Molecular cloning and expression of cDNAs for the human interleukin-2 receptor. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Molecular cloning and expression of cDNAs for the human interleukin-2 receptor.

Nature. 1984 Oct 18-24;311(5987):626-31. Unique Identifier : AIDSLINE GENBANK/X01402
Leonard WJ; Depper JM; Crabtree GR; Rudikoff S; Pumphrey J; Robb RJ; Kronke M; Svetlik PB; Peffer NJ; Waldmann TA; et al

Abstract: We have purified the human T-cell growth factor (interleukin-2) receptor and have cloned, sequenced and expressed cDNAs corresponding to this receptor. We identify one gene, but two interleukin-2 receptor mRNAs which differ in their polyadenylation signals. We have isolated an additional cDNA that may correspond to an alternatively spliced mRNA that lacks a 216 base segment and appears to encode an altered membrane protein which cannot bind interleukin-2.
Keywords: Amino Acid Sequence Base Sequence *Cloning, Molecular DNA/*METABOLISM *Genes, Structural Genes, Viral Human HTLV-BLV Viruses/GENETICS Nucleic Acid Hybridization Receptors, Antigen, T-Cell/*GENETICS Receptors, Immunologic/*GENETICS/ISOLATION & PURIF RNA, Messenger/GENETICS Translation, Genetic JOURNAL ARTICLE

KWDaminoacidsequencebasesequenceKWDcloning,moleculardna/KWDmetabolismKWDgenes,structuralgenes,viralhumanhtlv-blvviruses/geneticsnucleicacidhybridizationreceptors,antigen,t-cell/KWDgeneticsreceptors,immunologic/KWDgenetics/isolation&purifrna,messenger/geneticstranslation,geneticjournalarticle
850130
M8510019

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1985. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1985. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .