Immunologic and immunogenetic features of primary Kaposi's sarcoma. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Immunologic and immunogenetic features of primary Kaposi's sarcoma.

Cancer. 1985 May 1;55(9):1899-901. Unique Identifier : AIDSLINE MED/85151630
Marinig C; Fiorini G; Boneschi V; Melotti E; Brambilla L

Abstract: In order to establish if immunologic alterations seen in acquired immunodeficiency syndrome (AIDS)-associated Kaposi's sarcoma are also present in the primary form of this malignancy, peripheral blood T-lymphocyte characterization and HLA A, B, C, and DR phenotyping have been carried out in 18 patients with the primary form of the disease. HLA antigen distribution was not significantly different from that of the normal population and, in particular, DR5 was only marginally increased. The T4/T8 ratio was significantly higher in the patients than in the control group, and this was due to a marked decrease in suppressor cells. The possible pathogenetic relevance of these findings is discussed.
Keywords: Aged Antibodies, Monoclonal Female Histocompatibility Antigens Class II/ANALYSIS Human HLA Antigens/ANALYSIS Male Sarcoma, Kaposi's/GENETICS/*IMMUNOLOGY T-Lymphocytes/IMMUNOLOGY T-Lymphocytes, Suppressor-Effector/IMMUNOLOGY JOURNAL ARTICLE

KWDagedantibodies,monoclonalfemalehistocompatibilityantigensclassii/analysishumanhlaantigens/analysismalesarcoma,kaposi's/genetics/KWDimmunologyt-lymphocytes/immunologyt-lymphocytes,suppressor-effector/immunologyjournalarticle
850730
M8570076

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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