Effect of tumor promoters on human T cell leukemia/lymphoma virus (HTLV)-structural protein induction in adult T-cell leukemia cells. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Effect of tumor promoters on human T cell leukemia/lymphoma virus (HTLV)-structural protein induction in adult T-cell leukemia cells.

Cancer Lett. 1984 Sep;24(2):129-39. Unique Identifier : AIDSLINE MED/85001842
Nakao Y; Matsuda S; Matsui T; Nakagawa T; Fujita T; Uchiyama T; Maeda S; Okamoto Y; Masaoka T; Ito Y

Abstract: We assayed the capacity of tumor promoters to induce human T-cell leukemia/lymphoma virus (HTLV) structural proteins p19 and p24 from the HTLV genome-carrying adult T-cell leukemia (ATL) cell lines, MT-1 and KH-2Lo, and fresh ATL cells. Among the tested substances, 12-O-tetradecanoyl phorbol-13-acetate (TPA), 12-hexadecanoyl-phorbol-13-acetate (HPA) and teleocidin induced HTLV structural protein p19 and p24. This suggests that certain environmental substances, especially those known to be tumor promoters, may activate the HTLV-gene in ATL cells.
Keywords: Adult Antigens, Surface/ANALYSIS Antigens, Viral/ANALYSIS Carcinogens/*TOXICITY Cell Line Human HTLV-BLV Viruses/DRUG EFFECTS/*GENETICS Leukemia Structure-Activity Relationship Support, Non-U.S. Gov't T-Lymphocytes Viral Proteins/*BIOSYNTHESIS JOURNAL ARTICLE

KWDadultantigens,surface/analysisantigens,viral/analysiscarcinogens/KWDtoxicitycelllinehumanhtlv-blvviruses/drugeffects/KWDgeneticsleukemiastructure-activityrelationshipsupport,non-uKWDsKWDgov'tt-lymphocytesviralproteins/KWDbiosynthesisjournalarticle
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M8510033

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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