[Acquired immunodeficiency syndrome and related syndromes. Critical analysis of biological tests of cell-mediated immunity] NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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[Acquired immunodeficiency syndrome and related syndromes. Critical analysis of biological tests of cell-mediated immunity]

Presse Med. 1984 Sep 22;13(32):1937-41. Unique Identifier : AIDSLINE MED/85014736
Gluckman JC; Cavaille-Coll M; Klatzmann D; Messiah A; Rozenbaum W; Lachiver D; Kernbaum S; Debre P; Brisson E; Chapuis F

Abstract: In order to assess the actual value of the in vitro tests of cellular immunity performed to provide diagnostic evidence for acquired immune deficiency syndrome (AIDS) or related syndromes, we have evaluated T-lymphocyte subsets and in vitro proliferative responses. The respective profiles of 44 symptom-free homosexual men, 30 patients with AIDS and 42 patients with lymphadenopathy were compared with each other and with profiles of blood bank volunteers, using stepwise discriminant analysis. At first investigation, control homosexuals, AIDS patients and lymphadenopathy patients displayed varying degrees of the same type of immunological abnormalities. The percentage of OKT4+ cells was the most discriminant variable between blood donors and control homosexuals, AIDS or lymphadenopathy patients. The latter differed from homosexuals by a higher percent of OKT8+ cells and from AIDS patients by a lesser reduction in T-lymphocyte counts. OKT4+ cell counts differentiated AIDS patients from control homosexuals. However, none of these major discriminant variables could classify correctly more than 70% of subjects in the homosexual and in the two patient groups. Thus, a single investigation of T-lymphocyte immune parameters does not provide substantial diagnostic and prognostic evidence.
Keywords: Acquired Immunodeficiency Syndrome/*DIAGNOSIS/IMMUNOLOGY English Abstract Female Homosexuality Human Immunity, Cellular Immunologic Deficiency Syndromes/*DIAGNOSIS/IMMUNOLOGY *Immunologic Techniques Leukocyte Count/METHODS Lymphocyte Transformation Lymphocytes Male Risk Support, Non-U.S. Gov't JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDdiagnosis/immunologyenglishabstractfemalehomosexualityhumanimmunity,cellularimmunologicdeficiencysyndromes/KWDdiagnosis/immunologyKWDimmunologictechniquesleukocytecount/methodslymphocytetransformationlymphocytesmalerisksupport,non-uKWDsKWDgov'tjournalarticle
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M8510039

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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