Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.
B-CELL SMALL NONCLEAVED UNDIFFERENTIATED LYMPHOMA IN ADULTS
UT MD Anderson Clin Conf Cancer; 27:321-6 1984. Unique Identifier : AIDSLINE ICDB/85608669 Levine AM; Pavlova Z; Parker JW; Paganini-Hill A; Powars DR; Lukes RJ; Feinstein DI; Dept. of Medicine, Univ. of Southern California Sch. of Medicine,; Los Angeles, CA 90033
Abstract:
Burkitt's lymphoma, described as a tumor oriented about the jaw in children living in Uganda, is endemic not only in Uganda but also throughout the malaria belt of equatorial Africa. In these regions, an association between the Epstein-Barr virus (EBV) and the development of the lymphoma was found. A morphologically identical tumor has been described in the United States and other endemic areas of the world, but there is no relation between this tumor and EBV; further, the majority of these tumors occur in the abdomen. Aside from the classic Burkitt's tumor, another morphologic variant has been described in nonendemic regions, termed non-Burkitt's lymphoma. With an appreciation of the fact that Burkitt's lymphoma is of B cell type of follicular center cell (FCC) derivation, Lukes and Collins chose to classify it under the designation of small noncleaved FCC lymphoma; within this group, the subtypes of Burkitt's type and non-Burkitt's variant are described. In an attempt to define the clinicopathologic features of the two subtypes in the United States, the authors studied 25 patients of the former type and 17 of the latter. The current study demonstrated that the morphologic separation between the variants is fairly easy to make in the majority of cases. The B-cell nature of the tumor was confirmed by the demonstration of surface or intracytoplasmic immunoglobulin in most cells of each variant. The Burkitt's patients tended to present at an earlier age. The Burkitt's tumor presented initially in the abdomen and GI tract, with relative sparing of the bone marrow, which was in contradistinction to the non-Burkitt's cases. Short survival was common to both types. Both types were found in homosexual males with immunologic abnormalities similar to those described in acquired immunodeficiency syndrome.
Keywords: Adult Antineoplastic Agents, Combined/THERAPEUTIC USE B-Lymphocytes/*ULTRASTRUCTURE Biopsy Burkitt's Lymphoma/PATHOLOGY Gastrointestinal Neoplasms/PATHOLOGY Human Lymph Nodes/PATHOLOGY Lymphoma/DRUG THERAPY/*PATHOLOGY Neoplasm Staging Prognosis GOVERNMENT REPORT
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Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.
