgG (HAG) containing Clq (HAG:Clq) is used to generate standard curves for quantitation of CIC. Sera from 488 normal donors had an means of 3.8 +/- 15.3 micrograms/ml HAG eq and 97.1% had concentrations less than 35
The histological features of a distinctive follicular hyperplasia observed in twenty-nine male patients with AIDS or the AIDS related complex are described. The group includes four patients with Kaposi s sarcoma, five with lymphoma, 16 with persistent generalized lymphadenopathy, and four with hemophilia. Histopatholo
Sera of 30 Swedish homosexual men belonging to the group at risk for the acquired immunodeficiency syndrome (AIDS) were examined for antibodies against various opportunistic parasites. Antibodies to Encephalitozoon cuniculi were found in 33%, to Pneumocystis carinii in 43%, and to Toxoplasma gondii in 37%. The results
Infections having atypical mycobacteria are occurring more frequently for 2 main reasons. First there are the disturbances of the immunity system, whether due to the acquired immune deficiency syndrome (AIDS) or the result of therapeutic measures taken against malignant processes, other diseases or after organ transpl
EMBO J. 1984 Dec 20;3(13):3231-7. Unique Identifier : AIDSLINE MED/85126931
Sagata N; Yasunaga T; Ohishi K; Tsuzuku-Kawamura J; Onuma M; Ikawa Y
We have compared the sequence of the entire genomes of bovine leukemia virus (BLV) and human T-cell leukemia virus type I (HTLV-I). Both the gag and pol genes show overall strong homologies indicating the close evolutionary relationship of the two retroviruses. However, a surface glycoprotein portion of the env gene s
Nakano S; Ando Y; Ichijo M; Moriyama I; Saito S; Sugamura K; Hinuma Y
Adult T-cell leukemia virus associated antigen (ATLA) was detected in peripheral mononuclear cells from 29 of 35 anti-ATLA-positive mothers, but was not detected in cells from any of the neonates. Cells from breast milk of all of 12 anti-ATLA-positive mothers and semen from one of three anti-ATLA positive men were ATL
Hino S; Kawamichi T; Funakoshi M; Kanamura M; Kitamura T; Miyamoto T
The incidence of anti-adult T-cell leukemia-associated antigens (ATLA) was surveyed in 134 patients under chronic hemodialysis in the Nagasaki area, as well as 4708 blood donors resident in the same area as controls: 23 patients (17%) and 201 donors (4.3%) were positive for anti-ATLA antibody. All seropositive patient
Acquired Immune Deficiency Syndrome (AIDS) occurs as a result of a defect in cell mediated immunity with a comparatively normal humoral immunity. Originally diagnosed in four distinct groups, AIDS is now recognized in six high-risk groups. Many theories of etiology exist; the most accepted etiologic agent is the Human
Z Gesamte Inn Med. 1984 Dec 15;39(24):605-11. Unique Identifier : AIDSLINE MED/85144448
Kolb E
It is reported on recent recognitions in the activation of cellular oncogens by carcinogens, by exchange (translocation) of genes within various chromosomes as well as by infection by the proviruses DNA of retroviruses. Cellular oncogens can be activated by a mutation already by the exchange of a base in a desoxyribon
We have highlighted the events leading to the discovery of the first human RNA tumor virus and then reviewed what is currently known about its biology. From this, it is clear that we have only begun to appreciate the biologic diversity, the geographic distribution, and the disease spectrum of this family of human T-ly
Persistent diarrhoea with mucus-production developed in a 37 year homosexual man, and an initial diagnosis of ulcerative colitis was made after barium enema examination and rectal biopsy. The patient later developed cutaneous lesions which proved to be Kaposi s sarcoma, and the bowel lesion was also subsequently shown
Hosp Community Psychiatry. 1985 Feb;36(2):173-6. Unique Identifier : AIDSLINE MED/85129020
Polan HJ; Hellerstein D; Amchin J
As more individuals whose lives are affected by acquired immune deficiency syndrome (AIDS) begin to need psychiatric hospitalization, psychiatric staffs must be prepared to handle the strong feelings aroused by the disease. The authors present case vignettes of four patients with AIDS-related problems admitted to a vo
Joshi VV; Oleske JM; Minnefor AB; Saad S; Klein KM; Singh R; Zabala M; Dadzie C; Simpser M; Rapkin RH
Lung tissue and tissue from the lymphoreticular system obtained at open biopsy and/or autopsy were studied in ten children with the acquired immunodeficiency syndrome (AIDS). One or both parents of nine of the children had AIDS or risk factors for AIDS. The remaining child had hemophilia. The following pulmonary lesio
Kiehn TE; Edwards FF; Brannon P; Tsang AY; Maio M; Gold JW; Whimbey E; Wong B; McClatchy JK; Armstrong D
The Mycobacterium avium complex, only rarely described as an invasive pathogen in humans, has recently been reported to frequently cause disseminated disease in patients with the acquired immune deficiency syndrome. Between February 1981 and February 1984 at Memorial Sloan-Kettering Cancer Center, 30 patients with acq
Intracranial opportunistic infections have been widely reported in patients with acquired immune deficiency syndrome (AIDS). We report an unusual presentation of Toxoplasma gondii infection in a patient with AIDS.
Autopsy findings in 41 patients with acquired immune deficiency syndrome (AIDS) were reviewed. Major pathologic findings in the heart were demonstrated in 10 cases, and metastatic Kaposi s sarcoma in either the epicardium or myocardium was revealed in 4 cases, including 1 with additional fibrinous pericarditis. Nonbac
Over an 18-year period we have diagnosed nodular lymphoid polyposis of the intestinal tract in 6 patients. The site of the polyposis, which was due to prominent lymphoid hyperplasia, was ileal (3), colonic (2), and rectal (1). The diagnosis was made following complications arising from the polyps, which included recur
Petito CK; Navia BA; Cho ES; Jordan BD; George DC; Price RW
Twenty of 89 consecutive patients with the acquired immunodeficiency syndrome (AIDS) in whom autopsies were performed over a 3 1/2-year period had a vacuolar myelopathy that was most severe in the lateral and posterior columns of the thoracic cord. Light and electron microscopy showed that vacuoles were surrounded by
The recent description of the acquired immune deficiency syndrome (AIDS) followed the observation of an increased incidence of unusual neoplasms and opportunistic infections in previously healthy homosexual men, intravenous drug abusers, Haitians, hemophiliacs, and certain infants. Active research efforts on this grou
Gaston A; Gherardi R; N'Guyen JP; Perroud AM; Wechsler J; Wallman J; Le Bras F; Marsault C
Authors report a case of fatal CNS toxoplasmosis in a young homosexual man suffering from Kaposi angio-sarcoma. This paper is principally concerned with CT scan and neuropathological correlations.
We reviewed the medical records and chest radiographs of 23 adult patients with culture-proved tuberculosis and verified acquired immune deficiency syndrome. Seventeen patients, including 8 with disseminated tuberculosis, had positive sputum or bronchial washing cultures for Mycobacterium tuberculosis. Their initial p
Ann Intern Med. 1985 Apr;102(4):471-5. Unique Identifier : AIDSLINE MED/85147113
Ognibene FP; Steis RG; Macher AM; Liotta L; Gelmann E; Pass HI; Lane HC; Fauci AS; Parrillo JE; Masur H; et al
Although an aggressive form of Kaposi s sarcoma often develops in patients with the acquired immunodeficiency syndrome, most patients die due to opportunistic infections rather than the direct effects of this tumor. Because Kaposi s sarcoma has caused pulmonary dysfunction in a number of our patients, we attempted to
Progressive multifocal leukoencephalopathy occurred in two homosexual men affected with acquired immune deficiency syndrome (AIDS). Both patients received HLA-matched platelet transfusions in an attempt to increase their immune status, but we were unsuccessful in altering their fatal clinical course.
Metastatic lesions of the CNS developed in two male patients with disseminated Kaposi s sarcoma. One patient was a homosexual, but the second patient had no apparent risk factors for disseminated Kaposi s sarcoma. These cases indicate that CNS involvement by tumor should be suspected in patients with Kaposi s sarcoma
Am J Hematol. 1985 Mar;18(3):319-23. Unique Identifier : AIDSLINE MED/85145809
Noah MS; Siddiqui MA
Autoimmune thrombocytopenic purpura associated with Kaposi s sarcoma in a 42-year-old male from the south of Saudi Arabia is reported. This association has not previously been reported in the medical literature. The occurrence of Ka
Bone marrow biopsies from 30 patients with acquired immunodeficiency syndrome (AIDS), diagnosed according to accepted clinical criteria, were studied in order to determine if characteristic histopathologic features were present. The biopsies were compared with 20 biopsy specimens submitted from patients with fever of
We studied the entire thymus gland by step-serial sections in four fatal cases of acquired immunodeficiency syndrome (AIDS) in children. The location, configuration, and blood vessels of the thymus gland were normal. The weight was reduced. There was severe depletion of both lymphocytes and Hassall s corpuscles. Becau
Proteins binding the third component of complement (C3) were isolated by affinity chromatography from surface-labeled solubilized membranes of human peripheral blood cells and cell lines. The isolated molecules were subjected to NaDodSO4/PAGE, and autoradiographs of these gels indicated that C3-binding proteins could
Am J Med. 1985 Mar;78(3):417-22. Unique Identifier : AIDSLINE MED/85145918
Lane HC; Masur H; Gelmann EP; Longo DL; Steis RG; Chused T; Whalen G; Edgar LC; Fauci AS
The present study was designed to determine whether there was a significant correlation between the clinical presentation of patients with AIDS or AIDS-related illnesses and the degree of their underlying immunologic abnormalities. In 17 patients who presented with opportunistic infections, the mean number of T4 lymph
Fourteen patients with acquired immunodeficiency syndrome (AIDS) or suspected AIDS underwent percutaneous needle lung aspiration (PNLA) for evaluation of 16 occurrences of acute pneumonitis. A 22-gauge spinal needle was passed 2 to 3 times in the area of greatest radiographic involvement under fluoroscopic guidance. T
Pepose JS; Kreiger AE; Tomiyasu U; Cancilla PA; Foos RY
An immunoperoxidase technique was utilized to identify herpes simplex type I viral antigens in the retina, optic nerve and brain of an adult with herpetic retinitis and encephalitis. Viral antigens were demonstrated in all layers of retina, retinal pigment epithelium and to a lesser extent, in choroid. Oligodendroglia
Ann Emerg Med. 1985 Mar;14(3):267-73. Unique Identifier : AIDSLINE MED/85146999
Skeen WF
Aids is a new public health disaster that is unlikely to be resolved quickly. It is manifested by a profound immune deficiency accompanied by the development of KS, PCP, and/or other opportunistic infections. A retrovirus, HTLV-III, is the probable cause of the immunosuppression, and it is transmitted in a manner simi
Raphael M; Pouletty P; Cavaille-Coll M; Rozenbaum W; Homond A; Nonnenmacher L; Delcourt A; Gluckman JC; Debre P
Lymph node biopsies of 12 patients at high risk for acquired immunodeficiency syndrome (AIDS) with generalized lymphadenopathy (AIDS-related complex [ARC]) and seven controls with conventional lymph node hyperplasia were examined by light microscopy and immunohistochemical staining of frozen tissue. The immunohistoche
We suspected a patient attending our Haemophilia Centre had developed Acquired Immunodeficiency Syndrome (AIDS) and therefore immunological evaluation was performed on 43 patients with haemophilia and von Willebrand s disease attending the Centre. The index patient died of Pneumocytis carinii pneumonia. Thirty-one pat
Antibody to Mycobacterium avium-Mycobacterium intracellulare antigen was measured by immunodiffusion, enzyme-linked immunosorbent assay (ELISA), and indirect immunofluorescence in sera from 30 patients with acquired immunodeficiency syndrome (AIDS), 10 patients with hairy cell leukemia, and 33 hospitalized and healthy
We investigated 18 sets of blood donors from 12 to 50 months after they donated blood to recipients who subsequently developed the acquired immunodeficiency syndrome (AIDS). Within each donor set, only one donor was suspected of having transmitted the disease (ie, member of an AIDS risk group). The other donors (n = 1
Embryonal cell carcinoma of the testis was seen in 2 homosexuals with peripheral lymphadenopathy of the head and neck, and abnormal cellular immunity measured by reduced T helper cells and increased T suppressor cells. One patient had no history of venereal disease but had taken marijuana, nitrites and methyl-dextroam
Schweiz Med Wochenschr. 1985 Jan 26;115(4):125-32. Unique Identifier : AIDSLINE MED/85142052
Joller-Jemelka HI; Vogt M; Joller PW
Since AIDS-specific laboratory tests are not yet commercially available, laboratory diagnoses of AIDS or of the AIDS-related complex (ARC) are based on surrogate markers. While single tests are of limited diagnostic value, test combinations are of greater help. However, these tests should be applied restrictively and
A survey of carriers of adult T-cell leukemia virus (ATLV) detected as anti-ATLV associated antigens was made in Taiwan . Among 2545 adults aged 30 years or more examined, seropositive donors amounted to 0.9% in the Han Chinese but n
Various retroviruses, including human T-cell lymphotropic virus (HTLV-I) and avian sarcoma virus (ASV), can prevent coincubated human peripheral lymphocytes from responding efficiently to phytohaemagglutinin. Addition of high concentrations of T-cell growth factor (TCGF) activity usually overcomes this inhibition. How
Int J Cancer. 1985 Mar 15;35(3):301-6. Unique Identifier : AIDSLINE MED/85129653
Aoki T; Miyakoshi H; Koide H; Yoshida T; Ishikawa H; Sugisaki Y; Mizukoshi M; Tamura K; Misawa H; Hamada C; et al
A large sample of carriers of human T-lymphotropic retrovirus type I (HTLV-I) in Niigata Prefecture was examined for the detection of natural antibodies to HTLV-I-related antigens in sera using both indirect immunofluorescence microscopy (IFM) and enzyme-linked immunosorbent assay (ELISA). The present findings are bas
Simian retroviruses closely related to human T-cell leukemia virus (HTLV) were isolated by establishing virus-producing lymphoid cell lines from 7 species of non-human primates. By co-cultivation with human umbilical cord-blood cells and/or in the presence of interleukin-2, lymphoid cell lines were successfully establ
Borysiewicz LK; Rodgers B; Morris S; Graham S; Sissons JG
We investigated the susceptibility of cells infected with human cytomegalovirus (HCMV) to lysis by human natural killer (NK) cells, examining in particular its relationship to sequential viral protein expression, interferon (IFN), and the nature of the effector cells. HCMV-infected
In this review of the acquired immunodeficiency syndrome (AIDS), the authors have evaluated a total of 352 homosexual patients with AIDS or generalized lymphadenopathy managed at the University of California, San Francisco (UCSF), between 1979 and 1984. Of an initial unselected group of 318 patients, 124 (39%) were ne
Seven cases of acquired immunodeficiency syndrome (AIDS) and AIDS-related complex (ARC) associated with human T-cell leukemia (lymphotropic) virus (HTLV)-III infection were documented in married males whose family members consented to medical evaluation. Five spouses also had evidence of HTLV-III infection documented
A human retrovirus was isolated from the peripheral blood of three American patients newly diagnosed with the acquired immunodeficiency syndrome (AIDS). In each case the major core viral protein (p25) was shown to be antigenically identical to that of the prototype lymphadenopathy-associated virus (LAV). Two of the vi
Antibodies to human T-cell lymphotropic virus type III (HTLV-III) were first detected in 1979 in serum samples from 30 known seropositive patients with hemophilia, over half of whom seroconverted in 1981-1982. Lymphadenopathy was present in 70% who were seropositive more than three years, compared with 10% who were se
Whang-Peng J; Bunn PA; Knutsen T; Kao-Shan CS; Broder S; Jaffe ES; Gelmann E; Blattner W; Lofters W; Young RC; et al
Cytogenetic studies were conducted on fresh and cultured cells from 11 patients with human T-cell leukemia virus-associated adult T-cell leukemia-lymphoma. Clones with abnormal karyotypes were detected in 9 of the 11 patients. Chromosome numbers were near-diploid in cells from all but 1 patient who also had a tetraplo
The Acquired Immunodeficiency Syndrome (AIDS) is a recently recognized syndrome caused by a newly described retrovirus, Human T-Cell Lymphotropic Virus-III(HTLV-III). A disease that selectively attacks the immune system, manifested by opportunistic infections and unusual neoplasms, AIDS has continued to be confined pr
We report the complete 8714-nucleotide sequence of the integrated bovine leukemia virus genome and deduce the following genomic organization: 5 LTR-gag-pol-env-pXBL-3 LTR, where LTR represents a long terminal repeat and pXBL represents a region containing unidentified open reading frames. This genomic structure is s
Berrebi A; Talmor M; Vorst EJ; Shtalrid M; Polliack A; Nir E
A 54-year-old asymptomatic male patient was followed for more than 7 y and presented a constant T cell lymphocytosis without skin involvement or bone marrow depression. No clinical or haematological aggravation was noted during this follow-up. Morphologically, the cells were large granular lymphocytes strongly positiv
Previous studies have shown that cyclosporin (CSA) inhibits lymphoproliferation to cytomegalovirus ( CMV )-infected, glutaraldehyde-fixed, and irradiated fibroblasts (CMVFFx) in vitro. Generation of cytotoxic cell activity is i
Science. 1985 Mar 1;227(4690):1036-8. Unique Identifier : AIDSLINE MED/85142107
Saxinger WC; Levine PH; Dean AG; de The G; Lange-Wantzin G; Moghissi J; Laurent F; Hoh M; Sarngadharan MG; Gallo RC
Fifty of 75 serum samples collected in the West Nile district of Uganda between August 1972 and July 1973 contained antibodies reactive with human T-cell leukemia (lymphotropic) virus type 3 (HTLV-III; mean titer, 601), while 12 of 75 samples were positive in a similar test for HTL
Science. 1985 Mar 8;227(4691):1227-8. Unique Identifier : AIDSLINE MED/85142128
Goh WC; Sodroski J; Rosen C; Essex M; Haseltine WA
Human T-cell leukemia virus type I (HTLV-I) is a retrovirus associated with adult T-cell leukemia and lymphoma. In addition to containing the gag, pol, and env genes of the chronic leukemia viruses, the genome of HTLV-I contains a long open reading frame (LOR) located between the 3 end of the envelope gene and the 3
Science. 1985 Mar 15;227(4692):1368-70. Unique Identifier : AIDSLINE MED/85142153
Engelman RW; Fulton RW; Good RA; Day NK
Supernatants from cultures of normal feline lymphocytes stimulated with Staphylococcus enterotoxin A showed antiviral activity, characterized as a gamma-like interferon. With the addition of inactivated feline leukemia virus, markedly less interferon was produced. The reduction in interferon production was not attribu
An earlier finding that lymphocytes from African patients with the acquired immune deficiency syndrome (AIDS) react with rabbit antiserum to purified antigens of bovine leukemia virus (BLV) prompted a study of the possible cross-reactions between a BLV-infected ovine cell line and human lymphocytes inoculated with a s
Chang NT; Chanda PK; Barone AD; McKinney S; Rhodes DP; Tam SH; Shearman CW; Huang J; Chang TW; Gallo RC; et al
Human T-cell lymphotropic virus type III (HTLV-III), the causative agent of the acquired immune deficiency syndrome (AIDS), was recently isolated and its genomic structure analyzed by DNA cloning methods. In the studies reported here a combined cloning and expression system was used to identify HTLV-III encoded peptid
Read EJ; Orenstein JM; Chorba TL; Schwartz AM; Simon GL; Lewis JH; Schulof RS
A 26-year-old male homosexual initially presented with Listeria monocytogenes sepsis and a small cell carcinoma of the rectum. His subsequent course included esophageal candidiasis, Pneumocystis carinii pneumonia, and severe T-lymphocyte abnormalities on immunologic testing, consistent with the acquired immunodeficien
Am J Gastroenterol. 1985 Mar;80(3):177-9. Unique Identifier : AIDSLINE MED/85145784
Salik JM; Kurtin P
Disseminated infections with cytomegalovirus have become an increasingly important cause of morbidity and mortality in patients with the acquired immune deficiency syndrome. Herein we describe a male homosexual with the acquired immune deficiency syndrome who became severely hypona
Am J Med. 1985 Mar;78(3):429-37. Unique Identifier : AIDSLINE MED/85145920
Stover DE; White DA; Romano PA; Gellene RA; Robeson WA
Over a four-year period, 130 patients with the acquired immune deficiency syndrome were studied to assess the incidence and spectrum of pulmonary disease associated with this illness. In 61 patients (47 percent), respiratory abnormalities were either present on admission or later developed. Multiple pathologic process
Immunoglobulin G antibodies to lymphadenopathy-associated virus have been detected in two groups of French hemophiliacs and in one group of Belgian hemophiliacs, whose mode of treatment differed. Seropositivity was more frequent (58.9%) in patients heavily transfused with blood products of French and foreign origin th
Lewis JH; Sundeen JT; Simon GL; Schulof RS; Wand GS; Gelfand RL; Miller H; Garrett CT; Jannotta FS; Orenstein JM
The association of disseminated magnesium silicate talc granulomatosis and acquired immunodeficiency syndrome is reported in a male homosexual who used intravenous drugs and who died of overwhelming cytomegalovirus ( CMV ) infe
Lancet. 1985 Mar 9;1(8428):537-40. Unique Identifier : AIDSLINE MED/85136596
Cooper DA; Gold J; Maclean P; Donovan B; Finlayson R; Barnes TG; Michelmore HM; Brooke P; Penny R
In the course of a prospective immunoepidemiological study of homosexual men in Sydney, seroconversion to the AIDS-associated retrovirus (ARV) was observed in 12 subjects. Review of the clinical files defined an acute infectious-mononucleosis-like illness in 11 subjects. The illness was of sudden onset, lasted from 3
Lancet. 1985 Mar 16;1(8429):602-4. Unique Identifier : AIDSLINE MED/85136644
Ho DD; Hartshorn KL; Rota TR; Andrews CA; Kaplan JC; Schooley RT; Hirsch MS
Recombinant human interferon alfa-A (rIFN alpha A) had a dose-related suppressive effect on human T lymphotropic virus type III (HTLV-III) replication in vitro in normal peripheral-blood mononuclear cells (PBMC). Both single-dose and multiple-dose regimens were inhibitory. Such inhibitory concentrations (4-1024 units/
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