Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.
ACQUIRED IMMUNODEFICIENCY SYNDROME IN THE DEVELOPMENT OF LYMPHOMA
UT MD Anderson Clin Conf Cancer; 27:277-98 1984. Unique Identifier : AIDSLINE ICDB/85608666 Koziner B; Urmacher C; Chaganti RS; Clarkson BD; Dept. of Medicine, Memorial Sloan-Kettering Cancer Center, New; York, NY 10021
Abstract:
An increased incidence of secondary neoplasms, including oral and rectal carcinomas and Burkitt's-like lymphoma, have recently been noted in immunodeficient homosexual men; also, the development of malignant non-Hodgkin's lymphoma (NHL) has been observed, not only in acute immunodeficiency syndrome (AIDS) patients but also in homosexual men who are without the syndrome but who have laboratory markers of immunodeficiency and epidemiologic backgrounds similar to those of AIDS patients. Three cases of homosexual men with Burkitt's lymphoma, one with diffuse histiocytic lymphoma, one with lymphoplasmacytoid lymphoma, one with malignant plasmacytoma, one with acute lymphoblastic leukemia, and three with malignant lymphomas of the brain are presented. The finding of lymphoma in homosexual men and AIDS patients is discussed under the following section headings: preneoplastic potential of lymphadenopathy in homosexual men and AIDS patients, pathogenetic role of cytomegalovirus in the development of Kaposi sarcoma and malignant lymphomas, pathogenetic mechanisms for lymphoma development, role of Epstein-Barr virus in lymphoma development, Burkitt's lymphoma as a model for lymphoma development, development of brain lymphomas: its relationship with Epstein-Barr virus (EBV), and oncogenicity of retroviruses. Pathogenetic mechanisms for neoplastic development in patients with AIDS or AIDS-related complex appear to be similar to the ones previously proposed in patients with congenital and drug-induced immunodeficiencies, including the probable activation of endogenous viruses or infection with exogenous oncogenic viruses. Although a variety of B-cell neoplasias have been observed, large cell lymphomas of the brain and systemic Burkitt's-like lymphomas are more frequent; serologic and cytogenetic evidence suggests involvement of EBV in the pathogenesis of these neoplasms.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS/IMMUNOLOGY Adult Animal Antibodies, Monoclonal/ANALYSIS B-Lymphocytes/IMMUNOLOGY Brain Neoplasms/IMMUNOLOGY Burkitt's Lymphoma/ETIOLOGY Case Report Herpesvirus 4, Human Homosexuality Human Leukemia, Lymphocytic/IMMUNOLOGY Leukocyte Count Lymphoma/*ETIOLOGY/IMMUNOLOGY Lymphoma, Large-Cell/ETIOLOGY Plasmacytoma/ETIOLOGY T-Lymphocytes/IMMUNOLOGY Tumor Virus Infections/ETIOLOGY GOVERNMENT REPORT
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Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.
