Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.
LYMPHOTROPIC VIRUSES - EPSTEIN-BARR VIRUS (EBV) AND HUMAN T-CELL LEUKEMIA VIRUS (HTLV) - AS ETIOLOGIC AGENTS IN NON-HODGKIN'S LYMPHOMA (NHL)
UT MD Anderson Clin Conf Cancer; 27:137-52 1984. Unique Identifier : AIDSLINE ICDB/85608654 Purtilo DT; Harada S; Manolov G; Tatsumi E; Lipscomb H; Manolova Y; The Dept. of Pathology and Laboratory Medicine, Univ. of Nebraska; Medical Center, Omaha, Nebraska 68105
Abstract:
The subject of lymphotropic viruses as etiologic agents in non-Hodgkin's lymphoma (NHL) is reviewed under the following section headings and subheadings: Epstein-Barr virus (EBV)-induced lymphoproliferative diseases (primary immune deficiency and EBV-induced NHL; organ allograft recipients and EBV-induced lymphoproliferative disorders; acquired immune deficiency and NHL; human T-cell leukemia virus [HTLV], and induction of adult T-cell leukemia; HTLV and adult T-cell lymphoma; HTLV as possible etiologic agent of acquired immune deficiency syndrome [AIDS]), mechanisms of induction of virally induced immunodeficiency and neoplasia (thymic epithelial destruction and progressive immune deficiency; conversion from polyclonality to monoclonality by rearrangement of genes and chromosomes; molecular events in B-cell lymphomagenesis), and summary and comparison of Epstein-Barr and HTLVs. Differences between EBV and HTLVs with respect to age at infection, distribution, detection, viral type, target cells, paraneoplastic syndrome, karyotype, predominant location of neoplasms, NHL, clonality, immune deficiency, chemotherapy, antiviral therapy, and diseases caused are presented in a table. It appears that EBV is more important in the induction of lymphoma and other diseases overall than is HTLV. Although HTLV-I has been implicated etiologically with AIDS, the authors summarize considerable evidence to the contrary; more likely EBV, cytomegalovirus, and other agents that infect simultaneously induce the AIDS. HTLV-II is a new candidate for causing AIDS. It is considered to be likely that ubiquitous viruses common in a subset of male homosexuals overwhelm the immune system.
Keywords: Acquired Immunodeficiency Syndrome/IMMUNOLOGY/MICROBIOLOGY Animal Cell Transformation, Neoplastic/IMMUNOLOGY Herpesvirus 4, Human/PATHOGENICITY Human HTLV-BLV Viruses/PATHOGENICITY Immunity, Cellular Immunologic Deficiency Syndromes/IMMUNOLOGY Lymphoma/GENETICS/IMMUNOLOGY/MICROBIOLOGY Pedigree Retroviridae Infections/IMMUNOLOGY/MICROBIOLOGY Risk Tumor Virus Infections/IMMUNOLOGY/MICROBIOLOGY MEETING PAPER
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Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.
