Establishment of T and B cell lines from patients with mycosis fungoides. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Establishment of T and B cell lines from patients with mycosis fungoides.

Br J Dermatol. 1984 Sep;111(3):303-8. Unique Identifier : AIDSLINE MED/85000312
Kaltoft K; Thestrup-Pedersen K; Jensen JR; Bisballe S; Zachariae H

Abstract: Eighteen patients with mycosis fungoides were studied in order to establish cell lines that might be associated with the human T cell leukaemia-lymphoma virus (HTLV). Three T cell lines were established, two from affected skin and one from a lymph node showing dermatopathic lymphadenopathy. The T cells expressed OKT3 and OKT4 antigens. They temporarily expressed an HTLV p19-like antigen in up to 5% of the cells during culture. None of our patients had lymphocytosis or abnormal lymphocytes, except one patient with Sezary's syndrome. We could not establish T cell lines from peripheral blood, but five B lymphoblastoid cell lines were obtained, all positive for the Epstein-Barr virus nuclear antigen. Our finding that T cell lines can be established from skin biopsies and lymph nodes of patients with mycosis fungoides, but not from the blood, supports the concept of a malignant T lymphocyte primarily localized in the skin. The temporary expression of HTLV p19 antigen may indicate the presence of retrovirus, but further studies are needed.
Keywords: Adult Aged Antigens, Viral/ANALYSIS *B-Lymphocytes/IMMUNOLOGY *Cell Line Cytological Techniques Female Fluorescent Antibody Technique Human HTLV-BLV Viruses/IMMUNOLOGY Lymph Nodes/PATHOLOGY Male Middle Age Mycosis Fungoides/IMMUNOLOGY/*PATHOLOGY Skin/PATHOLOGY Skin Neoplasms/IMMUNOLOGY/*PATHOLOGY Support, Non-U.S. Gov't *T-Lymphocytes/IMMUNOLOGY JOURNAL ARTICLE

KWDadultagedantigens,viral/analysisKWDb-lymphocytes/immunologyKWDcelllinecytologicaltechniquesfemalefluorescentantibodytechniquehumanhtlv-blvviruses/immunologylymphnodes/pathologymalemiddleagemycosisfungoides/immunology/KWDpathologyskin/pathologyskinneoplasms/immunology/KWDpathologysupport,non-uKWDsKWDgov'tKWDt-lymphocytes/immunologyjournalarticle
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Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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