A case of Japanese Burkitt's lymphoma associated with EB virus. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


A case of Japanese Burkitt's lymphoma associated with EB virus.

Jpn J Clin Oncol. 1984 Sep;14(3):445-50. Unique Identifier : AIDSLINE MED/85010148
Shikano T; Ueno N; Matsumoto T; Ohkawa M; Tono-Oka T; Okano M; Yano S; Osato T

Abstract: A 6-year-old girl was admitted for cervical lymphadenopathy. She was diagnosed histologically as having Burkitt's lymphoma with partial involvement of follicles. Immunological study of a biopsy specimen demonstrated that many cells were surface immunoglobulin (lambda light chain)-positive, and chromosomal analysis revealed a translocation of (8;14) (q24;q32) in all blastic cells. Her serum antibody titers to Epstein-Barr virus (EBV) capsid antigen and to early antigen were 1:320 and 1:160, respectively, and most of the cells from the lymphoma biopsy specimen were EBV-associated nuclear antigen (EBNA)-positive. In addition, EBV DNA/DNA reassociation kinetic analysis showed 22 EBV genome equivalents per cell. Complete remission was obtained by CHOP therapy (consisting of cyclophosphamide, adriamycin, vincristine, and prednisolone) combined with cervical irradiation. She is in complete remission now (17 months after the onset).
Keywords: Antigens, Viral/ANALYSIS Burkitt's Lymphoma/IMMUNOLOGY/*MICROBIOLOGY/PATHOLOGY Capsid/ANALYSIS Case Report Child Chromosomes, Human, 13-15 Chromosomes, Human, 6-12 DNA, Viral/ANALYSIS Female Herpesvirus 4, Human/GENETICS/*ISOLATION & PURIF Human Translocation (Genetics) JOURNAL ARTICLE

KWDantigens,viral/analysisburkitt'slymphoma/immunology/KWDmicrobiology/pathologycapsid/analysiscasereportchildchromosomes,human,13-15chromosomes,human,6-12dna,viral/analysisfemaleherpesvirus4,human/genetics/KWDisolation&purifhumantranslocation(genetics)journalarticle
850130
M8510027

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1985. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1985. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .