The liver in the acquired immunodeficiency syndrome: a clinical and histologic study. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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The liver in the acquired immunodeficiency syndrome: a clinical and histologic study.

Hepatology. 1985 Mar-Apr;5(2):293-8. Unique Identifier : AIDSLINE MED/85155903
Lebovics E; Thung SN; Schaffner F; Radensky PW

Abstract: We reviewed the clinical data and hepatic histologic findings of 25 patients with the acquired immunodeficiency syndrome who underwent 29 liver biopsies. Our experience indicates that the only hepatic feature characteristic of acquired immunodeficiency syndrome is serologic evidence of exposure to the hepatitis B virus. The most common histologic finding was macrovesicular steatosis. Granulomas appeared in seven patients and were due to mycobacterial disease (3 patients), histoplasmosis (1 patient), adverse reaction to sulfonamide (2 patients) and unknown causes (1 patient). The clinical indication for liver biopsy was not significantly different in the patients without or with granulomas or with granulomas secondary to mycobacteria or fungi. Mycobacteria were cultured from all histologically positive specimens and one histologically negative specimen. Liver biopsy should be performed in any patient with acquired immunodeficiency syndrome who has unexplained fever, hepatomegaly or abnormal results of serum biochemical liver tests, and all specimens should be stained and cultured for mycobacteria and fungi.
Keywords: Acquired Immunodeficiency Syndrome/BLOOD/COMPLICATIONS/*PATHOLOGY/ PHYSIOPATHOLOGY Adolescence Adult Biopsy Child Child, Preschool Female Hepatomegaly/ETIOLOGY/PATHOLOGY Human Liver/*PATHOLOGY Liver Diseases/COMPLICATIONS/*PATHOLOGY/PHYSIOPATHOLOGY Liver Function Tests Male Middle Age JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/blood/complications/KWDpathology/physiopathologyadolescenceadultbiopsychildchild,preschoolfemalehepatomegaly/etiology/pathologyhumanliver/KWDpathologyliverdiseases/complications/KWDpathology/physiopathologyliverfunctiontestsmalemiddleagejournalarticle
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M8570137

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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