The acquired immunodeficiency syndrome: an ultrastructural study. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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The acquired immunodeficiency syndrome: an ultrastructural study.

Hum Pathol. 1985 Apr;16(4):377-86. Unique Identifier : AIDSLINE MED/85156019
Sidhu GS; Stahl RE; el-Sadr W; Cassai ND; Forrester EM; Zolla-Pazner S

Abstract: Blood and a variety of tissues from 97 patients with the acquired immunodeficiency syndrome (AIDS) and 25 with the AIDS prodrome were studied ultrastructurally. Tubuloreticular structures (TRS) were found in 85 per cent of the patients with AIDS and in 92 per cent of those with the prodrome. Test tube and ring-shaped forms (TRF), found in 41 per cent of the patients with AIDS and in 8 per cent of those with the prodrome, increased with disease progression. Among the patients with AIDS, as the number of sites examined per case increased, the incidence of TRS and TRF tended to approach 100 per cent, suggesting that they are present in all patients with AIDS. Other changes seen frequently were immunologic capping of blood lymphocytes, intramitochondrial iron in blood reticulocytes and marrow normoblasts, megakaryocytic immaturity and platelet phagocytosis, collections of membranous rings in hepatocytic cytoplasm, suggestive of non-A, non-B hepatitis, and proliferations and engorgement of hepatic Ito cells with lipid. The data suggest that TRS and TRF can be used as diagnostic and prognostic markers.
Keywords: Acquired Immunodeficiency Syndrome/IMMUNOLOGY/*PATHOLOGY Autoimmune Diseases/PATHOLOGY Bone Marrow/ULTRASTRUCTURE Female Homosexuality Human Liver/ULTRASTRUCTURE Lymph Nodes/ULTRASTRUCTURE Male Megakaryocytes/ULTRASTRUCTURE Microscopy, Electron Monocytes/ULTRASTRUCTURE Phagocytosis Support, Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S. T-Lymphocytes/*ULTRASTRUCTURE Thrombocytopenia/PATHOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/immunology/
850730
M8570110

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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