Myelopathy following intrathecal chemotherapy in a patient with extensive Burkitt's lymphoma and altered immune status. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Myelopathy following intrathecal chemotherapy in a patient with extensive Burkitt's lymphoma and altered immune status.

Am J Med. 1985 Apr;78(4):697-702. Unique Identifier : AIDSLINE MED/85171999
Bates S; McKeever P; Masur H; Levens D; Macher A; Armstrong G; Magrath IT

Abstract: A 30-year-old homosexual man presented with widespread Burkitt's lymphoma. On the basis of immunologic and viral studies, he was suspected of having the acquired immune deficiency syndrome. Following chemotherapy that included intrathecal cytosine arabinoside and methotrexate, brain stem edema, paraplegia, and an elevated cerebrospinal fluid level of myelin basic protein developed. Autopsy revealed vacuolar demyelination of spinal cord, brain stem, and cerebellum. The pathologic findings were similar to those reported to occur in myelopathy associated with intrathecal chemotherapy, but far more extensive. The contribution of the suspected acquired immune deficiency syndrome is unknown.
Keywords: Acquired Immunodeficiency Syndrome/PATHOLOGY Adult Antineoplastic Agents, Combined/ADMINISTRATION & DOSAGE/*ADVERSE EFFECTS Brain Diseases/*PATHOLOGY Brain Stem/PATHOLOGY Burkitt's Lymphoma/*DRUG THERAPY/IMMUNOLOGY/PATHOLOGY Case Report Cerebellum/PATHOLOGY Demyelinating Diseases/CHEMICALLY INDUCED/*PATHOLOGY Encephalitogenic Basic Proteins/ANALYSIS Homosexuality Human Injections, Spinal/ADVERSE EFFECTS Male Spinal Cord Diseases/*PATHOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/pathologyadultantineoplasticagents,combined/administration&dosage/KWDadverseeffectsbraindiseases/KWDpathologybrainstem/pathologyburkitt'slymphoma/KWDdrugtherapy/immunology/pathologycasereportcerebellum/pathologydemyelinatingdiseases/chemicallyinduced/KWDpathologyencephalitogenicbasicproteins/analysishomosexualityhumaninjections,spinal/adverseeffectsmalespinalcorddiseases/KWDpathologyjournalarticle
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Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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