Karyotypic differences between primary cultures and cell lines from tumors with the human T-cell leukemia virus. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Karyotypic differences between primary cultures and cell lines from tumors with the human T-cell leukemia virus.

J Natl Cancer Inst. 1984 Oct;73(4):849-52. Unique Identifier : AIDSLINE MED/85010458
Nowell PC; Finan JB; Clark JW; Sarin PS; Gallo RC

Abstract: Chromosome abnormalities were studied in primary cultures and in established T-cell lines from patients with human T-cell leukemia virus (HTLV)-positive leukemia or lymphoma. The present findings, and data from other laboratories, indicated that primary cultures of the HTLV-positive neoplastic cells nearly always showed a chromosomally abnormal clone, whereas most established cell lines had an apparently normal karyotype. These differences included circumstances in which the same blood specimen was used for both types of culture or in which separate specimens were obtained within a short time span. These observations indicated that many cell lines from HTLV-positive leukemia or lymphoma may be derived from nonneoplastic T-cells that were transformed in vitro by the leukemia virus; human T-cells newly infected with HTLV were suggested to have an in vitro growth advantage over the HTLV-infected tumor cells.
Keywords: Cell Line Cells, Cultured Human HTLV-BLV Viruses/*ISOLATION & PURIF Karyotyping Leukemia/GENETICS/*MICROBIOLOGY Lymphoma/GENETICS/*MICROBIOLOGY Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

KWDcelllinecells,culturedhumanhtlv-blvviruses/KWDisolation&purifkaryotypingleukemia/genetics/KWDmicrobiologylymphoma/genetics/KWDmicrobiologysupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
850130
M8510025

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1985. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1985. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .