Clinical features of Pneumocystis pneumonia in the acquired immune deficiency syndrome. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Clinical features of Pneumocystis pneumonia in the acquired immune deficiency syndrome.

Am Rev Respir Dis. 1984 Oct;130(4):689-94. Unique Identifier : AIDSLINE MED/85020905
Engelberg LA; Lerner CW; Tapper ML

Abstract: The courses of 19 patients with Pneumocystis carinii pneumonia complicating the acquired immune deficiency syndrome (AIDS) were reviewed. Compared with previous reviews of Pneumocystis pneumonia in patients without AIDS, Pneumocystis pneumonia in patients with AIDS often has a more prolonged clinical prodrome, with pulmonary symptoms occurring for an average of 3 wk prior to presentation, and often has a slower response to therapy, with radiographic and blood gas improvement occurring an average of 13 and 6 days, respectively, after initiation of therapy. No patient diagnosed during life died as a result of Pneumocystis infection; however, 5 required repeat courses of therapy, and 7 required repeat lung biopsies during the course of treatment. Serious side effects of trimethoprim-sulfamethoxazole therapy included fever, rash, and leukopenia, and occurred in 12 patients. Aggressive diagnostic and therapeutic measures combined with prolonged therapy are required for a satisfactory outcome in patients with AIDS and Pneumocystis pneumonia.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adult Drug Combinations/ADVERSE EFFECTS/THERAPEUTIC USE Female Human Male Middle Age Pentamidine/ADVERSE EFFECTS/THERAPEUTIC USE Pneumonia, Pneumocystis carinii/*COMPLICATIONS/DRUG THERAPY/ PHYSIOPATHOLOGY Retrospective Studies Sulfamethoxazole/ADVERSE EFFECTS/THERAPEUTIC USE Support, Non-U.S. Gov't Trimethoprim/ADVERSE EFFECTS/THERAPEUTIC USE JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDcomplicationsadultdrugcombinations/adverseeffects/therapeuticusefemalehumanmalemiddleagepentamidine/adverseeffects/therapeuticusepneumonia,pneumocystiscarinii/KWDcomplications/drugtherapy/physiopathologyretrospectivestudiessulfamethoxazole/adverseeffects/therapeuticusesupport,non-uKWDsKWDgov'ttrimethoprim/adverseeffects/therapeuticusejournalarticle
850130
M8510056

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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